treprostinil

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/02 16:44:33」(JST)

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Treprostinil

Systematic (IUPAC) name
(1R,2R,3aS,9aS)-[[2,3,3a,4,9,9a-hexahydro-2-hydroxy- 1-[(3S)-3-hydroxyoctyl]-1H-benz[f]inden-5-yl] oxy]acetic acid
Clinical data
Trade names	Remodulin, Tyvaso
AHFS/Drugs.com	Micromedex Detailed Consumer Information
MedlinePlus	a600042
Pregnancy category	B
Legal status	℞ (Prescription only)
Routes of administration	Subcutaneous or intravenous infusion, inhalation
Pharmacokinetic data
Bioavailability	approximately 100%
Metabolism	Treprostinil is substantially metabolized by the liver.
Half-life	4 hours
Excretion	Urine (79 % of administered dose is excreted in the urine as 4% unchanged drug and 64% as identified metabolites); feces (13%)
Identifiers
CAS Registry Number	289480-64-4 N
ATC code	B01AC21
PubChem	CID 6918140
DrugBank	DB00374 Y
ChemSpider	5293353 Y
UNII	RUM6K67ESG Y
ChEBI	CHEBI:50861 Y
ChEMBL	CHEMBL1201254 N
Chemical data
Formula	C23H34O5
Molecular mass	390.52 g/mol
InChI InChI=1S/C23H34O5/c1-2-3-4-7-17(24)9-10-18-19-11-15-6-5-8-22(28-14-23(26)27)20(15)12-16(19)13-21(18)25/h5-6,8,16-19,21,24-25H,2-4,7,9-14H2,1H3,(H,26,27)/t16-,17-,18+,19-,21+/m0/s1  Y Key:PAJMKGZZBBTTOY-ZFORQUDYSA-N  Y
N (what is this?)  (verify)

Treprostinil (marketed under the trade names Remodulin for infusion and Tyvaso for inhalation) is a vasodilator that is used for the treatment of pulmonary arterial hypertension. Treprostinil is a synthetic analog of prostacyclin (PGI₂).

Medical uses

Treprostinil is indicated for the treatment of pulmonary arterial hypertension in patients with NYHA Class II-IV symptoms to diminish symptoms associated with exercise. It may be administered as a continuous subcutaneous infusion or continuous intravenous infusion; however, because of the risks associated with chronic indwelling central venous catheters, including serious blood stream infections, continuous intravenous infusion should be reserved for patients who are intolerant of the subcutaneous route, or in whom these risks are considered warranted.

In patients with pulmonary arterial hypertension requiring transition from epoprostenol sodium (Flolan), treprostinil is indicated to diminish the rate of clinical deterioration. The risks and benefits of each drug should be carefully considered prior to transition.

There is a report that Treprostinil has improved signs and symptoms in Malignant Atrophic Papulosis.

Adverse affects

• Since treprostinil is a vasodilator, its antihypertensive effect may be compounded by other medications that affect the blood pressure, including calcium channel blockers, diuretics, and other vasodilating agents.
• Because of treprostinil's inhibiting effect on platelet aggregation, there is an increased risk of bleeding, especially among patients who are also taking anticoagulants.
• It is not known whether treprostinil is excreted in breast milk. Caution is advised when administering this medication to nursing women.
• Caution is advised when administering treprostinil to patients who have impaired kidney or liver function.

Common side effects:

• 85% of patients report pain or other reaction at the infusion site. Other side effects may include headache, diarrhea, nausea, rash, jaw pain, vasodilatation, dizziness, edema (swelling), pruritus (itching), and hypotension.

Warnings:

• Abrupt interruption of the treprostinil infusion can lead to worsening of pulmonary hypertension symptoms, and should be avoided.

Mechanism of action

The major effects of treprostinil are vasodilation of arteries in the pulmonary (lung) and body. Treprostinil also inhibits platelet aggregation.

Pharmacokinetics

The pharmacokinetics of continuous subcutaneous treprostinil are linear over the dose range of 1.25 to 125 ng/kg/min (corresponding to plasma concentrations of about 15 pg/mL to 18,250 pg/m) and can be described by a two-compartment model. Dose proportionality at infusion rates greater than 125 ng/kg/min has not been studied.

Treprostinil is substantially metabolized by the liver, but the involved enzymes are not currently known. Five metabolites (HU1 through HU5) have been described thus far. Based on the results of in vitro human hepatic cytochrome P450 studies, Remodulin does not inhibit CYP-1A2, 2C9, 2C19, 2D6, 2E1, or 3A. Whether Remodulin induces these enzymes has not been studied.

Dosage and administration

Treprostinil may be administered as a continuous subcutaneous infusion or continuous intravenous infusion via a small infusion pump that the patient must wear at all times. Treprostinil can be given subcutaneously by continuous infusion using an infusion set connected to an infusion pump, but also may be given intravenously via a central venous catheter if the patient is unable to tolerate subcutaneous administration because of severe site pain or reaction.

Remodulin is supplied in 20 mL vials, containing treprostinil in concentrations of 1 mg/mL, 2.5 mg/mL, 5 mg/mL, and 10 mg/mL. Treprostinil can be administered subcutaneously as supplied. It must be diluted for intravenous infusion with either sterile water or a 0.9% sodium chloride solution prior to administration.

