WordNet
- territory over which rule or control is exercised; "his domain extended into Europe"; "he made it the law of the land" (同)demesne, land
- (mathematics) the set of values of the independent variable for which a function is defined (同)domain of a function
- an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
- an amino acid found in most proteins; a precursor of several hormones
- the basic unit of money in Papua New Guinea
PrepTutorEJDIC
- (国の)領地,領土;(個人の)所有地 / (関心・活動などの)範囲,分野 / (個人・一族の)所有地 / (数学で)変域(関数の独立変数がとる値の集合)
UpToDate Contents
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- 1. 慢性骨髄性白血病の治療の概要 overview of the treatment of chronic myeloid leukemia
- 2. 血管新生阻害剤の概要 overview of angiogenesis inhibitors
- 3. 未分化リンパ腫キナーゼ（ALK）融合癌遺伝子陽性非小細胞肺癌 anaplastic lymphoma kinase alk fusion oncogene positive non small cell lung cancer
- 4. 慢性骨髄性白血病に対するチロシンキナーゼ阻害剤の臨床使用 clinical use of tyrosine kinase inhibitors for chronic myeloid leukemia
- 5. 上皮成長因子受容体変異を有する進行非小細胞肺癌に対する全身療法 systemic therapy for advanced non small cell lung cancer with an activating mutation in the epidermal growth factor receptor
English Journal
- c-Abl links APP-BACE1 interaction promoting APP amyloidogenic processing in Niemann-Pick type C disease.
- Yáñez MJ1, Belbin O2, Estrada LD3, Leal N3, Contreras PS1, Lleó A2, Burgos PV4, Zanlungo S5, Alvarez AR6.
- Biochimica et biophysica acta.Biochim Biophys Acta.2016 Nov;1862(11):2158-2167. doi: 10.1016/j.bbadis.2016.08.016. Epub 2016 Aug 23.
- BACKGROUND: Niemann-Pick type C (NPC) disease is characterized by lysosomal accumulation of cholesterol. Interestingly, NPC patients' brains also show increased levels of amyloid-β (Aβ) peptide, a key protein in Alzheimer's disease pathogenesis. We previously reported that the c-Abl tyrosine kinas
- PMID 27565738
- Role of Herpes simplex virus 1 VP11/12 tyrosine-based binding motifs for Src family kinases, p85, Grb2 and Shc in activation of the phosphoinositide 3-kinase-Akt pathway.
- Strunk U1, Ramos DG1, Saffran HA1, Smiley JR2.
- Virology.Virology.2016 Nov;498:31-5. doi: 10.1016/j.virol.2016.08.007. Epub 2016 Aug 17.
- The abundant HSV-1 tegument protein VP11/12 encoded by gene UL46 is essential for induction of the PI3K/Akt-signaling pathway during infection. VP11/12 utilizes tyrosine-based motifs within its C-terminal region to bind the SH2 domains of Src family kinases, the p85 subunit of PI3 Kinase and Grb2, a
- PMID 27543756
- Intrinsic HER4/4ICD transcriptional activation domains are required for STAT5A activated gene expression.
- Han W1, Sfondouris ME1, Semmes EC1, Meyer AM1, Jones FE2.
- Gene.Gene.2016 Oct 30;592(1):221-6. doi: 10.1016/j.gene.2016.07.071. Epub 2016 Aug 5.
- The epidermal growth factor receptor family member HER4 undergoes proteolytic processing at the cell surface to release the HER4 intracellular domain (4ICD) nuclear protein. Interestingly, 4ICD directly interacts with STAT5 and functions as an obligate STAT5 nuclear chaperone. Once in the nucleus 4I
- PMID 27502417
Japanese Journal
- Serum Amyloid A Induces NLRP-3-Mediated IL-1β Secretion in Neutrophils
- Migita Kiyoshi,Izumi Yasumori,Jiuchi Yuka,Kozuru Hideko,Kawahara Chieko,Nakamura Minoru,Nakamura Tadashi,Agematsu Kazunaga,Masumoto Junya,Yasunami Michio,Kawakami Atsushi,Eguchi Katsumi
- PLoS ONE 9(5), e96703, 2014-05-20
- … IL-1β or Nod-like receptor family, pyrin domain containing 3 (NLRP3) mRNA expressions were analyzed by real-time PCR or reverse transcription-PCR (RT-PCR) method. … Analysis of intracellular signaling revealed that SAA stimulation activated the tyrosine kinase Syk and mitogen-activated protein kinase (MAPK). …
- NAID 120005447070
- Molecular analysis of the BCR-ABL1 kinase domain in chronic-phase chronic myelogenous leukemia treated with tyrosine kinase inhibitors in practice: Study by the Nagasaki CML Study Group
- Itonaga Hidehiro,Tsushima Hideki,Imanishi Daisuke,Hata Tomoko,Doi Yuko,Mori Sayaka,Sasaki Daisuke,Hasegawa Hiroo,Matsuo Emi,Nakashima Jun,Kato Takeharu,Horai Makiko,Taguchi Masataka,Matsuo Masatoshi,Taniguchi Hiroaki,Makiyama Junnya,Sato Shinya,Horio Kensuke,Ando Koji,Moriwaki Yuji,Sawayama Yasushi,Ogawa Daisuke,Yamasaki Reishi,Takasaki Yumi,Imaizumi Yoshitaka,Taguchi Jun,Kawaguchi Yasuhisa,Yoshida Shinichiro,Joh Tatsuro,Moriuchi Yukiyoshi,Nonaka Hiroaki,Soda Hisashi,Fukushima Takuya,Nagai Kazuhiro,Kamihira Shimeru,Tomonaga Masao,Yanagihara Katsunori,Miyazaki Yasushi
- Leukemia Research 38(1), 76-83, 2014-01
- … We examined 92 patients after 12 months of tyrosine kinase inhibitor (TKI) treatment in Nagasaki Prefecture, Japan. … Univariate analysis revealed that significant factors associated with not attaining a major molecular response (MMR) were the presence of the minor BCR-ABL1 fusion gene, a low daily dose of TKI, and the emergence of BCR-ABL1 kinase domain mutations conferring resistance to imatinib. …
- NAID 120005367584
- Identification of a Novel SHP-2 Protein Tyrosine Phosphatase Inhibitor
- Ju Anna,Seo Huiyun,Kim Heemun,Park Byoung Chul,Park Sung Goo,Kim Jeong Hoon,Choi Hyung-Kyoon,Min Kyung Hoon,Cho Sayeon
- Bulletin of the Chemical Society of Japan 87(3), 420-424, 2014
- … The Src homology 2 (SH2) domain-containing phosphatase 2 (SHP-2) is a nonreceptor protein tyrosine phosphatase (PTP) involved in extracellular-regulated kinase (ERK) activation. …
- NAID 130004153283
Related Links
- InterPro provides functional analysis of proteins by classifying them into families and predicting domains and important sites. We combine protein signatures from a number of member databases into a single searchable resource ...
- Crystal Structures In this paper we discuss five distinct conformations of the kinase domain of Abl, based on four new crystal structures as well as the previously published structure of the Abl:imatinib complex ( Table 1).
Related Pictures
★リンクテーブル★
| リンク元 | 「チロシンキナーゼ領域」「チロシンキナーゼドメイン」 |
| 関連記事 | 「domain」「kinase」「kinase domain」「domains」 |
「チロシンキナーゼ領域」
「チロシンキナーゼドメイン」
「domain」
- n.
「kinase」
[★] キナーゼ カイネース リン酸化酵素 phosphoenzyme phosphotransferase
「kinase domain」
「domains」
- 関
- See also specific type