English Journal

Establishment of a functional secretory IgA transcytosis model system in vitro for functional food screening.

Zuo T1, Feng X, Zhang N, Xue C, Tang QJ.
Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2015 Jul;99(13):5535-45. doi: 10.1007/s00253-015-6501-9. Epub 2015 Mar 18.
A characteristic mucosal immune response involves the production of antigen-specific secretory immunoglobulin A (SIgA) antibodies. In order to study transcytosis by mimicking the SIgA secretion and to screen for SIgA secretion-promoting substances, we developed a model system of a transfected Madin-
PMID 25776060

Identifying low-level sequence variants via next generation sequencing to aid stable CHO cell line screening.

Zhang S1, Bartkowiak L1, Nabiswa B1, Mishra P1, Fann J1, Ouellette D2, Correia I2, Regier D3, Liu J3.
Biotechnology progress.Biotechnol Prog.2015 May 29. doi: 10.1002/btpr.2119. [Epub ahead of print]
Developing stable Chinese hamster ovary (CHO) cell lines for biotherapeutics is an irreversible process and therefore, key quality attributes, such as sequence variants, must be closely monitored during cell line development (CLD) to avoid delay in the developmental timeline, and more importantly, t
PMID 26033952

Li R1, Shi X, Ling F, Wang C, Liu J, Wang W, Li M.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.Tumour Biol.2015 Apr 21. [Epub ahead of print]
Increasing evidence has suggested that dysregulation of microRNAs (miRNAs) could contribute to tumor progression. The miR-34 family is directly transactivated by tumor suppressor p53 which is frequently mutated in various cancers; however, the effect of miR-34a on the ovarian cancer cells remains un
PMID 25895459

Japanese Journal

Stable Expression and Characterization of Monomeric and Dimeric Recombinant Hybrid-IgG/IgA Immunoglobulins Specific for Shiga Toxin

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Biological and Pharmaceutical Bulletin 37(9), 1510-1515, 2014
… In the transfectant for the dimeric hybrid-IgG/IgA, both monomers and dimers were observed. …
NAID 130004147362

Immunohistochemical Examination of Novel Rat Monoclonal Antibodies against Mouse and Human Podoplanin

Kaji Chiaki,Tsujimoto Yuta,Kato Kaneko Mika,Kato Yukinari,Sawa Yoshihiko
ACTA HISTOCHEMICA ET CYTOCHEMICA 45(4), 227-237, 2012
… In immunocytochemistry, the mouse melanoma B16-F10 and mouse podoplanin (mPDPN)-expressed CHO transfectant were stained by PMab-1; … human lymphatic endothelial cells (LEC) and human podoplanin (hPDPN)-expressed squamous cell carcinoma HSC3 transfectant, were stained by NZ-1.2. …
NAID 130001854251

Cycloheximide Suppresses Radiation-induced Apoptosis in MOLT-4 Cell with Arg72 Variant of p53 through Translational Inhibition of p53 Accumulation

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Journal of radiation research 52(3), 342-350, 2011-05-16
… We also revealed that the suppressive effect of CHX on apoptosis was specifically mediated by p53, using a p53-knockdown MOLT-4 transfectant. …
NAID 10028111380