English Journal

Nitric oxide as a target for the hypotensive and vasorelaxing effects induced by (Z)-ethyl 12-nitrooxy-octadec-9-enoate in rats.

Machado NT1, Maciel PM1, Alustau MC1, Queiroz TM1, Furtado FF1, Assis VL1, Veras RC1, Araújo IG1, Athayde-Filho PF2, Medeiros IA3.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2014 Oct 1;62:317-25. doi: 10.1016/j.ejps.2014.06.012. Epub 2014 Jun 22.
The cardiovascular effects induced by a new organic nitrate were investigated in rats. The (Z)-ethyl 12-nitrooxy-octadec-9-enoate (NCOE) was synthesized from ricinoleic acid, the major compound of the castor oil. NCOE induced significant and dose-dependent hypotension and bradycardia in normotensive
PMID 24964291

Delphinidin inhibits VEGF induced-mitochondrial biogenesis and Akt activation in endothelial cells.

Duluc L1, Jacques C2, Soleti R3, Andriantsitohaina R4, Simard G5.
The international journal of biochemistry & cell biology.Int J Biochem Cell Biol.2014 Aug;53:9-14. doi: 10.1016/j.biocel.2014.03.030. Epub 2014 Apr 30.
Delphinidin, an anthocyanin present in red wine, has been reported to exert vasculoprotective properties on endothelial cells, including vasorelaxing and anti-apoptotic effects. Moreover, delphinidin treatment in a rat model of post-ischemic neovascularization has been described to exert anti-angiog
PMID 24792670

Vascular L-Type Ca(2+) Channel Blocking Activity of Sulfur-Containing Indole Alkaloids from Glycosmis petelotii.

Cuong NM1, Khanh PN, Huyen PT, Duc HV, Huong TT, Ha VT, Durante M, Sgaragli G, Fusi F.
Journal of natural products.J Nat Prod.2014 Jul 25;77(7):1586-93. doi: 10.1021/np500076v. Epub 2014 Jun 20.
In the search for novel natural compounds endowed with potential antihypertensive activity, a new sulfur-containing indole alkaloid, N-demethylglypetelotine (2), and its known analogue glypetelotine (1), were isolated from the leaves of Glycosmis petelotii. Their structures were established on the b
PMID 24949913

Japanese Journal

Vasorelaxing and anti-hypertensive effect of dipeptide Arg-(aromatic amino acid)

KAGEBAYASHI Tomomi,KONTANI Noriyasu,YAMADA Yuko,OHINATA Kousaku
Peptide science : proceedings of the ... Japanese Peptide Symposium 2010, 87, 2011-03-01
NAID 10028237359

Fraxinellone Inhibits Lipopolysaccharide-Induced Inducible Nitric Oxide Synthase and Cyclooxygenase-2 Expression by Negatively Regulating Nuclear Factor-kappa B in RAW 264.7 Macrophages Cells

Kim Jong-Hwan,Park Young-Mi,Shin Ji-Sun,Park Seung Jae,Choi Jung-Hye,Jung Hyun-Ju,Park Hee-Juhn,Lee Kyung-Tae
Biological and Pharmaceutical Bulletin 32(6), 1062-1068, 2009
… Fraxinellone has been reported to possess neuroprotective and vasorelaxing activities, but the effects and the mechanism of fraxinellone in inflammation have not been fully characterized. …
NAID 130000117188