トレピブトン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/02/13 00:17:24」(JST)
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Trepibutone
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Systematic (IUPAC) name |
4-Oxo-4-(2,4,5-triethoxyphenyl)butanoic acid |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy cat. |
? |
Legal status |
? |
Identifiers |
CAS number |
41826-92-0 |
ATC code |
A03AX09 |
PubChem |
CID 5536 |
ChemSpider |
5335 |
UNII |
H1187LU49Q Y |
Chemical data |
Formula |
C16H22O6 |
Mol. mass |
310.34 g/mol |
Trepibutone is a drug used for functional gastrointestinal disorders.
Drugs for functional gastrointestinal disorders (A03)
|
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Drugs for
functional bowel disorders |
Antimuscarinics
|
Tertiary
amino group
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- Oxyphencyclimine
- Camylofin
- Mebeverine
- Trimebutine
- Rociverine
- Dicycloverine
- Dihexyverine
- Difemerine
- Piperidolate
|
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Quaternary ammonium
compounds
|
- Benzilone
- Mepenzolate
- Pipenzolate
- Glycopyrronium
- Oxyphenonium
- Penthienate
- Methantheline
- Propantheline
- Otilonium
- Tridihexethyl
- Isopropamide
- Hexocyclium
- Poldine
- Bevonium
- Diphemanil
- Tiemonium
- Prifinium
- Timepidium
- Fenpiverinium
|
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Phosphodiesterase inhibitors
|
- Papaverine
- Drotaverine
- Moxaverine
|
|
Acting on serotonin receptors
|
- 5-HT3 antagonists
- 5-HT4 agonists
- Mosapride
- Prucalopride
- Tegaserod
|
|
Other
|
- Alverine
- Caroverine
- Chlorbenzoxamine
- Diisopromine
- Dimethylaminopropionylphenothiazine
- Fenpiprane
- Fenoverine
- Idanpramine
- Isometheptene
- Phloroglucinol
- Pinaverium
- Proxazole
- Silicones
- Tiropramide
- Trepibutone
- Trimethyldiphenylpropylamine
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Belladonna and derivatives
(antimuscarinics) |
- tertiary amines: Atropine
- Hyoscyamine
- quaternary ammonium compounds:
- Scopolamine
- Butylscopolamine
- Methylscopolamine
- Methylatropine
- Fentonium
- Cimetropium bromide
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Propulsives |
- primarily dopamine antagonists
- Metoclopramide/Bromopride
- Clebopride
- Domperidone
- Alizapride
- 5-HT4 agonists
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anat (t, g, p)/phys/devp/enzy
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noco/cong/tumr, sysi/epon
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proc, drug (A2A/2B/3/4/5/6/7/14/16), blte
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English Journal
- pH-independent controlled-release microspheres using polyglycerol esters of fatty acids.
- Akiyama Y, Yoshioka M, Horibe H, Hirai S, Kitamori N, Toguchi H.SourceDDS Research Laboratories, Takeda Chemical Industries, Ltd., Osaka, Japan.
- Journal of pharmaceutical sciences.J Pharm Sci.1994 Nov;83(11):1600-7.
- The release of a drug having low solubility in a certain pH range from controlled-release microspheres using tetraglycerol pentastearate and tetraglycerol monostearate in combination as the matrix base showed pH dependence. Trepibutone, an acidic drug having lower solubility in an acidic medium, was
- PMID 7891282
Japanese Journal
- ROLE OF AN INTRACELLULAR Ca STORE IN TREPIBUTONE (AA-149)-INDUCED RELAXATION OF THE DEPOLARIZED SMOOTH MUSCLE OF THE GUINEA-PIG TAENIA COLI
- SATOH Hiroshi,INADA Ikuko,MAKI Yoshitaka
- The Japanese Journal of Pharmacology 31(4), 593-599, 1981
- … Trepibutone, a newly synthesized smooth muscle relaxant, given before CaCl<SUB>2</SUB> … The CCh contraction was enhanced after inhibition of the Ca contracture by trepibutone. … The inhibitory effect of trepibutone on the Ca contracture was markedly reduced in the presence of CCh, whereas that of D-600 was not affected. …
- NAID 130000835649
- RELAXING ACTION OF TREPIBUTONE (AA-149) ON THE ISOLATED SPHINCTER OF ODDI AND SMALL INTESTINE OF RABBITS
- SATOH Hiroshi,INADA Ikuko,MAKI Yoshitaka
- The Japanese Journal of Pharmacology 31(4), 587-592, 1981
- … We investigated the smooth muscle relaxing action of trepibutone [3-(2, 4, 5-triethoxybenzoyl)pro pi onic acid: AA-149] using assays of the isolated preparations of sphincter of Oddi, duodenum, jejunum and ileum of rabbits. … Trepibutone (10<SUP>-6</SUP>-10<SUP>-3</SUP> … The actions of trepibutone were not altered by pretreatment with tetrodotoxin, phentolamine or propranolol. …
- NAID 130000835648
- 慢性再発性膵炎に対するAA-149(trepibutone)の臨床的検討
Related Links
- Trepibutone. From Wikipedia, the free encyclopedia. Jump to: navigation, search. Trepibutone. Systematic (IUPAC) name ... Trepibutone is a drug used for functional gastrointestinal disorders. v · t · e. Drugs for functional gastrointestinal ...
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