非代償性アルカローシス
WordNet
- abnormally high alkalinity (low hydrogen-ion concentration) of the blood and other body tissues
- not paying a salary; "an uncompensated federal post" (同)unsalaried
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Acetazolamide for the Management of Chronic Metabolic Alkalosis in Neonates and Infants.
- Tam B1, Chhay A, Yen L, Tesoriero L, Ramanathan R, Seri I, Friedlich PS.Author information 11The Center for Fetal and Neonatal Medicine, USC Division of Neonatal Medicine, Children's Hospital Los Angeles and the LAC + USC Medical Center, University of Southern California Keck School of Medicine 2University of Southern California School of Pharmacy 3Department of Pharmacy, Children's Hospital Los Angeles, Los Angeles, CA.AbstractIn this study, we evaluated the efficacy and safety of acetazolamide in the management of chronic metabolic alkalosis in neonates and infants with chronic respiratory insufficiency. A retrospective chart review of 90 patients treated with acetazolamide between 2006 and 2007 admitted to the neonatal intensive care unit was performed. Blood gases and electrolytes obtained at baseline and by 24 hours after acetazolamide administration were compared. Compared with baseline and after 24 hours of acetazolamide, mean measured serum bicarbonate (29.5 ± 3.7 vs. 26.9 ± 3.8 mEq/L, P < 0.001) and base excess (10.0 ± 3.4 vs. 4.8 ± 4.0 mEq/L, P < 0.001) were significantly lower. No significant differences in other electrolytes, blood urea nitrogen, and urine output were noted, except for an increased serum chloride and creatinine. Uncompensated respiratory acidosis developed in 4 (3.1%) treatment courses. Acetazolamide may be effective in decreasing serum bicarbonate in carefully selected patients. Its use and safety as an adjunctive therapy for chronic metabolic alkalosis in neonates and infants with chronic respiratory insufficiency needs further study.
- American journal of therapeutics.Am J Ther.2012 Sep 24. [Epub ahead of print]
- In this study, we evaluated the efficacy and safety of acetazolamide in the management of chronic metabolic alkalosis in neonates and infants with chronic respiratory insufficiency. A retrospective chart review of 90 patients treated with acetazolamide between 2006 and 2007 admitted to the neonatal
- PMID 23011176
- Acute adrenal crisis and hypercalcemia in a patient assuming high liquorice doses.
- Isaia GC1, Pellissetto C, Ravazzoli M, Tamone C.Author information 1Department of Internal Medicine, University of Turin, Turin, Italy. giancarlo.isaia@unito.itAbstractTwo months after monolateral adrenalectomy, a 47-year-old woman stopped taking corticosteroid replacement therapy in the first 15 days of therapy. She was admitted to the Department of Internal Medicine because of hypertension, severe hypercalcemia, uncompensated metabolic alkalosis and clinical symptoms of acute adrenal insufficiency. The presence of hypokalemia and hypernatremia precluded a diagnosis of hypocortisolism, therefore no corticosteroids were given during the time required to investigate the cause of hypercalcemia, which resulted negative. Administration of intravenous saline infusion produced no improvement in her clinical condition. Despite electrolyte alterations, hydrocortison (100 mg i.v.) and zoledronate (4 mg i.v.) were also administered, leading to a rapid and marked improvement in her clinical picture within a few hours, with normalization of the calcemia and the other electrolytic disturbances. After her neurological condition had fully normalized, the patient admitted she had been assuming large amounts of liquorice as a laxative for many years; this compound very likely compensated the adrenal insufficiency by inhibiting 11 b steroid-dehydrogenase and disguised the clinical presentation at the time of admission. This case report confirms that, though rare, hypercalcemia may be a finding in acute adrenal insufficiency and can be rapidly corrected by corticosteroid administration. Furthermore, excessive liquorice intake can induce a clinical picture resembling that of primary hyperaldosteronism. In patients with adrenal insufficiency, it can, at least in part, disguise its metabolic effects and delay diagnosis and treatment.
- Minerva medica.Minerva Med.2008 Feb;99(1):91-4.
- Two months after monolateral adrenalectomy, a 47-year-old woman stopped taking corticosteroid replacement therapy in the first 15 days of therapy. She was admitted to the Department of Internal Medicine because of hypertension, severe hypercalcemia, uncompensated metabolic alkalosis and clinical sym
- PMID 18299699
- A case report of uncompensated alkalosis induced by daily plasmapheresis in a patient with thrombotic thrombocytopenic purpura.
- Nagai Y1, Itabashi M, Mizutani M, Ogawa T, Yumura W, Tsuchiya K, Nitta K.Author information 1Department of Medicine IV, Tokyo Women's Medical University, Tokyo, Japan.AbstractPlasmapheresis (PP) is widely known as the standard therapy for thrombotic thrombocytopenic purpura (TTP). Citrate is used as an anticoagulant in fresh frozen plasma, and the large amount of citrate infused during PP induces metabolic alkalosis. A 29-year-old woman was diagnosed with TTP associated with systemic lupus erythematosus, and was treated by daily PP in addition to a steroid, an immunosuppressant, vincristine, and cyclophosphamide. Uncompensated alkalosis caused by a combination of metabolic and respiratory alkalosis developed after artificial ventilation was discontinued. Her metabolic status improved after controlling her respiratory status and the activity of the TTP. Metabolic alkalosis is a common complication in TTP patients treated by frequent PP, but several factors that affect metabolic status may aggravate the alkalosis and induce uncompensated alkalosis.
- Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy.Ther Apher Dial.2008 Feb;12(1):86-90. doi: 10.1111/j.1744-9987.2007.00547.x.
- Plasmapheresis (PP) is widely known as the standard therapy for thrombotic thrombocytopenic purpura (TTP). Citrate is used as an anticoagulant in fresh frozen plasma, and the large amount of citrate infused during PP induces metabolic alkalosis. A 29-year-old woman was diagnosed with TTP associated
- PMID 18257819
Japanese Journal
- A case report of uncompensated alkalosis induced by daily plasmapheresis in a patient with thrombotic thrombocytopenic purpura
Related Links
- uncompensated alkalosis un·com·pen·sat·ed alkalosis (ŭn-kŏm'pən-sā'tĭd) n. A rise in the alkalinity of body fluids without any compensating physiological action to lower the pH. The American Heritage® Stedman's Medical ...
- Menu Dictionary YD Original Websters AHD Ologies Business Computer Culture Images/Pictures Invest Law Medical Phrases/Idioms Science See in a sentence Thesaurus Quotes Teaching & Learning Education ESL Grammar
★リンクテーブル★
[★]
- 英
- uncompensated alkalosis
- 関
- アルカローシス