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1. チロシン代謝障害 disorders of tyrosine metabolism
2. 慢性骨髄性白血病の治療の概要 overview of the treatment of chronic myeloid leukemia
3. インスリン受容体の構造および機能 structure and function of the insulin receptor
4. 進行消化管間質腫瘍に対するチロシンキナーゼ阻害剤療法 tyrosine kinase inhibitor therapy for advanced gastrointestinal stromal tumors
5. 慢性骨髄性白血病に対するチロシンキナーゼ阻害剤の臨床使用 clinical use of tyrosine kinase inhibitors for chronic myeloid leukemia

TGFβ responsive tyrosine phosphatase promotes rheumatoid synovial fibroblast invasiveness.

Stanford SM1, Aleman Muench GR1, Bartok B2, Sacchetti C3, Kiosses WB4, Sharma J1, Maestre MF1, Bottini M5, Mustelin T6, Boyle DL2, Firestein GS2, Bottini N1.
Annals of the rheumatic diseases.Ann Rheum Dis.2016 Jan;75(1):295-302. doi: 10.1136/annrheumdis-2014-205790. Epub 2014 Nov 6.
OBJECTIVE: In rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS) that line joint synovial membranes aggressively invade the extracellular matrix, destroying cartilage and bone. As signal transduction in FLS is mediated through multiple pathways involving protein tyrosine phosphorylation,
PMID 25378349

High-Throughput Screening of Substrate Specificity for Protein Tyrosine Phosphatases (PTPs) on Phosphopeptide Microarrays.

Gao L1,2, Lee SS1, Chen J3, Sun H4, Zhao Y3, Chai Z3, Hu Y5.
Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2016;1368:181-96. doi: 10.1007/978-1-4939-3136-1_13.
Phosphatases are a family of enzymes responsible for the dephosphorylation of biomolecules. Phosphatases play essential roles in cell cycle regulation, signal transduction, and cellular communication. In recent years, one type of phosphatases, protein tyrosine phosphatases (PTPs), emerges as importa
PMID 26614076

Angiotensin II down-regulates nephrin-Akt signaling and induces podocyte injury: roleof c-Abl.

Yang Q1, Ma Y1, Liu Y1, Liang W1, Chen X1, Ren Z1, Wang H1, Singhal PC2, Ding G3.
Molecular biology of the cell.Mol Biol Cell.2016 Jan 1;27(1):197-208. doi: 10.1091/mbc.E15-04-0223. Epub 2015 Oct 28.
Recent studies have shown that nephrin plays a vital role in angiotensin II (Ang II)-induced podocyte injury and thus contributes to the onset of proteinuria and the progression of renal diseases, but its specific mechanism remains unclear. c-Abl is an SH2/SH3 domain-containing nonreceptor tyrosine
PMID 26510503

Large-scale determination of absolute phosphorylation stoichiometries in human cells by motif-targeting quantitative proteomics.

Tsai Chia-Feng,Wang Yi-Ting,Yen Hsin-Yung,Tsou Chih-Chiang,Ku Wei-Chi,Lin Pei-Yi,Chen Hsuan-Yu,Nesvizhskii Alexey I,Ishihama Yasushi,Chen Yu-Ju
Nature communications 6, 2015-03-27
… Proteome-wide phosphorylation stoichiometry can be obtained by a simple phosphoproteomic workflow integrating dephosphorylation and isotope tagging with enzymatic kinase reaction. … We measure the phosphorylation stoichiometry of >1,000 phosphorylation sites including 366 low-abundance tyrosine phosphorylation sites, with high reproducibility and using small sample sizes. …
NAID 120005625634

T-cell protein tyrosine phosphatase (TCPTP) regulates phosphorylation of Txk, a tyrosine kinase of the Tec family

Maruyama Tatsuya,Shimizu Jun,Suzuki Noboru
Inflammation and Regeneration 34(5), 240-246, 2014
… Phosphorylation and dephosphorylation of intracellular enzymes, such as the T-cell-specific Tec family protein kinase Txk, are critically involved in the regulation of a number of cellular functions. … Here, we investigate the role of TCPTP in the regulation of Txk phosphorylation/dephosphorylation in Txk-transfected Cos7 and Jurkat cells.<BR>Nuclear-type TCPTP (TC45) was present in both the nuclear and cytoplasmic compartments of Cos7 cells transfected with TC45. …
NAID 130004943871

鮫島正純
PLANT MORPHOLOGY 24(1), 65-71, 2012
細胞性粘菌<I>Dictyostelium discoideum</I>においては，胞子の核と細胞質の両方に出現する新奇アクチンロッドが，胞子の休眠の維持と生存に関わっている．ロッドは，六角形に配列した直径約13nmのアクチン小管から構成されており，さらに，S-アデノシル-L-ホモシステインヒドロラーゼを構成成分としている．アクチンロッドに加えて，胞子の細胞質にはG-アクチ …
NAID 130004726672