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Ramalho SD1, de Sousa LR1, Burger MC1, Lima MI2, da Silva MF1, Fernandes JB1, Vieira PC1.
Natural product research.Nat Prod Res.2015 Dec;29(23):2212-4. doi: 10.1080/14786419.2014.1002404. Epub 2015 Jan 27.
Cathepsin B (catB) is a cysteine protease involved in tumour progression and represents a potential therapeutic target in cancer. Among the 15 evaluated extracts from cerrado biome, Myrcia lingua Berg. (Myrtaceae) extract demonstrated to be a source of compounds with potential to inhibit catB. Using
PMID 25622620

Constituents of the seeds of Cassia tora with inhibitory activity on soluble expoxide hydrolease.

Lee GY1, Kim JH2, Choi SK3, Kim YH4.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Nov 15;25(22):5097-101. doi: 10.1016/j.bmcl.2015.10.014. Epub 2015 Oct 8.
Efforts to extract soluble epoxide hydrolase (sEH) inhibitors from food sources through bioactivity-guided fractionation of Cassia tora seed extracts led to the isolation of one new compound, 1, and 15 known compounds, 2-16. Structural elucidations were performed using 1D/2D NMR spectroscopy and mas
PMID 26483136

Dihydroagarofuranoid Sesquiterpenes as Acetylcholinesterase Inhibitors from Celastraceae Plants: Maytenus disticha and Euonymus japonicus.

Alarcon J, Cespedes CL, Muñoz E, Balbontin C, Valdes F, Gutierrez M, Astudillo L, Seigler D.
Journal of agricultural and food chemistry.J Agric Food Chem.2015 Nov 6. [Epub ahead of print]
Natural cholinesterase inhibitors have been found in many biological sources. Nine compounds with agarofuran (epoxyeudesmane) skeletons were isolated from seeds and aerial part of Maytenus disticha and Euonymus japonicus. The identification and structural elucidation of compounds were based on spect
PMID 26545100

Selective purification of intestinal maltase complex by affinity chromatography employing an uncompetitive inhibitor as the ligand

Kato Eisuke,Tsuji Hiroki,Kawabata Jun
Tetrahedron 71(9), 1419-1424, 2015-03-04
… We synthesized and investigated the use of an uncompetitive inhibitor as an affinity ligand, to leverage its three-component interactions. … Use of the potent α-glucosidase uncompetitive inhibitor 2-aminoresorcinol as the ligand of the affinity gel offered selective purification of maltase-glucoamylase complex from the crude mixture of intestinal α-glucosidases. …
NAID 120005595709

The α-Glucosidase and α-Amylase Enzyme Inhibitory of Hydroxytyrosol and Oleuropein

伊藤昇,中島徹,菅井貴裕 [他],山際教之,嶋田(中島) 淳子,保坂公平,田中進
北関東医学 65(1), 53-59, 2015
背景・目的：先行研究において, 我々は, 直鎖アルキルベンゼンスルホン酸 (LAS) がホスホプロテインホスファターゼの一つであり, PP2Bとも呼ばれているカルシニューリン (CN) 活性の強力な阻害剤であることを報告した. 本研究ではLASのプロテインホスファターゼ1α (PP1α) 活性に対する阻害効果を検討し, その阻害様式を明らかとした.材料と方法：PP1αに対する, LASの阻害効果と …
NAID 130005060948