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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/04 03:34:36」(JST)

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Hachimycin is a polyene antibiotic.

References

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English Journal

Inhibitory effect of trichostatin on allograft rejection of corneal transplantation in rats.

Maimaitiming R1, Yang X1, Wupuer K1, Ye N1, Pan Z2.
International journal of clinical and experimental medicine.Int J Clin Exp Med.2015 Aug 15;8(8):12424-9. eCollection 2015.
BACKGROUND: Using a rat penetrating keratoplasty model, this study aims to explore the inhibitory effect of hachimycin on corneal graft rejection, to provide new basis for its clinical application.MATERIALS AND METHODS: Female adult Sprague-Dawley (SD) rats weighing between 220-250 g were used as ac
PMID 26550154

Cerylimycins [corrected] A and B: antibacterial triterpenes from the new species Tricholoma sp. AU1.

Ovenden SP1, Yu J, Bernays J, Wan SS, Christophidis LJ, Sberna G, Tait RM, Wildman HG, Lebeller D, Platel D, May TW, Meurer-Grimes BM.
Journal of natural products.J Nat Prod.2005 Mar;68(3):409-12.
To new triterpenes, trichomycins A (1) and B (2), were purified from the new species Tricholoma sp. AU1 by activity-guided fractionation following their antibacterial activity. The two compounds were found to have a hitherto unreported triterpenoid skeleton. The structures and relative stereochemist
PMID 15787446

[The cis-trans isomerization of aromatic heptaenes catalyzed by sulfur and phosphorus compounds].

Shenin IuD1, Filippova AI.
Antibiotiki i khimioterapii︠a︡ = Antibiotics and chemoterapy [sic] / Ministerstvo meditsinskoĭ i mikrobiologicheskoĭ promyshlennosti SSSR.Antibiot Khimioter.2000;45(6):7-9.
It was shown that sulfur and phosphorus compounds (sodium thiosulfate, sodium tripolyphosphate, sodium hexametaphosphate, monosodium phosphate) catalyze cis-trans isomerization of aromatic heptaens. Preparative method of levorin isomerezation at the presence of sodium thiosulfate was elaborated. The
PMID 10904801

Japanese Journal

Alteration of Cell Wall Composition Leads to Amphotericin B Resistance in Aspergillus flavus

Seo Kuniko,Akiyoshi Hiroto,Ohnishi Yoshinari
Microbiology and immunology 43(11), 1017-1025, 1999-11-20
… The acquired resistance of mycelia was specific for polyene-antibiotics AmB, nystatin and trichomycin. …
NAID 10004791878

Trichomycin A, a heptaene macrolide: Isolation and characterization.

KOMORI TADAAKI,MORIMOTO YUKIYOSHI
The Journal of Antibiotics 43(7), 904-906, 1990
NAID 130003409965

Trichomycin B, a polyene macrolide from Streptomyces.

KOMORI TADAAKI
The Journal of Antibiotics 43(7), 778-782, 1990
… The two antibiotics were found to have the same molecular formula, C58H84N2O18 (MW 1, 096), by elemental analysis and FAB-MS. However, 1H and 13C NMR spectrometry studies indicated that the hydroxyl at C-5 of trichomycin A located on C-9 in trichomycin B. … Trichomycin B possessed lower activities against fungi and yeasts than those of trichomycin A. …
NAID 130003409950

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★リンクテーブル★

リンク元	「トリコマイシン」「hachimycin」「TRM」

「トリコマイシン」

Hachimycin
Systematic (IUPAC) name
	A: (19E,21E,23E,25E,27E,29E,31E)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-17-[7-(4-aminophenyl)-5-hydroxy-7-oxoheptan-2-yl]-1,3,5,9,11,37-hexahydroxy-18-methyl-13,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid; B: (19E,21E,23E,25E,27E,29E,31E)-33-{[(2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyloxan-2-yl]oxy}-17-[7-(4-aminophenyl)-5-hydroxy-7-oxoheptan-2-yl]-1,5,7,9,11,37-hexahydroxy-18-methyl-13,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid
Clinical data
Legal status	?
Identifiers
CAS number
ATC code	D01AA03 G01AA06 J02AA02
PubChem	CID 11979956
ChemSpider	10153168
Chemical data
Formula	C58H84N2O18
Mol. mass	1097.2902 g/mol
	InChI InChI=1S/2C58H84N2O18/c1-35-17-14-12-10-8-6-4-5-7-9-11-13-15-20-46(76-57-54(71)52(60)53(70)37(3)75-57)32-49-51(56(72)73)48(68)34-58(74,78-49)33-45(66)29-44(65)28-43(64)27-40(61)18-16-19-41(62)31-50(69)77-55(35)36(2)21-26-42(63)30-47(67)38-22-24-39(59)25-23-38;1-35-17-14-12-10-8-6-4-5-7-9-11-13-15-20-46(76-57-54(71)52(60)53(70)37(3)75-57)32-49-51(56(72)73)48(68)34-58(74,78-49)33-45(66)28-41(62)19-16-18-40(61)27-43(64)29-44(65)31-50(69)77-55(35)36(2)21-26-42(63)30-47(67)38-22-24-39(59)25-23-38/h4-15,17,20,22-25,35-37,40,42-46,48-49,51-55,57,61,63-66,68,70-71,74H,16,18-19,21,26-34,59-60H2,1-3H3,(H,72,73);4-15,17,20,22-25,35-37,40-43,45-46,48-49,51-55,57,61-64,66,68,70-71,74H,16,18-19,21,26-34,59-60H2,1-3H3,(H,72,73)/b5-4-,8-6-,9-7-,12-10-,13-11-,17-14-,20-15-;5-4+,8-6+,9-7+,12-10+,13-11+,17-14-,20-15+/t35?,36?,37-,40?,42?,43?,44?,45?,46?,48?,49?,51?,52+,53-,54+,55?,57+,58?;35?,36?,37-,40?,41?,42?,43?,45?,46?,48?,49?,51?,52+,53-,54+,55?,57+,58?/m11/s1 ; Key:RZWQQZWPVPHLSY-UGMBPVHXSA-N ;
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