- 非結合性の、非結合の
WordNet
- not secured within a cover; "an unbound book"
- not held in chemical or physical combination
- not restrained or tied down by bonds
PrepTutorEJDIC
- unbind の過去・過去分詞 / 結ばれていない / (本などが)とじてない,製本されていない
- 果てしない,無限の(boundless)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/04/27 15:45:18」(JST)
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- 1. 破傷風 tetanus
- 2. 正期産児および後期早産児における非抱合型高ビリルビン血症の評価 evaluation of unconjugated hyperbilirubinemia in term and late preterm infants
- 3. 非プラチナ製剤ベースの癌化学療法の神経学的合併症の概要 overview of neurologic complications of non platinum cancer chemotherapy
- 4. ステロイド用量の決定因子 determinants of glucocorticoid dosing
- 5. 持続的腎代替療法中の薬物除去 drug removal during continuous renal replacement therapy
English Journal
- Structural basis for the rational design of new anti-Brucella agents: The crystal structure of the C366S mutant of l-histidinol dehydrogenase from Brucella suis.
- D'ambrosio K1, Lopez M2, Dathan NA1, Ouahrani-Bettache S3, Köhler S3, Ascione G1, Monti SM4, Winum JY5, De Simone G6.Author information 1Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134 Napoli, Italy.2Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM1-UM2, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France; Centre d'Etudes d'Agents Pathogènes et Biotechnologies pour la Santé (CPBS), UMR 5236 CNRS-UM1-UM2, 1919 Route de Mende, 34293 Montpellier, France.3Centre d'Etudes d'Agents Pathogènes et Biotechnologies pour la Santé (CPBS), UMR 5236 CNRS-UM1-UM2, 1919 Route de Mende, 34293 Montpellier, France.4Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134 Napoli, Italy. Electronic address: marmonti@unina.it.5Institut des Biomolécules Max Mousseron (IBMM), UMR 5247 CNRS-UM1-UM2, Bâtiment de Recherche Max Mousseron, Ecole Nationale Supérieure de Chimie de Montpellier, 8 rue de l'Ecole Normale, 34296 Montpellier Cedex, France.6Istituto di Biostrutture e Bioimmagini-CNR, Via Mezzocannone 16, 80134 Napoli, Italy. Electronic address: gdesimon@unina.it.Abstractl-Histidinol dehydrogenase from Brucella suis (BsHDH) is an enzyme involved in the histidine biosynthesis pathway which is absent in mammals, thus representing a very interesting target for the development of anti-Brucella agents. In this paper we report the crystallographic structure of a mutated form of BsHDH both in its unbound form and in complex with a nanomolar inhibitor. These studies provide the first structural background for the rational design of potent HDH inhibitors, thus offering new hints for clinical applications.
- Biochimie.Biochimie.2014 Feb;97:114-20. doi: 10.1016/j.biochi.2013.09.028. Epub 2013 Oct 17.
- l-Histidinol dehydrogenase from Brucella suis (BsHDH) is an enzyme involved in the histidine biosynthesis pathway which is absent in mammals, thus representing a very interesting target for the development of anti-Brucella agents. In this paper we report the crystallographic structure of a mutated f
- PMID 24140957
- Cluster of differentiation antibody microarrays on plasma immersion ion implanted polycarbonate.
- Kosobrodova E1, Mohamed A2, Su Y3, Kondyurin A4, Dos Remedios CG2, McKenzie DR4, Bilek MM4.Author information 1Department of Applied Plasma and Physics, School of Physics, University of Sydney, Sydney, 2006, Australia. Electronic address: elenak@physics.usyd.edu.au.2Muscle Research Unit, Discipline of Anatomy and Histology, Bosch Institute, University of Sydney, Sydney, 2006, Australia.3Australian Center of Microscopy and Analysis, University of Sydney, Sydney, 2006, Australia.4Department of Applied Plasma and Physics, School of Physics, University of Sydney, Sydney, 2006, Australia.AbstractPlasma immersion ion implantation (PIII) modifies the surface properties of polymers, enabling them to covalently immobilize proteins without using linker chemistry. We describe the use of PIII treated polycarbonate (PC) slides as a novel platform for producing microarrays of cluster of differentiation (CD) antibodies. We compare their performance to identical antibody microarrays printed on nitrocellulose-coated glass slides that are currently the industry standard. Populations of leukocytes are applied to the CD microarrays and unbound cells are removed revealing patterns of differentially immobilized cells that are detected in a simple label-free approach by scanning the slides with visible light. Intra-slide and inter-slide reproducibility, densities of bound cells, and limits of detection were determined. Compared to the nitrocellulose-coated glass slides, PIII treated PC slides have a lower background noise, better sensitivity, and comparable or better reproducibility. They require three-fold lower antibody concentrations to yield equivalent signal strength, resulting in significant reductions in production cost. The improved transparency of PIII treated PC in the near-UV and visible wavelengths combined with superior immobilization of biomolecules makes them an attractive platform for a wide range of microarray applications.
- Materials science & engineering. C, Materials for biological applications.Mater Sci Eng C Mater Biol Appl.2014 Feb 1;35:434-40. doi: 10.1016/j.msec.2013.11.034. Epub 2013 Dec 4.
