urodilatin

Urodilatin
Identifiers
CAS Registry Number	115966-23-9 ; 118812-69-4 (ularitide)
ChemSpider	17289074; 11209147
	InChI InChI=1S/C145H234N52O44S3/c1-11-72(6)112-137(238)171-60-106(208)172-73(7)113(214)177-86(40-41-103(146)205)122(223)190-95(63-198)116(217)170-61-108(210)175-88(51-70(2)3)114(215)169-62-109(211)176-100(133(234)187-92(56-104(147)206)127(228)193-97(65-200)130(231)186-91(54-77-27-16-13-17-28-77)126(227)180-82(31-20-45-163-142(153)154)119(220)189-94(139(240)241)55-78-36-38-79(204)39-37-78)68-243-244-69-101(134(235)185-90(53-76-25-14-12-15-26-76)115(216)168-58-105(207)167-59-107(209)174-80(29-18-43-161-140(149)150)117(218)182-87(42-50-242-10)123(224)188-93(57-110(212)213)128(229)181-85(124(225)196-112)34-23-48-166-145(159)160)195-132(233)99(67-202)194-131(232)98(66-201)192-120(221)83(32-21-46-164-143(155)156)178-118(219)81(30-19-44-162-141(151)152)179-125(226)89(52-71(4)5)184-129(230)96(64-199)191-121(222)84(33-22-47-165-144(157)158)183-135(236)102-35-24-49-197(102)138(239)74(8)173-136(237)111(148)75(9)203/h12-17,25-28,36-39,70-75,80-102,111-112,198-204H,11,18-24,29-35,40-69,148H2,1-10H3,(H2,146,205)(H2,147,206)(H,167,207)(H,168,216)(H,169,215)(H,170,217)(H,171,238)(H,172,208)(H,173,237)(H,174,209)(H,175,210)(H,176,211)(H,177,214)(H,178,219)(H,179,226)(H,180,227)(H,181,229)(H,182,218)(H,183,236)(H,184,230)(H,185,235)(H,186,231)(H,187,234)(H,188,224)(H,189,220)(H,190,223)(H,191,222)(H,192,221)(H,193,228)(H,194,232)(H,195,233)(H,196,225)(H,212,213)(H,240,241)(H4,149,150,161)(H4,151,152,162)(H4,153,154,163)(H4,155,156,164)(H4,157,158,165)(H4,159,160,166)/t72-,73-,74-,75+,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,111-,112-/m0/s1 ;
Jmol-3D images	Image
KEGG	C16000
MeSH	Urodilatin
PubChem	16132416
	SMILES CCC(C)C1C(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NCC(=O)NC(CSSCC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)CCCNC(=N)N)CC(=O)O)CCSC)CCCNC(=N)N)Cc2ccccc2)NC(=O)C(CO)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC(C)C)NC(=O)C(CO)NC(=O)C(CCCNC(=N)N)NC(=O)C3CCCN3C(=O)C(C)NC(=O)C(C(C)O)N)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(Cc4ccccc4)C(=O)NC(CCCNC(=N)N)C(=O)NC(Cc5ccc(cc5)O)C(=O)O)CC(C)C)CO)CCC(=O)N)C ;
UNII	GZ8FA500J0
Properties
Chemical formula	C145H234N52O44S3
Molar mass	3505.926
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	Infobox references

関: atrial natriuretic peptide

関: atrial natriuretic peptide

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/23 04:08:50」(JST)

wiki en

[Wiki en表示]

Urodilatin is a hormone that causes diuresis through increasing renal blood flow. It is secreted in response to increased mean arterial pressure and increased blood volume from the cells of the distal tubule and collecting duct. It is important in oliguric patients (such as those with acute renal failure and chronic renal failure) as it lowers serum creatinine and increases urine output.

