トリホスファターゼ、三リン酸分解酵素
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/09 18:13:10」(JST)
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| triphosphatase |
| Identifiers |
| EC number |
3.6.1.25 |
| CAS number |
62213-21-2 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
|
In enzymology, a triphosphatase (EC 3.6.1.25) is an enzyme that catalyzes the chemical reaction
- triphosphate + H2O diphosphate + phosphate
Thus, the two substrates of this enzyme are triphosphate and H2O, whereas its two products are diphosphate and phosphate.
This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is triphosphate phosphohydrolase. This enzyme is also called inorganic triphosphatase.
References
- Kulaev IS, Konoshenko GI and Umnov AM (Moscow). "Localization of polyphosphatase hydolyzing polyphosphates to orthophosphate in subcellular structures of Neurospora crassa". B. Biochemistry: 190–194.
- Umnov AM, Egorov SN, Mansurova SE and Kulaev IS (Moscow). "A comparative characterisation of the polyphosphatases of Neurospora crassa and some other organisms". B. Biochemistry: 309–312.
UpToDate Contents
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English Journal
- Gestational doxorubicin alters fetal thyroid-brain axis.
- Ahmed RG, Incerpi S.SourceDivision of Anatomy and Embryology, Zoology Department, Faculty of Science, Beni-Suef University, Egypt. Electronic address: ragabb900@yahoo.com.
- International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.Int J Dev Neurosci.2013 Apr;31(2):96-104. doi: 10.1016/j.ijdevneu.2012.11.005. Epub 2012 Nov 23.
- Administration of chemotherapy during pregnancy may represent a big risk factor for the developing brain, therefore we studied whether the transplacental transport of doxorubicin (DOX) may affect the development of neuroendocrine system. DOX (25mg/kg; 3 times interaperitoneally/week) was given to pr
- PMID 23183240
- Model incorporating the ITPA genotype identifies patients at high risk of anemia and treatment failure with pegylated-interferon plus ribavirin therapy for chronic hepatitis C.
- Kurosaki M, Tanaka Y, Nishida N, Sakamoto N, Enomoto N, Matsuura K, Asahina Y, Nakagawa M, Watanabe M, Sakamoto M, Maekawa S, Tokunaga K, Mizokami M, Izumi N.SourceDepartment of Gastroenterology and Hepatology, Musashino Red Cross Hospital, Tokyo, Japan.
- Journal of medical virology.J Med Virol.2013 Mar;85(3):449-58. doi: 10.1002/jmv.23497. Epub 2013 Jan 7.
- This study aimed to develop a model for predicting anemia using the inosine triphosphatase (ITPA) genotype and to evaluate its relationship with treatment outcome. Patients with genotype 1b chronic hepatitis C (n = 446) treated with peg-interferon alpha and ribavirin (RBV) for 48 weeks were geno
- PMID 23297176
- Kinesin family member 14 is a candidate prognostic marker for outcome of glioma patients.
- Wang Q, Wang L, Li D, Deng J, Zhao Z, He S, Zhang Y, Tu Y.SourceDepartment of Experimental Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an City 710032, China.
- Cancer epidemiology.Cancer Epidemiol.2013 Feb;37(1):79-84. doi: 10.1016/j.canep.2012.08.011. Epub 2012 Sep 21.
- Background & aim: Human kinesin superfamily proteins (KIFs) are a conserved class of microtubule-dependent molecular motor proteins with adenosine triphosphatase activity and motion characteristics. As a member of KIFs, KIF14 plays an important role in the regulation of cell cycle and mitotic pr
- PMID 22999822
Japanese Journal
- ITPA gene variant protects against anemia induced by pegylated interferon-α and ribavirin therapy for Japanese patients with chronic hepatitis C
- SAKAMOTO Naoya,TANAKA Yasuhito,NAKAGAWA Mina,YATSUHASHI Hiroshi,NISHIGUCHI Shuhei,ENOMOTO Nobuyuki,AZUMA Seishin,NISHIMURA SAKURAI Yuki,KAKINUMA Sei,NISHIDA Nao,TOKUNAGA Katsushi,HONDA Masao,ITO Kiyoaki,MIZOKAMI Masashi,WATANABE Mamoru
- Hepatology research : the official journal of the Japan Society of Hepatology 40(11), 1063-1071, 2010-11-01
- NAID 10027821470
- Fluorescence Polarization Analysis for Revealing Molecular Mechanism of Nucleotide-Dependent Phospholipid Membrane Binding of MinD Adenosine 5′-Triphosphate, Adenosine Triphosphatase
- Okuno Takashi,Ohgita Takashi,Sasa Tatsunori,Nonaka Aoi,Funasaki Noriaki,Kogure Kentaro
- Biological & Pharmaceutical Bulletin 33(10), 1746-1750, 2010
- … Membrane binding of Walker type adenosine 5′-triphosphate, adenosine triphosphatase (ATPase), MinD, is a key step in regulating the site of cell division in Escherichia coli. …
- NAID 130000402372
Related Links
- triphosphatase see adenosine triphosphatase. ... For example, a study showing significantly increased Rac1 guanosine triphosphatase activity in lung cancer cells that have undergone epithelial-mesenchymal transition suggests that ...
- 世界大百科事典 第2版 - adenosine triphosphataseの用語解説 - アデノシントリホスファターゼadenosine triphosphataseの略称。ATP(アデノシン三リン酸)をADP(アデノシン二リン酸)と無機リン酸に加水分解する酵素の総称。
★リンクテーブル★
[★]
- 英
- triphosphatase
- 関
- トリホスファターゼ
[★]
- 英
- triphosphatase
- 関
- 三リン酸分解酵素
[★]
アデノシン三リン酸分解酵素、ATPアーゼ
- 関
- adenosine triphosphatase、ATPase
[★]
ヌクレオシドトリホスファターゼ
- 関
- NTPase
[★]
アデノシントリホスファターゼ阻害薬