- adv.
- 中毒学的に、毒物学的に
WordNet
- of or relating to toxicology (同)toxicologic
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- 1. 成人における薬物中毒への一般的アプローチ general approach to drug poisoning in adults
- 2. 潜在性毒素曝露を認める小児に対するアプローチ approach to the child with occult toxic exposure
- 3. 第二世代（非定型）抗精神病薬中毒 second generation atypical antipsychotic medication poisoning
- 4. 抗コリン剤中毒 anticholinergic poisoning
- 5. 成人における急性オピオイド中毒 acute opioid intoxication in adults
English Journal
- Quaternized magnetic nanoparticles-fluorescent polymer system for detection and identification of bacteria.
- Wan Y1, Sun Y1, Qi P2, Wang P1, Zhang D3.Author information 1Key Laboratory of Marine Environmental Corrosion and Bio-fouling, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China.2Key Laboratory of Marine Environmental Corrosion and Bio-fouling, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China; University of Chinese Academy of Sciences, 19 (Jia) Yuquan Road, Beijing 100039, China.3Key Laboratory of Marine Environmental Corrosion and Bio-fouling, Institute of Oceanology, Chinese Academy of Sciences, 7 Nanhai Road, Qingdao 266071, China. Electronic address: zhangdun@qdio.ac.cn.AbstractNanomaterial-based 'chemical nose' sensor with sufficient sensing specificity is a useful analytical tool for the detection of toxicologically important substances in complicated biological systems. A sensor array containing three quaternized magnetic nanoparticles (q-MNPs)-fluorescent polymer systems has been designed to identify and quantify bacteria. The bacterial cell membranes disrupt the q-MNP-fluorescent polymer, generating unique fluorescence response array. The response intensity of the array is dependent on the level of displacement determined by the relative q-MNP-fluorescent polymer binding strength and bacteria cells-MNP interaction. These characteristic responses show a highly repeatable bacteria cells and can be differentiated by linear discriminant analysis (LDA). Based on the array response matrix from LDA, our approach has been used to measure bacteria with an accuracy of 87.5% for 10(7)cfumL(-1) within 20min. Combined with UV-vis measurement, the method can be successfully performed to identify and detect eight different pathogen samples with an accuracy of 96.8%. The measurement system has a potential for further applications and provides a facile and simple method for the rapid analysis of protein, DNA, and pathogens.
- Biosensors & bioelectronics.Biosens Bioelectron.2014 May 15;55:289-93. doi: 10.1016/j.bios.2013.11.080. Epub 2013 Dec 12.
- Nanomaterial-based 'chemical nose' sensor with sufficient sensing specificity is a useful analytical tool for the detection of toxicologically important substances in complicated biological systems. A sensor array containing three quaternized magnetic nanoparticles (q-MNPs)-fluorescent polymer syste
- PMID 24398123
- Mechanisms of Hg species induced toxicity in cultured human astrocytes: genotoxicity and DNA-damage response.
- Pieper I1, Wehe CA, Bornhorst J, Ebert F, Leffers L, Holtkamp M, Höseler P, Weber T, Mangerich A, Bürkle A, Karst U, Schwerdtle T.Author information 1Institute of Food Chemistry, University of Münster, Corrensstr. 45, 48149 Münster, Germany.AbstractThe toxicologically most relevant mercury (Hg) species for human exposure is methylmercury (MeHg). Thiomersal is a common preservative used in some vaccine formulations. The aim of this study is to get further mechanistic insight into the yet not fully understood neurotoxic modes of action of organic Hg species. Mercury species investigated include MeHgCl and thiomersal. Additionally HgCl2 was studied, since in the brain mercuric Hg can be formed by dealkylation of the organic species. As a cellular system astrocytes were used. In vivo astrocytes provide the environment necessary for neuronal function. In the present study, cytotoxic effects of the respective mercuricals increased with rising alkylation level and correlated with their cellular bioavailability. Further experiments revealed for all species at subcytotoxic concentrations no induction of DNA strand breaks, whereas all species massively increased H2O2-induced DNA strand breaks. This co-genotoxic effect is likely due to a disturbance of the cellular DNA damage response. Thus, at nanomolar, sub-cytotoxic concentrations, all three mercury species strongly disturbed poly(ADP-ribosyl)ation, a signalling reaction induced by DNA strand breaks. Interestingly, the molecular mechanism behind this inhibition seems to be different for the species. Since chronic PARP-1 inhibition is also discussed to sacrifice neurogenesis and learning abilities, further experiments on neurons and in vivo studies could be helpful to clarify whether the inhibition of poly(ADP-ribosyl)ation contributes to organic Hg induced neurotoxicity.
