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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/02 01:09:30」(JST)

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Trestolone (INN), also known as 7α-methyl-19-nortestosterone (MENT) or 17β-hydroxy-7α-methylestr-4-en-3-one, is a synthetic androgenic-anabolic steroid (AAS). It is used to build muscle rapidly^{[citation needed]} and is a theoretical candidate drug for use in hormonal male contraceptive methods.^[1] In males, regular administration of sufficient quantities of trestolone induces a reversible state of infertility.^[2]^{[unreliable medical source?]}

Trestolone is an experimental contraceptive treatment and is not yet available commercially. It is currently being evaluated for safety and effectiveness in scientific studies, supported by the Population Council.^[3]

Mechanism of action

As a derivative of the anabolic steroid hormone nandrolone (19-nortestosterone), trestolone's viability as a male contraceptive is two-fold.

Inhibition of sperm production

Spermatozoa are produced in the testes of males in a process called spermatogenesis. In order to render a man infertile, a hormone-based male contraceptive method must stop spermatogenesis by interrupting the release of gonadotropins from the pituitary gland. Even in low concentrations, trestolone is a potent inhibitor of the release of the gonadotropin hormones, luteinizing hormone (LH) and follicle stimulating hormone (FSH).^{[citation needed]}

In order for spermatogenesis to occur in the testes, both FSH and the male hormone testosterone must be present. By inhibiting release of FSH, trestolone creates an endocrine environment in which conditions for spermatogenesis are not ideal. Manufacture of sperm is further impaired by the suppression of LH, which in turn drastically curtails the production of testosterone. Sufficient regular doses of trestolone cause severe oligozoospermia or azoospermia, and therefore infertility, in most male patients.^{[citation needed]}

Trestolone-induced sterility has been found to be quickly reversible upon discontinuation. Anecdotal evidence shows a 45- to 90-day reversal in most people with stimulation of LH and FSH. This includes clomiphene and human chorionic gonadotropin^{[citation needed]}

Support of secondary sex characteristics

When LH release is inhibited, the amount of testosterone made in the testes declines dramatically. As a result of trestolone's gonadotropin-suppressing qualities, levels of serum testosterone fall sharply in patients. Testosterone is the primary hormone responsible for maintenance of male secondary sex characteristics.

Normally, inadequate testosterone levels cause undesirable effects, such as fatigue, loss of skeletal muscle mass, reduced libido, and weight gain. However, the androgenic and anabolic properties of trestolone largely ameliorate this problem. Essentially, trestolone replaces testosterone's role as the primary male hormone in the body.

References

^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 888–. ISBN 978-1-4757-2085-3.
^ http://www.ironmagazine.com/2012/trestolone-ment-explained/
^ MENT – project information from the Population Council

English Journal

Effects of luteinizing hormone and androgen on the development of rat progenitor Leydig cells in vitro and in vivo.

Guo JJ1, Ma X, Wang CQ, Ge YF, Lian QQ, Hardy DO, Zhang YF, Dong Q, Xu YF, Ge RS.
Asian journal of andrology.Asian J Androl.2013 Sep;15(5):685-91. doi: 10.1038/aja.2013.55. Epub 2013 Jun 24.
Progenitor Leydig cells are derived from stem cells. The proliferation and differentiation of progenitor Leydig cells significantly contributes to Leydig cell number during puberty. However, the regulation of these processes remains unclear. The objective of the present study was to determine whethe
PMID 23792342

7α-methyl-19-nortestosterone (MENTR): the population council's contribution to research on male contraception and treatment of hypogonadism.

Nieschlag E1, Kumar N, Sitruk-Ware R.
Contraception.Contraception.2013 Mar;87(3):288-95. doi: 10.1016/j.contraception.2012.08.036. Epub 2012 Oct 10.
Testosterone is an essential part of all regimens for hormonal male contraception tested to date. Initial efficacy trials revealed that the half-life of the testosterone preparations available at that time was too short to be used for male contraception. The ensuing search for long-acting preparatio
PMID 23063338

Comparison of 7α-methyl-19-nortestosterone effectiveness alone or combined with progestins on androgen receptor mediated-transactivation.

García-Becerra R1, Ordaz-Rosado D, Noé G, Chávez B, Cooney AJ, Larrea F.
Reproduction (Cambridge, England).Reproduction.2012 Feb;143(2):211-9. doi: 10.1530/REP-11-0171. Epub 2011 Nov 7.
7α-methyl-19-nortestosterone (MENT) is an androgen with potent gonadotropin inhibitory activity and prostate-sparing effects. These attributes give MENT advantages over testosterone as a male contraceptive, but, as in the case of testosterone, a partial dose-dependent suppression of spermatogenesis
PMID 22065861

Related Pictures

Trestolone Acetate raw powder - 1 Gram TRESTOLONE PHENYLPROPIONATE 10ML TRESTOLONE PHENYLPROP AND ACETATE Trestolone Acetate (Raw MENT) rawsteroids GP Ment (trestolone acetate) TRESTOLONE ACETATE 20ML DIENOLONE 5a TRESTOLONE New

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リンク元

「トレストロン」

Trestolone
Systematic (IUPAC) name
	17-hydroxy-7,13-dimethyl-2,6,7,8,9,10,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-one
Identifiers
CAS Number	3764-87-2
ATC code	none
PubChem	CID 9838899
ChemSpider	21106398
UNII	40P3287I94
Synonyms	MENT; 7α-Methylnandrolone; 7α-methyl-19-nortestosterone; 17β-hydroxy-7α-methylestr-4-en-3-one
Chemical data
Formula	C19H28O2
Molar mass	288.424 g/mol
	SMILES O=C2\C=C3\CC(C)[C@H]1[C@@H]4CCC(O)[C@@]4(C)CC[C@@H]1[C@H]3CC2 ;
	InChI InChI=1S/C19H28O2/c1-11-9-12-10-13(20)3-4-14(12)15-7-8-19(2)16(18(11)15)5-6-17(19)21/h10-11,14-18,21H,3-9H2,1-2H3/t11?,14-,15+,16-,17?,18+,19-/m0/s1 ; Key:YSGQGNQWBLYHPE-XOGXAEGHSA-N ;
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英: trestolone
同: 7α-メチル-19-ノルテストステロン 7α-methyl-19-nortestosterone

[Elks2014-1] J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 888–. ISBN 978-1-4757-2085-3.

[2] ttp://www.ironmagazine.com/2012/trestolone-ment-explained/

[3] MENT – project information from the Population Council

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案内

trestolone