WordNet

a radioactive isotope of hydrogen; atoms of tritium have three times the mass of ordinary hydrogen atoms

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Elmore CS1, Bragg RA2.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2015 Jan 15;25(2):167-71. doi: 10.1016/j.bmcl.2014.11.051. Epub 2014 Nov 26.
As Medicinal Chemists are responsible for the synthesis and optimization of compounds, they often provide intermediates for use by isotope chemistry. Nevertheless, there is generally an incomplete understanding of the critical factors involved in the labeling of compounds. The remit of an Isotope Ch
PMID 25499878

Iridium-catalyzed H/D exchange: ligand complexes with improved efficiency and scope.

Parmentier M1, Hartung T, Pfaltz A, Muri D.
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2014 Sep 1;20(36):11496-504. doi: 10.1002/chem.201402078. Epub 2014 Jul 10.
Hydrogen isotope exchange (HIE) is one of the most attractive tools for the introduction of deuterium or tritium to an organic compound. Herein, iridium complexes with N,P-ligands, highly active catalysts for asymmetric double bond reductions, have been tested for their HIE capabilities. Electron-ri
PMID 25043104

Gene expression levels of matrix metalloproteinases in human atherosclerotic plaques and evaluation of radiolabeled inhibitors as imaging agents for plaque vulnerability.

Müller A1, Krämer SD2, Meletta R2, Beck K2, Selivanova SV2, Rancic Z3, Kaufmann PA4, Vos B5, Meding J5, Stellfeld T5, Heinrich TK5, Bauser M5, Hütter J5, Dinkelborg LM5, Schibli R2, Ametamey SM2.
Nuclear medicine and biology.Nucl Med Biol.2014 Aug;41(7):562-9. doi: 10.1016/j.nucmedbio.2014.04.085. Epub 2014 Apr 21.
INTRODUCTION: Atherosclerotic plaque rupture is the primary cause for myocardial infarction and stroke. During plaque progression macrophages and mast cells secrete matrix-degrading proteolytic enzymes, such as matrix metalloproteinases (MMPs). We studied levels of MMPs and tissue inhibitor of metal
PMID 24853402

Muscarinic Receptor Binding of the Novel Radioligand, [³H]Imidafenacin in the Human Bladder and Parotid Gland

Yoshida Akira,Kuraoka Shiori,Ito Yoshihiko [他],Okura Takashi,Deguchi Yoshiharu,Otsuka Atsushi,Ozono Seiichiro,Takeda Masayuki,Masuyama Keisuke,Araki Isao,Yamada Shizuo
Journal of Pharmacological Sciences 124(1), 40-46, 2014
… The aim of the current study was to demonstrate highly specific and direct binding activity of tritium ([3H])-labeled imidafenacin for labeling muscarinic receptors in human bladder and parotid gland. … [3H]Imidafenacin may also be a useful radioligand for labeling the M3 subtype of muscarinic receptors with higher selectivity than other radioligands. …
NAID 130003382631

門口泰也,佐治木弘尚
有機合成化学協会誌 70(7), 711-721, 2012-07-01
… Palladium on charcoal (Pd/C), which has been used as a common hydrogenation catalyst, is finding various applications including cross-coupling and deuterium (tritium) labeling reactions. …
NAID 10030835279

Fusarielin A as an Anti-angiogenic and Anti-proliferative Agent : Basic Biological Characterization

Fujimoto Haruka,Aoyama Hiroshi,Noguchi-Yachide Tomomi [他],HASHIMOTO Yuichi,KOBAYASHI Hisayoshi
Chemical & pharmaceutical bulletin 56(3), 298-304, 2008-03-01
… A ^3H-labeled derivative and a fluorescent affinity-labeling agent were prepared and used to examine the cellular distribution and biological behavior of fusarielin A. …
NAID 110006622632