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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/12 15:34:35」(JST)
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Urofollitropin
| Clinical data |
| Trade names |
Bravelle, Fertinex |
| AHFS/Drugs.com |
Micromedex Detailed Consumer Information |
Pregnancy
category |
|
| Legal status |
|
Routes of
administration |
Subcutaneous, intramuscular |
| Identifiers |
| CAS Number |
146479-72-3 Y |
| ATC code |
G03GA04 |
| PubChem |
CID: 62819 |
| IUPHAR/BPS |
1157 |
| DrugBank |
DB00094 N |
| UNII |
W9BB98U6HP N |
| KEGG |
D06400 Y |
| ChEMBL |
CHEMBL1201520 N |
| Chemical data |
| Formula |
C975H1513N267O304S26 |
| Molecular mass |
22672.9 g/mol |
| NY (what is this?) (verify) |
Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified[1] to remove various proteins and other substances. FSH is important in the development of follicles (eggs) produced by the ovaries. Given by subcutaneous injection, it is used in combination with human chorionic gonadotropin (hCG) to assist in ovulation and fertility.[2] It is also used with in vitro fertilization methods. The dosage is adjusted to each individual's response.[2]
The most common side effects are abdominal or pelvic pain, bloating, as well as redness, pain or swelling at the injection site. Follitropin is possibly associated with increased risk of endometrial carcinoma. It is not for use during pregnancy, as there is evidence for birth defects under follitropin treatment.[2]
References
- ^ Van Wely, M.; Yding Andersen, C.; Bayram, N.; Van Der Veen, F. (2005). "Urofollitropin and ovulation induction". Treatments in endocrinology 4 (3): 155–165. PMID 15898821.
- ^ a b c Drugs.com: Urofollitropin (Intramuscular route, Subcutaneous route, Injection route)
External links
- Bravelle, by Ferring Pharmaceuticals, Switzerland
- Fostimon by Institut Biochemique SA, Switzerland
|
Gonadotropins and GnRH (G03G)
|
|
Gonadotropin
preparations |
| Gonadotropins |
- Follicle-stimulating hormone
- Human chorionic gonadotropin
- Luteinizing hormone
- Menotropin
- Urofollitropin
|
|
| Antigonadotropins |
- Sex steroids (via negative feedback on the HPG axis): Androgens (incl. anabolic steroids, e.g., nandrolone, oxandrolone)
- Estrogens
- Progestogens (incl., allylestrenol, chlormadinone acetate, cyproterone acetate, delmadinone acetate, dydrogesterone, medroxyprogesterone acetate, megestrol acetate, nomegestrol acetate, norethisterone acetate, progesterone, spironolactone)
- Steroid synthesis inhibitors: Danazol
- Gestrinone
|
|
|
| GnRH inhibitors |
| Agonists |
- Buserelin
- Deslorelin
- GnRH (gonadorelin)
- Goserelin
- Histrelin
- Leuprorelin
- Nafarelin
- Triptorelin
|
|
| Antagonists |
- Abarelix
- Cetrorelix
- Degarelix
- Elagolix†
- Ganirelix
- Relugolix§
|
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
Index of reproductive medicine
|
|
| Description |
- Anatomy
- Physiology
- Development
- sex determination and differentiation
|
|
| Disease |
- Infections
- Congenital
- Neoplasms and cancer
- male
- female
- gonadal
- germ cell
- Other
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- benign prostatic hypertrophy
- erectile dysfunction and premature ejaculation
- sexual dysfunction
- infection
- hormones
- androgens
- estrogens
- progestogens
- GnRH
- prolactin
- Assisted reproduction
- Birth control
|
|
|
UpToDate Contents
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English Journal
- Sequential Versus Continual Purified Urinary FSH/hCG in Men With Idiopathic Hypogonadotropic Hypogonadism.
- Zhang M1, Tong G1, Liu Y1, Mu Y1, Weng J1, Xue Y1, Luo Z1, Xue Y1, Shi L1, Wu X1, Sun S1, Zhu Y1, Cao Y1, Zhang J1, Huang H1, Niu B1, Li H1, Guo Q1, Gao Y1, Li Z1, Ning G1, Zhu D1, Li X1; HHIS Study Group.
- The Journal of clinical endocrinology and metabolism.J Clin Endocrinol Metab.2015 Jun;100(6):2449-55. doi: 10.1210/jc.2014-3802. Epub 2015 Mar 31.
- CONTEXT: Gonadotropin therapy using a human chorionic gonadotropin (hCG) and FSH preparation is an effective regimen in inducing masculinization and spermatogenesis in men with idiopathic hypogonadotropic hypogonadism (IHH). However, the high cost of medication and frequent injections affect complia
- PMID 25825944
- Androgen receptor CAG repeat length is associated with ovarian reserve but not with ovarian response.
- Lledó B1, Llácer J2, Turienzo A3, Ortiz JA3, Guerrero J2, Morales R3, Ten J2, Bernabeu R4.
- Reproductive biomedicine online.Reprod Biomed Online.2014 Oct;29(4):509-15. doi: 10.1016/j.rbmo.2014.06.012. Epub 2014 Jul 9.
- The human androgen receptor (AR) gene contains a highly polymorphic CAG repeat sequence within exon 1. In-vitro studies have shown a relationship between CAG repeats in the AR gene and its transactivation potential. This variation in length may play a role in anovulatory infertility. The objective o
- PMID 25131556
- Spermatid count as a predictor of response to FSH therapy.
- Garolla A1, Selice R1, Engl B2, Bertoldo A1, Menegazzo M1, Finos L3, Lenzi A4, Foresta C5.
- Reproductive biomedicine online.Reprod Biomed Online.2014 Jul;29(1):102-12. doi: 10.1016/j.rbmo.2014.02.014. Epub 2014 Mar 15.
- This study evaluated the predictive power of spermatid count and cytology for assisted reproduction outcome after FSH therapy. A total of 174 men with severe oligozoospermia and normal plasma FSH concentration underwent semen analysis including spermatid count, TUNEL test, FISH analysis for sperm an
- PMID 24816256
Japanese Journal
- Recombinant follicle-stimulating hormone (follitropin alfa) versus purified urinary follicle-stimulating hormone in a low-dose step-up regimen to induce ovulation in Japanese women with anti-estrogen-ineffective oligo- or anovulatory infertility : results of a single-blind Phase III study
Related Links
- Urofollitropin is a purified form of follicle-stimulating hormone (FSH) that is manufactured by extraction from human urine and then purified to remove various proteins and other substances. FSH is important in the development of follicles (eggs) ...
- Find patient medical information for urofollitropin (FSH) Inj on WebMD including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
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