The infusion rate is normally initiated at 1.25 ng/kg/min for new patients, but may be reduced to 0.625 ng/kg/min if the normal rate provokes unwanted side effects in the patient. The infusion rate of treprostinil should be increased no more than 1.25 ng/kg/min per week for the first month, then 2.5 ng/kg/min per week for the remaining duration of infusion. The infusion rate should ideally be high enough to improve symptoms of pulmonary hypertension, while minimizing unpleasant side effects (headache, nausea, emesis, restlessness, anxiety and infusion site pain or reaction). Dosage adjustments may be undertaken more often if tolerated. There is little experience with doses >40 ng/kg/min. Abrupt cessation of infusion should be avoided. Restarting a Remodulin infusion within a few hours after an interruption can be done using the same dose rate. Interruptions for longer periods may require the dose of Remodulin to be re-titrated.

In patients with mild or moderate liver dysfunction, the initial dose of Remodulin should be decreased to 0.625 ng/kg/min ideal body weight and should be increased cautiously. Remodulin has not been studied in patients with severe liver dysfunction.

No studies have been performed in patients with kidney dysfunction. No specific advice about dosing in patients with renal impairment can be given.

The oral form of treprostinil is currently undergoing clinical trials. The inhaled form of treprostinil was approved by the FDA in July 2009 and is marketed as the trade name Tyvaso. The inhaled form is used with a proprietary inhalation device supplied by the manufacturer. Patients use one ampule with inhalation solution a day, four times a day at least four hours apart.

History

During the 1960s a U.K. research team, headed by Professor John Vane began to explore the role of prostaglandins in anaphylaxis and respiratory diseases. Working with a team from the Royal College of Surgeons, Vane discovered that aspirin and other oral anti-inflammatory drugs worked by inhibiting the synthesis of prostaglandins. This finding opened the door to a broader understanding of the role of prostaglandins in the body.

Vane and a team from the Wellcome Foundation had identified a lipid mediator they called “PG-X,” which inhibited platelet aggregation. PG-X, which later would become known as prostacyclin, was 30 times more potent than any other known anti-aggregatory agent.

By 1976, Vane and fellow researcher Salvador Moncada published the first paper on prostacyclin, in the scientific journal Nature. The collaboration produced a synthetic molecule which was given the name epoprostenol. But like native prostacyclin, the structure of the epoprostenol molecule proved to be unstable in solution, prone to rapid degradation. This presented a challenge for both in vitro experiments and clinical applications. To overcome this challenge, the research team that discovered prostacyclin was determined to continue the research in an attempt to build upon the success they had seen with the prototype molecule. The research team synthesized nearly 1,000 analogs.

Treprostinil has demonstrated a unique effect on PPAR gamma, a transcription factor important in vascular pathogenesis as a mediator of proliferation, inflammation and apoptosis. Through a complementary, yet cyclic AMP-independent pathway, treprostinil activates PPARs, another mechanism that contributes to the anti-growth benefits of the prostacyclin class.

References

Further reading

• Narine L, Hague LK, Walker JH, Vicente C, Schilz R, Desjardins O, Einarson TR, Iskedjian M (December 2005). "Cost-minimization analysis of treprostinil vs. epoprostenol as an alternate to oral therapy non-responders for the treatment of pulmonary arterial hypertension". Curr Med Res Opin 21 (12): 2007–16. doi:10.1185/030079905X75104. PMID 16368052. 

1. Remodulin Full Prescribing Information US Patent No. 5,153,222
2. UT_OpinVEvid_FEB09v.1

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 成人における肺高血圧症の治療 treatment of pulmonary hypertension in adults
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• 4. ヒト免疫不全ウイルス（HIV）関連肺動脈性高血圧症 pulmonary arterial hypertension associated with human immunodeficiency virus
• 5. 慢性血栓塞栓性肺高血圧症：内科的治療 chronic thromboembolic pulmonary hypertension medical treatment

English Journal

• Safety and efficacy of transition from systemic prostanoids to inhaled treprostinil in pulmonary arterial hypertension.

• de Jesus Perez VA, Rosenzweig E, Rubin LJ, Poch D, Bajwa A, Park M, Jain M, Bourge RC, Kudelko K, Spiekerkoetter E, Liu J, Hsi A, Zamanian RT.SourceStanford University, Stanford, California. Electronic address: vdejesus@stanford.edu.
• The American journal of cardiology.Am J Cardiol.2012 Nov 15;110(10):1546-50. doi: 10.1016/j.amjcard.2012.07.012. Epub 2012 Jul 30.
• Pulmonary arterial hypertension (PAH) is a disease characterized by increased pulmonary pressures and chronic right heart failure. Therapies for moderate and severe PAH include subcutaneous (SQ) and intravenous (IV) prostanoids that improve symptoms and quality of life. However, treatment compliance
• PMID 22853986

• Experiences with treprostinil in the treatment of pulmonary arterial hypertension.

• Stream AR, Bull TM.SourceUniversity of Colorado Health Sciences Center, Aurora, CO, USA.
• Therapeutic advances in respiratory disease.Ther Adv Respir Dis.2012 Oct;6(5):269-76. Epub 2012 Aug 6.
• Pulmonary arterial hypertension (PAH) is a chronic condition of elevated pulmonary arterial pressures with associated increases in pulmonary vascular resistance leading to right ventricular failure, which was almost uniformly fatal prior to the introduction of pulmonary hypertension specific therapy
• PMID 22868690

Japanese Journal

• トレプロスチニル（トレプロスト^®注射液）の薬理学的特徴および臨床試験成績

• 日本薬理学雑誌 147(1), 56-62, 2016
• NAID 130005118587

• 小児期肺動脈性高血圧の正しく的確な治療戦略

• 日本小児循環器学会雑誌 31(4), 157-183, 2015
• NAID 130005098178

• Pathological function of Ca²⁺-sensing receptor in pulmonary arterial hypertension

• Journal of Smooth Muscle Research 50(0), 8-17, 2014
• NAID 130003391244

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