trypanosomal

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1. アフリカ・トリパノソーマ症の疫学、病因、および予防 epidemiology pathogenesis and prevention of african trypanosomiasis
2. アフリカ・トリパノソーマ症の臨床症状、診断、および治療 clinical manifestations diagnosis and treatment of african trypanosomiasis
3. 抗原虫治療 antiprotozoal therapies

An in vitro iron superoxide dismutase inhibitor decreases the parasitemia levels of Trypanosoma cruzi in BALB/c mouse model during acute phase.

Olmo F1, Urbanová K1, Rosales MJ1, Martín-Escolano R1, Sánchez-Moreno M1, Marín C1.
International journal for parasitology. Drugs and drug resistance.Int J Parasitol Drugs Drug Resist.2015 Jun 20;5(3):110-6. doi: 10.1016/j.ijpddr.2015.05.002. eCollection 2015.
In order to identify new compounds to treat Chagas disease during the acute phase with higher activity and lower toxicity than the reference drug benznidazole (Bz), two hydroxyphthalazine derivative compounds were prepared and their trypanocidal effects against Trypanosoma cruzi were evaluated by li
PMID 26236582

Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites.

Engel JA1, Jones AJ1, Avery VM1, Sumanadasa SD1, Ng SS1, Fairlie DP2, Adams TS1, Andrews KT1.
International journal for parasitology. Drugs and drug resistance.Int J Parasitol Drugs Drug Resist.2015 Jun 20;5(3):117-26. doi: 10.1016/j.ijpddr.2015.05.004. eCollection 2015.
Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs) to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are involved in regulating chromatin structure and gene expression as well as other important cellular processes. HDACs ar
PMID 26199860

Jirků M1, Votýpka J2, Petrželková KJ3, Jirků-Pomajbíková K4, Kriegová E4, Vodička R5, Lankester F6, Leendertz SA7, Wittig RM8, Boesch C9, Modrý D10, Ayala FJ11, Leendertz FH12, Lukeš J13.
International journal for parasitology. Parasites and wildlife.Int J Parasitol Parasites Wildl.2015 Jun 16;4(3):277-82. doi: 10.1016/j.ijppaw.2015.05.001. eCollection 2015.
Although wild chimpanzees and other African great apes live in regions endemic for African sleeping sickness, very little is known about their trypanosome infections, mainly due to major difficulties in obtaining their blood samples. In present work, we established a diagnostic ITS1-based PCR assay
PMID 26110113

志波智生,高橋元,原田繁春 [他],斎本博之,城戸康年,稲岡ダニエル健,北潔
日本結晶学会誌 55(4), 254-259, 2013-08-31
… We determined the first crystal structures of the trypanosomal alternative oxidase in the absence and presence of ascofuranone and its derivatives, which are drug candidates for African trypanosomiasis. …
NAID 10031194726

青木孝
順天堂医学 57(3), 203-215, 2011
1970年代から2010年までに順天堂で私達が行ってきた研究について概括する. 当初, カイチュウと宿主の比較生化学的研究からはじめ, 核酸塩基ピリミジンde novo生合成経路の存在をパラサイトではじめて報告した. 同経路の第1酵素CPS IIの律速・調節機能は宿主と異なる特徴を示した. また, 腫瘍とパラサイトのピリミジン生合成, CPS IIについて生化学的類似および相違を異なる切り口からみ …
NAID 130004716510