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English Journal

DNA methylation detection by a novel fluorimetric nanobiosensor for early cancer diagnosis.

Dadmehr M1, Hosseini M2, Hosseinkhani S3, Ganjali MR4, Khoobi M5, Behzadi H6, Hamedani M7, Sheikhnejad R7.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Oct 15;60:35-44. doi: 10.1016/j.bios.2014.03.033. Epub 2014 Apr 15.
A very sensitive and convenient fluorescence nanobiosensor for rapid detection of DNA methylation based on Fe3O4/Au core/shell nanoparticles has been developed. Specific site of CpG islands of adenomatous polyposis coli (APC), a well studied tumor suppressor gene, was used as the detection target DN
PMID 24768860

F0 maternal BPA exposure induced glucose intolerance of F2 generation through DNA methylation change in Gck.

Li G1, Chang H1, Xia W1, Mao Z1, Li Y1, Xu S2.
Toxicology letters.Toxicol Lett.2014 Aug 4;228(3):192-9. doi: 10.1016/j.toxlet.2014.04.012. Epub 2014 May 1.
BPA, a common environmental endocrine disruptor, has been reported to induce epigenetic changes and disrupt glucose homeostasis in F1 offspring through maternal exposure. However, no studies have examined whether maternal BPA exposure can exert multigenerational effects of glucose metabolic disorder
PMID 24793715

Prevalence and Clinicopathologic Correlates of O(6)-Methylguanine-DNA Methyltransferase Methylation Status in Patients With Triple-Negative Breast Cancer Treated Preoperatively by Alkylating Drugs.

Fumagalli C1, Della Pasqua S2, Bagnardi V3, Cardillo A2, Sporchia A2, Colleoni M2, Viale G4, Barberis M1, Pruneri G5.
Clinical breast cancer.Clin Breast Cancer.2014 Aug;14(4):285-90. doi: 10.1016/j.clbc.2014.02.010. Epub 2014 Mar 2.
BACKGROUND: Predictive factors of benefit from specific chemotherapy regimens are not currently available in triple-negative breast cancer (TNBC). MGMT (O(6)-methylguanine-DNA methyltransferase) controls DNA repair pathways, and its epigenetic silencing is used for predicting the response to the alk
PMID 24709436

Nasal delivery of Japanese cedar pollen Cryj1 by using self-gelling immunostimulatory DNA for effective induction of immune responses in mice.

Middle-Down and Chemical Proteomic Approaches to Reveal Histone H4 Modification Dynamics in Cell Cycle:Label-Free Semi-Quantification of Histone Tail Peptide Modifications Including Phosphorylation and Highly Sensitive Capture of Histone PTM Binding Proteins Using Photo-Reactive Crosslinkers