American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2015 Jun 10:ajprenal.00438.2014. doi: 10.1152/ajprenal.00438.2014. [Epub ahead of print]
Modified vascular smooth muscle cells of the kidney afferent arterioles have recently been shown to serve as progenitors for glomerular epithelial cells in response to glomerular injury. To determine if such cells of renin lineage (CoRL) serve as progenitors for other cells in kidney disease charact
Metabolomic and lipidomic study of the protective effect of Chaihuang-Yishen formula on rats with diabetic nephropathy.
Zhao T1, Zhang H2, Zhang X1, Zhao T2, Lan HY3, Liang Q4, Luo G4, Li P5.
Journal of ethnopharmacology.J Ethnopharmacol.2015 May 26;166:31-41. doi: 10.1016/j.jep.2015.02.019. Epub 2015 Feb 17.
ETHNOPHARMACOLOGICAL RELEVANCE: Chaihuang-Yishen formula (CHYS) is a Chinese herbal formula that has been shown clinically to effectively treat chronic kidney disease including diabetic nephropathy (DN), also known as diabetic kidney disease. Our previous animal studies showed that numerous intraren
Hypertension research : official journal of the Japanese Society of Hypertension.Hypertens Res.2015 May;38(5):317-22. doi: 10.1038/hr.2015.13. Epub 2015 Feb 19.
Excess iron is associated with the pathogenesis of several renal diseases. Aldosterone is reported to have deleterious effects on the kidney, but there have been no reports of the role of iron in aldosterone/salt-induced renal injury. Therefore, we investigated the effects of dietary iron restrictio
A Novel Diabetes Mellitus Mouse Model, MAFA-Deficient and Beta Cell-Specific MAFK-Overexpressing Hybrid Transgenic Mice, Developed Severe Diabetic Nephropathy and Improved with TCV-116 (Candesartan Cilexetil) Treatment
… Previously, we reported that MAFA-deficient and beta cell-specific MAFK-overexpressing hybrid transgenic (Mafa–/–Mafk +) mice develop diabetes mellitus and, after uninephrectomy, demonstrate these characteristic lesions. … In this study, we administered TCV-116 (candesartan cilexetil) to Mafa–/–Mafk + mice after uninephrectomy and examined whether TCV-116 ameliorated the diabetic nephropathy. … We performed uninephrectomy of the Mafa–/–Mafk + mice at 8 weeks old. …
Compensatory Renal Growth in Uninephrectomized Immature Rats: Proliferative Activity and Epidermal Growth Factor
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Journal of Veterinary Medical Science 72(8), 975-980, 2010
… Compensatory response to uninephrectomy in immature animals is stronger compared with that in adult ones and the response is due mainly to renal cell proliferation. … The present study explored to show the growth pattern of the remaining kidney immediately after uninephrectomy in immature rats with special reference to proliferating activity and epidermal growth factor (EGF). …
uninephrectomy [u″nĭ-nef-rek´tah-me] surgical removal of a single kidney. ... 17] These abnormalities were associated with a more pronounced decrease in renal function after uninephrectomy, compared to patients with normal ...