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English Journal

Memory of viral infections by CRISPR-Cas adaptive immune systems: Acquisition of new information.

Fineran PC, Charpentier E.SourceDepartment of Microbiology and Immunology, University of Otago, PO Box 56, Dunedin 9054, New Zealand. Electronic address: peter.fineran@otago.ac.nz.
Virology.Virology.2012 Dec 20;434(2):202-9. doi: 10.1016/j.virol.2012.10.003. Epub 2012 Nov 2.
Multiple organisms face the threat of viral infections. To combat phage invasion, bacteria and archaea have evolved an adaptive mechanism of protection against exogenic mobile genetic elements, called CRISPR-Cas. In this defense strategy, phage infection is memorized via acquisition of a short invad
PMID 23123013

Localization of pandemic 2009 H1N1 influenza A virus RNA in lung and lymph nodes of fatal influenza cases by in situ hybridization: New insights on virus replication and pathogenesis.

Bhatnagar J, Jones T, Blau DM, Shieh WJ, Paddock CD, Drew C, Denison AM, Rollin DC, Patel M, Zaki SR.SourceInfectious Diseases Pathology Branch, Division of High-Consequence Pathogens and Pathology, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA. Electronic address: JBhatnagar@cdc.gov.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.J Clin Virol.2012 Dec 13. pii: S1386-6532(12)00434-9. doi: 10.1016/j.jcv.2012.11.014. [Epub ahead of print]
BACKGROUND: Pandemic 2009 H1N1 influenza A (pH1N1) virus has caused substantial morbidity and mortality globally and continues to circulate. Although pH1N1 viral antigens have been demonstrated in various human tissues by immunohistochemistry (IHC), cellular localization of pH1N1 RNA in these tissue
PMID 23246358

Profiling mRNA of the Graying Human Hair Follicle Constitutes a Promising State-of-the-Art Tool to Assess Its Aging: An Exemplary Report.

Peters EM, Liezmann C, Spatz K, Ungethüm U, Kuban RJ, Daniltchenko M, Kruse J, Imfeld D, Klapp BF, Campiche R.Source1] Department of Psychosomatic Medicine, CharitéCenter 12 (CC12) for Internal Medicine and Dermatology, University-Medicine Charité, Berlin, Germany [2] Department of Psychosomatic Medicine and Psychotherapy, University Hospital Gießen and Marburg, Gießen, Germany.
The Journal of investigative dermatology.J Invest Dermatol.2012 Dec 13. doi: 10.1038/jid.2012.462. [Epub ahead of print]
Determining hitherto uninvestigated and safe targets to halt the aging process is important in our aging society. Graying is a hallmark of the aging process and may be used to identify aging tissue for comparative analysis. Here we analyzed differential gene expressions between pigmented, gray, and
PMID 23235529

M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells