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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/15 10:06:18」(JST)

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One 2.5 ml dropperette of Alcon Travatan

Travoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a synthetic prostaglandin analog (or more specifically, an analog of prostaglandin F_2α)^[1]^[2] that works by increasing the outflow of aqueous fluid from the eyes.^[3] It is also known by the brand names of Travatan and Travatan Z, manufactured by Alcon, and Travo-Z, manufactured by Micro Labs.

Side effects

Possible side effects of this medication are:

May cause blurred vision
May cause eyelid redness
May permanently darken eyelashes
May cause eye discomfort
May eventually cause permanent darkening of the iris to brown (heterochromia)
May cause a temporary burning sensation during use
May cause thickening of the eyelashes
May cause inflammation of the prostate gland, restricting urine flow (BPH)

References

^ Alcon Laboratories, Inc. (September 2011). "TRAVATAN - travoprost solution". DailyMed. Bethesda, MD: U.S. National Library of Medicine. Retrieved 2011-09-30.
^ Alcon Laboratories, Inc. (September 2011). "TRAVATAN Z (travoprost) solution". DailyMed. Bethesda, MD: U.S. National Library of Medicine. Retrieved 2011-09-30.
^ AHFS Consumer Medication Information (2011-01-01). "Travoprost Ophthalmic". MedlinePlus. Bethesda, MD: U.S. National Library of Medicine. Retrieved 2011-09-30.

UpToDate Contents

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1. 原発性乳児緑内障 primary infantile glaucoma

English Journal

Ocular hypotensive effect of fixed-combination brinzolamide/brimonidine adjunctive to a prostaglandin analog: a randomized clinical trial.

Fechtner RD1, Myers JS2, Hubatsch DA3, Budenz DL4, DuBiner HB5.
Eye (London, England).Eye (Lond).2016 Jul 1. doi: 10.1038/eye.2016.126. [Epub ahead of print]
PurposeTo determine whether intraocular pressure (IOP) lowering with fixed-combination brinzolamide/brimonidine (BBFC) adjunctive to a prostaglandin analog (PGA) was superior to that of vehicle+PGA in patients with open-angle glaucoma or ocular hypertension who were inadequately controlled with PGA
PMID 27367743

Effect of Travoprost and Nonsteroidal Anti-Inflammatory Drug on Diurnal Intraocular Pressure in Normal Subjects with Low-Teen Baseline Intraocular Pressure.

Sakata R1, Sakisaka T1, Matsuo H2, Miyata K3, Aihara M1.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.J Ocul Pharmacol Ther.2016 Jun 13. [Epub ahead of print]
PURPOSE: The main purpose was to determine whether a nonsteroidal anti-inflammatory drug (NSAID) ophthalmic solution would affect the intraocular pressure (IOP)-lowering effect of a benzalkonium chloride (BAK)-free prostaglandin analog, travoprost. The secondary purpose was to confirm the IOP-loweri
PMID 27294589

Tafluprost Ophthalmic Solution 0.0015 %: A Review in Glaucoma and Ocular Hypertension.

Keating GM1.
Clinical drug investigation.Clin Drug Investig.2016 Jun;36(6):499-508. doi: 10.1007/s40261-016-0413-z.
Tafluprost ophthalmic solution 0.0015 % preserved with benzalkonium chloride (BAK) 0.001 % is available in several Asian countries, including Japan. In pivotal trials, BAK-preserved tafluprost ophthalmic solution 0.0015 % lowered intraocular pressure (IOP) more effectively than placebo in Asian p
PMID 27225879

Japanese Journal

塩化ベンザルコニウム非含有トラボプロスト点眼薬の球結膜充血

比嘉利沙子,井上賢治,塩川美菜子,菅原道孝,増本美枝子,若倉雅登,相原一,富田剛司
あたらしい眼科 = Journal of the eye 28(4), 563-567, 2011-04-30
NAID 10028248220

3種のプロスタグランジン製剤の眼圧下降効果の比較検討

木村健一,長谷川謙介,寺井和都
あたらしい眼科 = Journal of the eye 28(3), 441-443, 2011-03-30
NAID 10028247986

Changes to Upper Eyelid Orbital Fat from Use of Topical Bimatoprost, Travoprost, and Latanoprost

PARK Juwan,CHO Hyun Kyung,MOON Jung-Il
Japanese journal of ophthalmology 55(1), 22-27, 2011-01-01
NAID 10029020489

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リンク元

「トラボプロスト」

Travoprost
Systematic (IUPAC) name
	propan-2-yl 7-[3,5-dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl); phenoxy]-but-1-enyl]-cyclopentyl]hept-5-enoate
Clinical data
Trade names	Travatan, Travoprostin is the brand name which is available in preservative free form in India by Eyekare Kilitch Ltd.
AHFS/Drugs.com	monograph
MedlinePlus	a602027
Pregnancy; category	C US;
Legal status	Rx only (US);
Routes of; administration	Topical (eye drops)
Identifiers
CAS Number	157283-68-6
ATC code	S01EE04
PubChem	CID 5282226
IUPHAR/BPS	7102
DrugBank	DB00287
ChemSpider	4445407
UNII	WJ68R08KX9
KEGG	D01964
ChEBI	CHEBI:746859
ChEMBL	CHEMBL1200799
Chemical data
Formula	C26H35F3O6
Molar mass	500.548 g/mol
	SMILES FC(F)(F)c2cc(OC[C@H](O)/C=C/[C@@H]1[C@H]([C@@H](O)C[C@H]1O)C\C=C/CCCC(=O)OC(C)C)ccc2 ;
	InChI InChI=1S/C26H35F3O6/c1-17(2)35-25(33)11-6-4-3-5-10-21-22(24(32)15-23(21)31)13-12-19(30)16-34-20-9-7-8-18(14-20)26(27,28)29/h3,5,7-9,12-14,17,19,21-24,30-32H,4,6,10-11,15-16H2,1-2H3/b5-3-,13-12+/t19-,21-,22-,23+,24-/m1/s1 ; Key:MKPLKVHSHYCHOC-AHTXBMBWSA-N ;
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英: travoprost
関: デュオトラバ配合、トラバタンズ
関: 眼科用剤

-travoprost

[MedlineTravatan-1] Alcon Laboratories, Inc. (September 2011). "TRAVATAN - travoprost solution". DailyMed. Bethesda, MD: U.S. National Library of Medicine. Retrieved 2011-09-30.

[MedlineTravatanZ-2] Alcon Laboratories, Inc. (September 2011). "TRAVATAN Z (travoprost) solution". DailyMed. Bethesda, MD: U.S. National Library of Medicine. Retrieved 2011-09-30.

[MedlinePlusTravoprost-3] AHFS Consumer Medication Information (2011-01-01). "Travoprost Ophthalmic". MedlinePlus. Bethesda, MD: U.S. National Library of Medicine. Retrieved 2011-09-30.

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travoprost