Interactions of Urodilatin

Atrial natriuretic peptide (CDD/ANP-99-126)^[1] is a hormone system of clinical importance. Urodilatin (CDD/ ANP-95-126) is a homologue natriuretic peptide that differs from CDD/ANP-99-126 which is excreted into the circulation via exocytosis. The prototype of the natriuretic hormones is cardiodilatin/atrial natriuretic peptide (CDD/ANP).^[2] The endocrine heart is composed of specific myoendocrine cells that synthesize and secrete the natriuretic peptide hormones which exhibit diuretic, and vasorelaxant properties; secretion is the basis for a paracrine system regulating water and sodium reabsorption.^[3] Research efforts since the early 1980s have studied their effects on electrolyte homeostasis.^[4] When administered intravenously, URO induces strong diuresis and natriuresis with tolerable hemodynamic side effects.^[5] Urodilatin is localized in the kidney, differentially processed (involved in the regulation of body fluid volume and water-electrolyte excretion, while circulating), and secreted into the urine.^[5] As a consequence, urodilatin is involved in drug development along with the prohormone CDD/ANP-1-126 ^[2] and cardiodilatin CDD/ANP-99-126.^[3] A message for the preprohormone is transcribed in the heart and kidneys from the gene of NP type A, resulting in a cGMP-dependent signal transduction which induces diuresis and natriuresis,^[6] differentially processed to a peptide of 32 amino acids from the same precursor as renal ANP, may not be identical to the circulating cardiac hormone ANP.^[7] The kidneys produce their own natriuretic 32-residue peptide. Urodilatin renal natriuretic peptide potency equals or exceeds that of Atriopeptin [ANP-(99-126)], the prototype of cardiodilatin.^[8] Atriopeptin is only of trivial importance in the regulation of sodium excretion during normal living conditions.^[9] Urodilatin is little affected by renal enzymes that inactivate atriopeptin, as the kidney elutes with urodilatin rather than with ANP.^[10] The degradation rates of (125I)-urodilatin and [125I]-ANP by pure recombinant NEP (rNEP) were compared. Phosphoramidon, a potent inhibitor of NEP, completely protected both peptides from metabolism by rNEP.^[11] Urodilatin, has a four-residue extension at the N-terminus neutral endopeptidase-24.11 (NEP) plays a physiological role in metabolizing atrial natriuretic peptide, and C-type natriuretic peptide (prohormone) degraded the bioactive peptides at about half the rate though the C-terminal that compete with natriuretic peptides for hydrolysis by neutral endopeptidase.^[12]

References

^ Gagelmann M, Hock D, Forssmann WG. (June 1988). "Urodilatin (CDD/ANP-95-126) is not biologically inactivated by a peptidase from dog kidney cortex membranes in contrast to atrial natriuretic peptide/cardiodilatin (alpha-hANP/CDD-99-126).". FEBS Lett. 20 (223(2)): 249–54. doi:10.1016/0014-5793(88)80436-8. PMID 2968281.
^ ^a ^b Meyer M, Stief CG, Becker AJ, Truss MC, Taher A, Jonas U, Forssmann WG. (June 1988). "The renal paracrine peptide system--possible urologic implications of urodilatin.". World J Urol. 14 (2): 249–54. doi:10.1007/BF00183118. ISSN 0724-4983. PMID 8986039.
^ ^a ^b Forssmann WG, Richter R, Meyer M. (October 1998). "The endocrine heart and natriuretic peptides: histochemistry, cell biology, and functional aspects of the renal urodilatin system.". Histochem Cell Biol 110 (4): 335–57. doi:10.1007/s004180050295. PMID 9792413.
^ Meyer M, Schulz-Knappe P, Kuse ER, Hummel M, Hetzer R, Pichlmayr R, Forssmann WG. (February 1995). "[Urodilatin. Use of a new peptide in intensive care]". Anaesthesist. 44 (2): 81–91. doi:10.1007/s001010050135. PMID 7702187.
^ ^a ^b Kuse ER, Meyer M, Constantin R, Oldhafer K, Schlitt HJ, Schulz-Knappe P, Uberbacher HJ, Pichlmayr R, Forssmann WG. (April 1996). "[Urodilatin (INN: ularitide). A new peptide in the treatment of acute kidney failure following liver transplantation]". Anaesthesist. 45 (4): 351–8. doi:10.1007/s001010050271. PMID 8702053.
^ Meyer M, Richter R, Forssmann WG. (October 1998). "Urodilatin, a natriuretic peptide with clinical implications.". Eur J Med Res. 3 (1–2): 103–110. PMID 9512977.
^ Forssmann W, Meyer M, Forssmann K. (August 2001). "The renal urodilatin system: clinical implications.". Cardiovasc Res. 51 (3): 450–62. doi:10.1016/S0008-6363(01)00331-5. PMID 11476735.
^ Goetz KL. (December 1991). "Renal natriuretic peptide (urodilatin?) and atriopeptin: evolving concepts.". Am J Physiol. 261 (6): 921–32. PMID 1836308.
^ Goetz KL. (December 1993). "Is urodilatin (rather than atriopeptin) the primary natriuretic peptide of the ANP family?". J Cardiovasc Pharmacol. 22 (6): 911–913. doi:10.1097/00005344-199322002-00027. PMID 7508039.
^ Goetz K, Drummer C, Zhu JL, Leadley R, Fiedler F, Gerzer R. (December 1990). "Evidence that urodilatin, rather than ANP, regulates renal sodium excretion.". J Am Soc Nephrol. 1 (6): 867–74. ISSN 1533-3450. PMID 1966524.
^ Abassi ZA, Golomb E, Agbaria R, Roller PP, Tate J, Keiser HR. (September 1994). "Hydrolysis of iodine labelled urodilatin and ANP by recombinant neutral endopeptidase EC. 3.4.24.11.". Br J Pharmacol. 113 (1): 204–208. doi:10.1111/j.1476-5381.1994.tb16194.x. PMC 1510039. PMID 7812611.
^ Kenny AJ, Bourne A, Ingram J. (April 1998). "Hydrolysis of human and pig brain natriuretic peptides, urodilatin, C-type natriuretic peptide and some C-receptor ligands by endopeptidase-24.11.". Biochem J. 1 (291): 83–8. PMC 1132484. PMID 8097089.

