ウロカニン酸ヒドラターゼ
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/07/13 12:39:36」(JST)
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Urocanase
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| Crystal structure of Urocanase from B. subtilis. |
| Identifiers |
| Symbol |
Urocanase |
| Pfam |
PF01175 |
| InterPro |
IPR000193 |
| PROSITE |
PDOC00947 |
| Available protein structures: |
| Pfam |
structures |
| PDB |
RCSB PDB; PDBe |
| PDBsum |
structure summary |
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Imidazol-4-one-5-propionic acid
Urocanase[1] (also known as imidazolonepropionate hydrolase or urocanate hydratase) is the enzyme that catalyzes the second step in the degradation of histidine, the hydration of urocanate into imidazolonepropionate.
- urocanate + H2O 4,5-dihydro-4-oxo-5-imidazolepropanoate
Inherited deficiency of urocanase leads to elevated levels of urocanic acid in the urine, a condition known as urocanic aciduria.
Urocanase is found in some bacteria (gene hutU), in the liver of many vertebrates and has also been found in the plant Trifolium repens (white clover). Urocanase is a protein of about 60 Kd, it binds tightly to NAD+ and uses it as an electrophil cofactor. A conserved cysteine has been found to be important for the catalytic mechanism and could be involved in the binding of the NAD+.
References
- ^ Retey J (1994). "The urocanase story: a novel role of NAD+ as electrophile". Arch. Biochem. Biophys. 314 (1): 1–16. DOI:10.1006/abbi.1994.1405. PMID 7944380.
External links
- Urocanate+Hydratase at the US National Library of Medicine Medical Subject Headings (MeSH)
- EC 4.2.1.49
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Carbon-oxygen lyases (EC 4.2) (primarily dehydratases)
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| 4.2.1: Hydro-Lyases |
Carbonic anhydrase - Fumarase - Aconitase - Enolase (Alpha, Enolase 2) - Enoyl-CoA hydratase/3-Hydroxyacyl ACP dehydrase - Methylglutaconyl-CoA hydratase - Tryptophan synthase - Cystathionine beta synthase - Porphobilinogen synthase - 3-isopropylmalate dehydratase - Urocanate hydratase - Uroporphyrinogen III synthase - Nitrile hydratase
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| 4.2.2: Acting on polysaccharides |
Hyaluronate lyase
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| 4.2.3: Acting on phosphates |
Threonine synthase
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| 4.2.99: Other |
Carboxymethyloxysuccinate lyase
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- B
- enzm
- 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 2.7.10
- 2.7.11-12
- 3.1
- 3.1.3.48
- 3.4.21
- 4.1
- 5.1
- 6.1-3
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Metabolism: amino acid metabolism · synthesis and catabolism enzymes (essential in CAPS)
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| K→acetyl-CoA |
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LYSINE→
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- Saccharopine dehydrogenase
- Glutaryl-CoA dehydrogenase
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LEUCINE→
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- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Isovaleryl coenzyme A dehydrogenase
- Methylcrotonyl-CoA carboxylase
- Methylglutaconyl-CoA hydratase
- 3-hydroxy-3-methylglutaryl-CoA lyase
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TRYPTOPHAN→
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- Indoleamine 2,3-dioxygenase/Tryptophan 2,3-dioxygenase
- Arylformamidase
- Kynureninase
- 3-hydroxyanthranilate oxidase
- Aminocarboxymuconate-semialdehyde decarboxylase
- Aminomuconate-semialdehyde dehydrogenase
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PHENYLALANINE→tyrosine→
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(see below)
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| G |
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G→pyruvate
→citrate
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glycine→serine→
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- Serine hydroxymethyltransferase
- Serine dehydratase
- glycine→creatine: Guanidinoacetate N-methyltransferase
- Creatine kinase
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alanine→
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cysteine→
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threonine→
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- L-threonine dehydrogenase
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G→glutamate→
α-ketoglutarate
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HISTIDINE→
