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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/05/30 17:05:19」(JST)
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Definition of transitions and transversions.
Transversion, in molecular biology, refers to the substitution of a (two ring) purine for a (one ring) pyrimidine or conversely in deoxyribonucleic acid (DNA).[1] It can only be reversed by a spontaneous reversion.
Although there are two possible transversions but only one possible transition, transition mutations are more likely than transversions because substituting a single ring structure for another single ring structure is more likely than substituting a double ring for a single ring. Also, transitions are less likely to result in amino acid substitutions (due to "wobble"), and are therefore more likely to persist as "silent substitutions" in populations as single nucleotide polymorphisms (SNPs).[2] A transversion usually has a more pronounced effect than a transition because the third nucleotide codon position of the DNA, which to a large extent is responsible for the degeneracy of the code, is more tolerant of transition than a transversion: that is, a transition is more likely to encode for the same amino acid.
Transversions can be spontaneous, or can be caused by ionizing radiation or alkylating agents.
See also
References
- ^ Futuyma, D.J. (2013). Evolution (3rd ed.). Sinauer. ISBN 978-1605351155.
- ^ Diagram at mun.ca
External links
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Wikimedia Commons has media related to Transversion. |
- Carr, Steven M. "Transition versus Transversion mutations". Memorial University of Newfoundland.
- Nikolay's Genetics Lessons (2014). Transition versus Transversion mutations (how to memorize). Youtube.
Mutation
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Mechanisms of mutation |
- Insertion
- Deletion
- Substitution
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Mutation with respect to structure |
Point mutation
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- Nonsense mutation
- Missense mutation
- Silent mutation
- Frameshift mutation
- Dynamic mutation
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Large-scale mutation
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- Chromosomal translocations
- Chromosomal inversions
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Mutation with respect to overall fitness |
- Deleterious mutation
- Advantageous mutation
- Neutral mutation
- Nearly neutral mutation
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Related Links
- 生理的、遺伝的な影響としてはtransitionもtransversionも違いはありません(つまり、影響のある場合も全くない場合もあるというところは同じ)。 自然変異ではどちらも同程度起こっていますが、化学変異原でおこる塩基置換は ...
- Transition versus Transversion mutations DNA substitution mutations are of two types. Transitions are interchanges of two-ring purines (A G) or of one-ring pyrimidines (C T): they therefore involve bases of. Transversions purine for , ...
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