- 関
- transmethylate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/01/23 21:52:10」(JST)
[Wiki en表示]
The recovery of methionine from homocysteine by transmethylation is depicted in reaction 4. The transmethylation cycle is depicted in reactions 1–4.
Transmethylation is a biologically important organic chemical reaction in which a methyl group is transferred from one compound to another.
An example of transmethylation is the recovery of methionine from homocysteine. In order to sustain sufficient reaction rates during metabolic stress, this reaction requires adequate levels of vitamin B12 and folic acid. Methyl tetrahydrofolate delivers methyl groups to form the active methyl form of vitamin B12 that is required for methylation of homocysteine. Deficiencies of vitamin B12 or folic acid cause increased levels of circulating homocysteine. Elevated homocysteine is a risk factor for cardiovascular disease and is linked to the metabolic syndrome (insulin insensitivity).[1]
Transmethylation is decreased sometimes in parents of children with autism.[2]
See also[edit]
References[edit]
- ^ Carmel R, Green R, Rosenblatt DS, Watkins D (2003). "Update on cobalamin, folate, and homocysteine". Hematology Am Soc Hematol Educ Program 2003: 62–81. doi:10.1182/asheducation-2003.1.62. PMID 14633777.
- ^ James SJ, Jill James S, Melnyk S, Jernigan S, Hubanks A, Rose S, Gaylor DW (November 2008). "Abnormal transmethylation/transsulfuration metabolism and DNA hypomethylation among parents of children with autism". J Autism Dev Disord 38 (10): 1966–75. doi:10.1007/s10803-008-0591-5. PMC 2584168. PMID 18512136.
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- On the transmethylation hypothesis: stress, N,N-dimethyltryptamine, and positive symptoms of psychosis.
- Grammenos D1, Barker SA.
- Journal of neural transmission (Vienna, Austria : 1996).J Neural Transm.2015 Jun;122(6):733-9. doi: 10.1007/s00702-014-1329-5. Epub 2014 Nov 2.
- Past research suggests a relationship between stress and positive symptoms of psychosis. However, the biological substrate of this relationship remains unknown. According to the transmethylation hypothesis, schizophrenia could result from a biochemical disruption in the stress mechanism. This bioche
- PMID 25362533
- A Dedicated Type II NADPH Dehydrogenase Performs the Penultimate Step in the Biosynthesis of Vitamin K1 in Synechocystis and Arabidopsis.
- Fatihi A1, Latimer S1, Schmollinger S2, Block A1, Dussault PH3, Vermaas WF4, Merchant SS5, Basset GJ6.
- The Plant cell.Plant Cell.2015 May 28. pii: tpc.15.00103. [Epub ahead of print]
- Mutation of Arabidopsis thaliana NAD(P)H DEHYDROGENASE C1 (NDC1; At5g08740) results in the accumulation of demethylphylloquinone, a late biosynthetic intermediate of vitamin K1. Gene coexpression and phylogenomics analyses showed that conserved functional associations occur between vitamin K biosynt
- PMID 26023160
- PMID 25931143
Japanese Journal
- 酸化カルシウム触媒を用いる油脂からのバイオディーゼル燃料製造におけるトランスメチル化触媒活性の向上の検討
- 岑 友里恵,大藪 真弓,伊藤 亜季乃 [他],西田 晶子,福永 公寿,渡辺 高行,三隅 修
- 化学工学論文集 36(3), 264-269, 2010-07-20
- 環境負荷の少ない油脂からのバイオディーゼル燃料(BDF)製造のための触媒として酸化カルシウム(CaO)を検討した.石灰石を大気中で焼成して得られる工業用CaO(CaO-E)は米油のトランスメチル化反応を触媒したが,脂肪酸メチルエステル(FAME)の収率は2 hで8.3%でしかなかった.しかし,そのCaOを水和して,一旦,消石灰(Ca(OH)2)としたもの,および市販試薬Ca(OH)2を425°C, …
- NAID 10027040756
- ビタミンB_<12>と精子形成(<特集>「ビタミン・ミネラルと生殖」[I])
- 山田 和弘,河田 哲典,前川 昭男
- ビタミン 82(1), 11-17, 2008-01-25
- … Methionine synthase is one of key enzymes in methionine and folate metabolism, which is important for nucleic acid synthesis, protein synthesis, polyamine synthesis, and transmethylation. …
- NAID 110006571393
- Hepatic transmethylation reactions in micropigs with alcoholic liver disease
Related Links
- This amino acid metabolism lecture explains about Transmethylation. http://shomusbiology.weebly.com/ Download the study materials here- http://shomusbiology.weebly.com/bio-m... Transmethylation is a ...
- transmethylation trans·meth·yl·a·tion (trāns-měth'ə-lā'shən, trānz-) n. The transfer of a methyl group from one compound to another.
Related Pictures
★リンクテーブル★
[★]
- 関
- transmethylation
[★]
- 英
- transmethylation、transmethylate