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- Histidine ammonia-lyase
- Urocanate hydratase
- Formiminotransferase cyclodeaminase
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proline→
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- Proline oxidase
- Pyrroline-5-carboxylate reductase
- 1-Pyrroline-5-carboxylate dehydrogenase/ALDH4A1
- PYCR1
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arginine→
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- Ornithine aminotransferase
- Ornithine decarboxylase
- Agmatinase
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→alpha-ketoglutarate→TCA
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Other
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- cysteine+glutamate→glutathione: Gamma-glutamylcysteine synthetase
- Glutathione synthetase
- Gamma-glutamyl transpeptidase
- glutamate→glutamine: Glutamine synthetase
- Glutaminase
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G→propionyl-CoA→
succinyl-CoA
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VALINE→
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- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- Enoyl-CoA hydratase
- 3-hydroxyisobutyryl-CoA hydrolase
- 3-hydroxyisobutyrate dehydrogenase
- Methylmalonate semialdehyde dehydrogenase
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ISOLEUCINE→
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- Branched chain aminotransferase
- Branched-chain alpha-keto acid dehydrogenase complex
- 3-hydroxy-2-methylbutyryl-CoA dehydrogenase
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METHIONINE→
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- generation of homocysteine: Methionine adenosyltransferase
- Adenosylhomocysteinase
- regeneration of methionine: Methionine synthase/Homocysteine methyltransferase
- Betaine-homocysteine methyltransferase
- conversion to cysteine: Cystathionine beta synthase
- Cystathionine gamma-lyase
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THREONINE→
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→succinyl-CoA→TCA
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- Propionyl-CoA carboxylase
- Methylmalonyl CoA epimerase
- Methylmalonyl-CoA mutase
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G→fumarate
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PHENYLALANINE→tyrosine→
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- Phenylalanine hydroxylase
- Tyrosine aminotransferase
- 4-Hydroxyphenylpyruvate dioxygenase
- Homogentisate 1,2-dioxygenase
- Fumarylacetoacetate hydrolase
- tyrosine→melanin: Tyrosinase
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G→oxaloacetate
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asparagine→aspartate→
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- Asparaginase/Asparagine synthetase
- Aspartate transaminase
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mt, k, c/g/r/p/y/i, f/h/s/l/o/e, a/u, n, m
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k, cgrp/y/i, f/h/s/l/o/e, au, n, m, epon
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m(A16/C10),i(k, c/g/r/p/y/i, f/h/s/o/e, a/u, n, m)
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UpToDate Contents
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English Journal
- Radiation-Resistant Micrococcus luteus SC1204 and Its Proteomics Change Upon Gamma Irradiation.
- Deng W1,2, Yang Y1, Gao P3,4, Chen H3, Wen W1, Sun Q5.
- Current microbiology.Curr Microbiol.2016 Jun;72(6):767-75. doi: 10.1007/s00284-016-1015-y. Epub 2016 Feb 26.
- PMID 26920868
- Mutations in the urocanase gene UROC1 are associated with urocanic aciduria.
- Espinós C1, Pineda M, Martínez-Rubio D, Lupo V, Ormazabal A, Vilaseca MA, Spaapen LJ, Palau F, Artuch R.
- Journal of medical genetics.J Med Genet.2009 Jun;46(6):407-11. doi: 10.1136/jmg.2008.060632. Epub 2009 Mar 19.
- PMID 19304569
- A variety of electrostatic interactions and adducts can activate NAD(P) cofactors for hydride transfer.
- Meijers R1, Cedergren-Zeppezauer E.
- Chemico-biological interactions.Chem Biol Interact.2009 Mar 16;178(1-3):24-8. doi: 10.1016/j.cbi.2008.10.043. Epub 2008 Nov 5.
- PMID 19028476
Related Links
- Urocanate hydratase (hutU), Urocanate hydratase Imidazolonepropionase This subpathway is part of the pathway L-histidine degradation into L-glutamate, which is itself part of Amino-acid degradation. View all proteins of thisN- . ...
- cytosol, urocanate hydratase activity, histidine catabolic process UniProtKB x UniProtKB Protein knowledgebase UniParc Sequence archive Help Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration ...
★リンクテーブル★
[★]
ヒドラターゼ、水添加酵素、加水酵素
- 関
- hydrase