WordNet

lacking stability or fixity or firmness; "unstable political conditions"; "the tower proved to be unstable in the high wind"; "an unstable world economy"
disposed to psychological variability; "his rather unstable religious convictions"
highly or violently reactive; "sensitive and highly unstable compounds"
a blood disease characterized by the presence of abnormal hemoglobins in the blood (同)haemoglobinopathy

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1. 不安定ヘモグロビン変異体 unstable hemoglobin variants
2. 異常ヘモグロビン症の検査室診断 laboratory diagnosis of the hemoglobinopathies
3. 異常ヘモグロビン症およびサラセミアの出生前検査 prenatal testing for the hemoglobinopathies and thalassemias
4. ヘモグロビン変異の概要 introduction to hemoglobin mutations
5. 異型鎌状赤血球症候群 variant sickle cell syndromes

Thalassemia-like phenotype in a novel complex hemoglobinopathy With α, β, δ globin chain abnormalities.

Sabio H, Dixon N, Patel N, Obiaga C, Zhuang L, Meiler SE, Kutlar A, Kutlar F.SourceDepartment of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Journal of pediatric hematology/oncology.J Pediatr Hematol Oncol.2011 Dec;33(8):589-91.
The occurrence of multiple abnormalities of α, β, δ, and γ globin genes may lead to unusual and complex phenotypes when they arise simultaneously in the same individual. Here, we report the findings of an African American boy who coinherited 3 heterozygous globin gene abnormalities: the unstable
PMID 22042275

The second mini-transplant for unstable mixed chimerism within the first 100 days after hematopoietic stem cell transplant in severe thalassemia.

Choeyprasert W, Pakakasama S, Anurathapan U, Songdej D, Sirachainun N, Sirireung S, Panthangkool W, Hongeng S.SourceDepartment of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Pediatric transplantation.Pediatr Transplant.2011 Sep 5. doi: 10.1111/j.1399-3046.2011.01577.x. [Epub ahead of print]
Choeyprasert W, Pakakasama S, Anurathapan U, Songdej D, Sirachainun N, Sirireung S, Panthangkool W, Hongeng S. The second mini-transplant for unstable mixed chimerism within the first 100 days after hematopoietic stem cell transplant in severe thalassemia. Pediatr Transplantation 2011. © 2011 Joh
PMID 21895905

Ropero P, Martín-Nuñez G, González FA, Villegas A, de la Fuente-Gonzalo F, Martínez-Nieto J, Vinuesa L, Díaz-Mediavilla J.SourceHematology Service, Hospital Clínico San Carlos, Madrid, Spain. propero.hcsc@salud.madrid.org
Hemoglobin.Hemoglobin.2011;35(4):423-7.
Unstable hemoglobin (Hb) variants account for 9.5% of structural hemoglobinopathies. The majority of these unstable variants are the result of gene point mutations resulting in the substitution of a single amino acid by another. The presence of two mutations in the same allele is infrequent: of the
PMID 21797709

Ohba Yuzo
The bulletin of the Yamaguchi Medical School 46(3-4), 61-69, 1999-12
… Hb Ms as a couse of herediatary nigremia marked the first stage of hemoglobinopahthy research in Japan, and a variety of unstable hemoglobins causing hemolytic disease the second stage. … Virtually all types of abnormal Hbs were found among Japanese: hereditary nigremia, unstable Hb hemolytic disease, hyperunatable Hb disease mimicking a relatively severe form of thalassemia sydrom sydrome, hereditary erythremia due to high oxygen affinity Hbs, and so on. …
NAID 120000863911

伊東重義,久保章,高橋利通,鈴木良人,松井孝輔
日本消化器外科学会雑誌 24(1), 119-123, 1991-01-01
球状赤血球症をはじめとする溶血性疾患に胆石症が合併することは多く報告されており, その外科的治療についても検討されている. しかし不安定ヘモグロビン症に合併する胆石症についての報告はほとんど見られない. 今回不安定ヘモグロビン症で脾臓摘出後出後に胆嚢胆管結石を合併した症例を経験したので報告する. 症例は17歳, 男性で, 不安定ヘモグロビン症のため4歳時に脾臓摘出をうけている. 上腹部痛を主訴に受 …
NAID 110001323076