UpToDate Contents

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1. ネフローゼ症候群患者における浮腫の病態生理学および治療 pathophysiology and treatment of edema in patients with the nephrotic syndrome
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3. 虚血後（虚血性）の急性尿細管壊死の発症および病因 pathogenesis and etiology of postischemic ischemic acute tubular necrosis

English Journal

Novel drug targets in clinical development for heart failure.

George M1, Rajaram M, Shanmugam E, Vijayakumar TM.
European journal of clinical pharmacology.Eur J Clin Pharmacol.2014 Apr 9. [Epub ahead of print]
BACKGROUND: Heart Failure continues to be a leading cause of mortality and morbidity worldwide. The dismal prognosis of patients in acute heart failure (AHF) can be altered only by exploring novel drug molecules. Although the treatment for chronic heart failure (CHF) has seen remarkable progress, th
PMID 24710739

Urodilatin regulates renal dopamine metabolism.

Choi MR1, Citarella MR, Lee BM, Kouyoumdzian NM, Rukavina Mikusic NL, Fernández BE.
Journal of nephrology.J Nephrol.2013 Nov-Dec;26(6):1042-8. doi: 10.5301/jn.5000279. Epub 2013 May 6.
BACKGROUND: Sodium and water transport across renal proximal tubules is regulated by diverse hormones such as dopamine and urodilatin. We have previously reported that urodilatin stimulates extraneuronal dopamine uptake in external renal cortex by activation of the type A natriuretic peptide recepto
PMID 23661592

Acute decompensated heart failure: update on new and emerging evidence and directions for future research.

Givertz MM1, Teerlink JR, Albert NM, Westlake Canary CA, Collins SP, Colvin-Adams M, Ezekowitz JA, Fang JC, Hernandez AF, Katz SD, Krishnamani R, Stough WG, Walsh MN, Butler J, Carson PE, Dimarco JP, Hershberger RE, Rogers JG, Spertus JA, Stevenson WG, Sweitzer NK, Tang WH, Starling RC.
Journal of cardiac failure.J Card Fail.2013 Jun;19(6):371-89. doi: 10.1016/j.cardfail.2013.04.002.
Acute decompensated heart failure (ADHF) is a complex clinical event associated with excess morbidity and mortality. Managing ADHF patients is challenging because of the lack of effective treatments that both reduce symptoms and improve clinical outcomes. Existing guideline recommendations are large
PMID 23743486

Japanese Journal

Hydrolysis of human and pig brain natriuretic peptides, urodilatin, C-type natriuretic peptide and some C-receptor ligands by endopeptidase-24.11

KENNY AJ.
Biochem J 291, 83-88, 1993
NAID 80006997989

Urodilatin : a new peptide with beneficial effects in the postoperative therapy of cardiac transplant recipients