- Plasma immersion ion implantation (PIII) modifies the surface properties of polymers, enabling them to covalently immobilize proteins without using linker chemistry. We describe the use of PIII treated polycarbonate (PC) slides as a novel platform for producing microarrays of cluster of differentiat
- PMID 24411398
- Direct determination of free bilirubin in serum at sub-nanomolar levels.
- Martelanc M1, Ziberna L2, Passamonti S2, Franko M3.Author information 1University of Nova Gorica, Laboratory for Environmental Research, Vipavska 13, POB 301, SI-5001 Nova Gorica, Slovenia.2University of Trieste, Department of Life Science, via L. Giorgeri 1, 34127 Trieste, Italy.3University of Nova Gorica, Laboratory for Environmental Research, Vipavska 13, POB 301, SI-5001 Nova Gorica, Slovenia. Electronic address: mladen.franko@ung.si.AbstractDirect analysis of free bilirubin in human and animal blood serum samples is reported for the first time. A state-of-the-art system comprised of newly developed high-performance liquid chromatography (HPLC) on reverse-phase (RP) C18 support coupled with thermal lens spectrometric detection (TLS), based on excitation at λ=457.9nm by an argon laser was used for this purpose. This HPLC-TLS method enabled a baseline separation of all three structural isomers of bilirubin (XIII-α, IX-α and III-α) and the respective degradation products in isocratic mode in fewer than 7min. The method excels in ultra-high sensitivity with limit of detection (LOD) and limit of quantitation (LOQ) of 90pM and 250pM, respectively. Moreover, this method also affords high precision and accuracy, with correlation coefficients R(2)>0.997 over a broad linear range (0.250-150nM) and R(2)=0.9998 in a concentration range of clinical interest (0.500-25nM). The method's boosted sensitivity enabled to streamline sample preparation to just one serum ultrafiltration step, which made qualitative evaluation of sample preparation possible for the first time. The performance of the HPLC-TLS method was assessed to have 20-fold enhanced sensitivity when compared to a comparable method incorporating HPLC coupled with diode array detector (DAD), which is also a novel method by itself, and could be applied for free bilirubin determination in patients with elevated bilirubin levels.
- Analytica chimica acta.Anal Chim Acta.2014 Jan 27;809:174-82. doi: 10.1016/j.aca.2013.11.041. Epub 2013 Dec 1.
- Direct analysis of free bilirubin in human and animal blood serum samples is reported for the first time. A state-of-the-art system comprised of newly developed high-performance liquid chromatography (HPLC) on reverse-phase (RP) C18 support coupled with thermal lens spectrometric detection (TLS), ba
- PMID 24418149
- Effect of experimentally induced hypovolemia on ertapenem tissue distribution using microdialysis in rats.
- de Castro WV, Marchand S, Lamarche I, Couet W.Author information Universidade Federal de São João del-Rei, Brazil; Inserm U-1070, Poitiers, France.AbstractHypovolemia is a common event in critical care patients that may affect drug distribution and elimination. In order to better understand this issue the effect of hypovolemia on the plasma protein binding and tissue distribution of ertapenem was investigated in rats using microdialysis. Microdialysis probes were inserted into the jugular vein and hind leg muscle. Ertapenem recoveries in muscle and blood were determined in each rat by retrodialysis by drug before drug administration. Hypovolemia was induced in 6 rats by removing 40% of the initial blood volume over 30 min. Ertapenem was infused intravenously at a dose of 40 mg kg(-1) over 30 min, and microdialysis samples were collected for 310 min. The unbound concentration profiles in muscle and blood were virtually superimposed in both groups except at early time points. The ratios of the area under the concentration-time curve (AUC) for tissue to the AUC for blood were 0.7±0.2 and 0.8±0.2 for control and hypovolemic rats, respectively. Hypovolemia induced a 40% decrease in the clearance of ertapenem, with no statistically significant alteration of its volume of distribution. This study showed that ertapenem elimination was altered in hypovolemic rats, probably due to decreased renal blood flow, but its distribution characteristics were not. Unbound concentrations of ertapenem in blood and muscle were always virtually identical.
- European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.Eur J Pharm Sci.2014 Jan 23;51:45-50. doi: 10.1016/j.ejps.2013.08.017. Epub 2013 Aug 30.
- Hypovolemia is a common event in critical care patients that may affect drug distribution and elimination. In order to better understand this issue the effect of hypovolemia on the plasma protein binding and tissue distribution of ertapenem was investigated in rats using microdialysis. Microdialysis
- PMID 23999032
Japanese Journal
- Virtual-state character of the Be-9 1/2(+) state in the Be-9(γ,n)Be-8 reaction
- Physical review C 92(1), 14322, 2015-07-27
- NAID 120005651853
- PK解析の基礎—Phase Iを中心に—
- 計量生物学 36(Special_Issue), S3-S18, 2015
- NAID 130005097962
- 麻薬性鎮痛薬の中枢効果を制御する血液脳関門輸送機構
- 薬学雑誌. 乙号 135(5), 697-702, 2015
- NAID 130005066918
- A Case of Valproate Overdose Complicated by Severe Hyperammonemia that was Ameliorated with Time Concomitant with Decline in Serum Valproate Concentration
- 臨床薬理 46(2), 77-79, 2015
- NAID 130005064873
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★リンクテーブル★
| リンク元 | 「nonbonded」「nonbonding」「非結合」「非結合性」 |
「nonbonded」
- 非結合性の、非結合の
「nonbonding」
- 非結合性の、非結合の