English Journal

The effect of structural motifs on the ectodomain shedding of human angiotensin-converting enzyme.

Conrad N1, Schwager SL1, Carmona AK2, Sturrock ED3.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Dec 2;481(1-2):111-116. doi: 10.1016/j.bbrc.2016.10.155. Epub 2016 Nov 3.
Somatic angiotensin converting enzyme (sACE) is comprised of two homologous domains (N and C domains), whereas the smaller germinal isoform (tACE) is identical to the C domain. Both isozymes share an identical stalk, transmembrane and cytoplasmic domain, and undergo ectodomain shedding by an as yet
PMID 27818199

Presentation of underglycosylated mucin 1 in pancreatic adenocarcinoma (PDAC) at early stages.

Lo ST1, Pantazopouos P2, Medarova Z2, Moore A2.
American journal of cancer research.Am J Cancer Res.2016 Sep 1;6(9):1986-1995. eCollection 2016.
Underglycosylated mucin 1 antigen (uMUC1) is a proven biomarker of cancer progression relevant to many malignancies including pancreatic ductal adenocarcinoma (PDAC). However, while ample evidence exists of the expression of total MUC1, little is known about the abundance of the underglycolsylated f
PMID 27725904

BacMam production of active recombinant lecithin-cholesterol acyltransferase: Expression, purification and characterization.

Romanow WG1, Piper DE2, Fordstrom P3, Thibault S4, Zhou M3, Walker NP2.
Protein expression and purification.Protein Expr Purif.2016 Sep;125:1-6. doi: 10.1016/j.pep.2015.09.003. Epub 2015 Sep 9.
Lecithin-cholesterol acyltransferase (LCAT) is a key enzyme in the esterification of cholesterol and its subsequent incorporation into the core of high density lipoprotein (HDL) particles. It is also involved in reverse cholesterol transport (RCT), the mechanism by which cholesterol is removed from
PMID 26363122

Japanese Journal

Cytotoxic T lymphocytes derived from bone marrow mononuclear cells of multiple myeloma patients recognize an underglycosylated form of MUC1 mucin

NOTO Hisaya,TAKAHASHI Tohru,MAKIGUCHI Yusuke,HAYASHI Toshiaki,HINODA Yuji,IMAI Kohzoh
International immunology 9(5), 791-798, 1997-05
NAID 10005879158