HUMMEL M
Clin Invest 70, 674-682, 1992
NAID 30012990767

Related Pictures

(PDF) The endocrine heart and natriuretic peptides: Histochemistry, cell biology, and Endokrinné srdce. Natriuretické peptidy, ich význam a využitie v diagnostike a Schematic drawing of the role of urodilatin under physiological and | Download Ularitide this time it is different. Natriuretic peptides (NP) in schematic depiction. Note the prohormone | Download CAS No.115966-23-9,Urodilatin Suppliers

[pmid2968281-1] Gagelmann M, Hock D, Forssmann WG. (June 1988). "Urodilatin (CDD/ANP-95-126) is not biologically inactivated by a peptidase from dog kidney cortex membranes in contrast to atrial natriuretic peptide/cardiodilatin (alpha-hANP/CDD-99-126).". FEBS Lett. 20 (223(2)): 249–54. doi:10.1016/0014-5793(88)80436-8. PMID 2968281.

[pmid8986039-2] Meyer M, Stief CG, Becker AJ, Truss MC, Taher A, Jonas U, Forssmann WG. (June 1988). "The renal paracrine peptide system--possible urologic implications of urodilatin.". World J Urol. 14 (2): 249–54. doi:10.1007/BF00183118. ISSN 0724-4983. PMID 8986039.

[pmid9792413-3] Forssmann WG, Richter R, Meyer M. (October 1998). "The endocrine heart and natriuretic peptides: histochemistry, cell biology, and functional aspects of the renal urodilatin system.". Histochem Cell Biol 110 (4): 335–57. doi:10.1007/s004180050295. PMID 9792413.

[pmid7702187-4] Meyer M, Schulz-Knappe P, Kuse ER, Hummel M, Hetzer R, Pichlmayr R, Forssmann WG. (February 1995). "[Urodilatin. Use of a new peptide in intensive care]". Anaesthesist. 44 (2): 81–91. doi:10.1007/s001010050135. PMID 7702187.

[pmid8702053-5] Kuse ER, Meyer M, Constantin R, Oldhafer K, Schlitt HJ, Schulz-Knappe P, Uberbacher HJ, Pichlmayr R, Forssmann WG. (April 1996). "[Urodilatin (INN: ularitide). A new peptide in the treatment of acute kidney failure following liver transplantation]". Anaesthesist. 45 (4): 351–8. doi:10.1007/s001010050271. PMID 8702053.

[pmid9512977-6] Meyer M, Richter R, Forssmann WG. (October 1998). "Urodilatin, a natriuretic peptide with clinical implications.". Eur J Med Res. 3 (1–2): 103–110. PMID 9512977.

[pmid11476735-7] Forssmann W, Meyer M, Forssmann K. (August 2001). "The renal urodilatin system: clinical implications.". Cardiovasc Res. 51 (3): 450–62. doi:10.1016/S0008-6363(01)00331-5. PMID 11476735.

[pmid1836308-8] Goetz KL. (December 1991). "Renal natriuretic peptide (urodilatin?) and atriopeptin: evolving concepts.". Am J Physiol. 261 (6): 921–32. PMID 1836308.

[pmid7508039-9] Goetz KL. (December 1993). "Is urodilatin (rather than atriopeptin) the primary natriuretic peptide of the ANP family?". J Cardiovasc Pharmacol. 22 (6): 911–913. doi:10.1097/00005344-199322002-00027. PMID 7508039.

[pmid1966524-10] Goetz K, Drummer C, Zhu JL, Leadley R, Fiedler F, Gerzer R. (December 1990). "Evidence that urodilatin, rather than ANP, regulates renal sodium excretion.". J Am Soc Nephrol. 1 (6): 867–74. ISSN 1533-3450. PMID 1966524.

[pmid7812611-11] Abassi ZA, Golomb E, Agbaria R, Roller PP, Tate J, Keiser HR. (September 1994). "Hydrolysis of iodine labelled urodilatin and ANP by recombinant neutral endopeptidase EC. 3.4.24.11.". Br J Pharmacol. 113 (1): 204–208. doi:10.1111/j.1476-5381.1994.tb16194.x. PMC 1510039. PMID 7812611.

[pmid8097089-12] Kenny AJ, Bourne A, Ingram J. (April 1998). "Hydrolysis of human and pig brain natriuretic peptides, urodilatin, C-type natriuretic peptide and some C-receptor ligands by endopeptidase-24.11.". Biochem J. 1 (291): 83–8. PMC 1132484. PMID 8097089.

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