WordNet

a chemical process that combines several monomers to form a polymer or polymeric compound (同)polymerisation

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1. 肝疾患を有する患者における化学療法による肝毒性および用量調整 chemotherapy hepatotoxicity and dose modification in patients with liver disease
2. 駆虫薬療法 anthelminthic therapies
3. 女性の転移性乳癌に対する全身療法：化学療法 systemic treatment of metastatic breast cancer in women chemotherapy
4. 非プラチナ製剤ベースの癌化学療法の神経学的合併症の概要 overview of neurologic complications of non platinum cancer chemotherapy
5. アントラサイクリン系以外の癌化学療法剤の心毒性 cardiotoxicity of nonanthracycline cancer chemotherapy agents

Taxol-induced growth arrest and apoptosis is associated with the upregulation of the Cdk inhibitor, p21WAF1/CIP1, in human breast cancer cells.

Choi YH, Yoo YH.SourceDepartment of Biochemistry, Dongeui University College of Oriental Medicine, Busan 614-052, Republic of Korea.
Oncology reports.Oncol Rep.2012 Dec;28(6):2163-9. doi: 10.3892/or.2012.2060. Epub 2012 Sep 26.
The anticancer agent, taxol, stabilizes tubulin polymerization, resulting in arrest at the G2/M phase of the cell cycle and apoptotic cell death. However, the molecular mechanism of this growth inhibition and apoptosis is poorly understood. In this study, we used
PMID 23023313

Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.

Liu Y, Wei D, Zhao Y, Cheng W, Lu Y, Ma Y, Li X, Han C, Wei Y, Cao H, Zhao C.SourceSchool of Pharmacy, Lanzhou University, Lanzhou 730000, China.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2012 Nov 1;20(21):6285-95. doi: 10.1016/j.bmc.2012.09.009. Epub 2012 Sep 13.
A series of eight novel podophyllotoxin derivatives were designed, synthesized and evaluated for biological activities. The antiproliferative activities were tested against a panel of human cancer cell lines (K562, SGC, Hela and HepG) and the inhibition of tubulin polymerization was also evaluated.
PMID 23022053

Efficient Drug Delivery of Paclitaxel Glycoside: A Novel Solubility Gradient Encapsulation into Liposomes Coupled with Immunoliposomes Preparation

Shigehiro Tsukasa,Kasai Tomonari,Murakami Masaharu,Sekhar Sreeja C.,Tominaga Yuki,Okada Masashi,Kudoh Takayuki,Mizutani Akifumi,Murakami Hiroshi,Salomon David S.,Mikuni Katsuhiko,Mandai Tadakatsu,Hamada Hiroki,Seno Masaharu
PLoS ONE 9(9), 2014-09-29
… We found that a more hydrophilic paclitaxel molecule, 7-glucosyloxyacetylpaclitaxel, retained tubulin polymerization stabilization activity. …
NAID 120005477121

Miyashital Tomoyuki,Takami Akiko,Sugimoto Yui,Sakai Ayumi,Takagi Ryosuke
Memoirs of the Faculty of Biology-Oriented Science and Technology of Kinki University 31, 1-8, 2013-03
… [Abstract] We have isolated a full-length Pinctada fucata a-tubulin gene that is one of the genes obtained in the process of selecting the BMP (Bone Morphogenetic Protein) type II receptor gene. … The 1678 base pair (bp) length of a-tubulin cDNA encodes 451 amino acids and the calculated mass is 42 kDa. … The gene belongs to one of the Pinctada fucata a-tubulin family and was designated a-tubulin 2. …
NAID 120005260074