- Metallomics : integrated biometal science.Metallomics.2014 Mar 26;6(3):662-71. doi: 10.1039/c3mt00337j. Epub 2014 Feb 19.
- The toxicologically most relevant mercury (Hg) species for human exposure is methylmercury (MeHg). Thiomersal is a common preservative used in some vaccine formulations. The aim of this study is to get further mechanistic insight into the yet not fully understood neurotoxic modes of action of organi
- PMID 24549367
- Biodegradable Gelatin Microspheres Enhance the Neuroprotective Potency of Osteopontin via Quick and Sustained Release in the Postischemic Brain.
- Jin YC1, Kim IY2, Kim ID1, Lee HK1, Park JY3, Han PL4, Kim KK5, Choi H6, Lee JK7.Author information 1Department of Anatomy, Inha University School of Medicine, Inchon, Korea; Inha Research Institute for Medical Sciences, Inha University School of Medicine, Inchon, Korea.2Department of Electrical and Computer Engineering, University of Illinois, Urbana, Il 61801.3Departments of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Republic of Korea.4Departments of Brain and Cognitive Sciences, Ewha Womans University, Seoul, Republic of Korea; Chemistry and Nano Science, Ewha Womans University, Seoul, Republic of Korea.5Department of Electrical and Computer Engineering, University of Illinois, Urbana, Il 61801; Micro and Nanotechnology Laboratory, University of Illinois, Urbana, Il 61801; Department of Bioengineering, University of Illinois, Urbana, Il 61801; Department of Material Science and Engineering, University of Illinois, Urbana, Il 61801; University of Illinois Neuroscience Program, Urbana, Il 61801.6Department of Electrical and Computer Engineering, University of Illinois, Urbana, Il 61801; Micro and Nanotechnology Laboratory, University of Illinois, Urbana, Il 61801. Electronic address: hyungsoo@illinois.edu.7Department of Anatomy, Inha University School of Medicine, Inchon, Korea; Inha Research Institute for Medical Sciences, Inha University School of Medicine, Inchon, Korea. Electronic address: jklee@inha.ac.kr.AbstractGelatin microspheres (GMSs) are widely used as drug carriers owing to their excellent biocompatibilities and toxicologically safe degradation products. The drug release profile is easily tailored by controlling the crosslinking density and surface to volume ratio, i.e., size, of the GMS. In this study, we employed GMSs, which are 25 μm in diameter and cross-linked with 0.03125% glutaraldehyde, to enable rapid initial- and a subsequent sustained release. Therapeutic potency of human recombinant osteopontin (rhOPN) with or without encapsulating into GMS was investigated after administrating them to rat stroke model (Sprague-Dawley; middle cerebral artery occlusion, MCAO). The administration of rhOPN/GMS (100 ng/100 ug) at 1 hr post-MCAO reduced the mean infarct volume by 81.8% of that of the untreated MCAO control and extended the therapeutic window at least to 12 hrs post-MCAO, demonstrating a markedly enhanced therapeutic potency for the use of OPN in the postischemic brain. SEM micrographs revealed that GMSs maintained the 3-D shape for more than 5 days in normal brain but were degraded rapidly in the postischemic brain presumably due to high levels of gelatinase induction. After encapsulation with GMS, the duration of OPN release was markedly extended; from the period of 2 days to 5 days in normal brain, and from 2 days to 4 days in the postischemic brain, which encompass the critical period for recovery processes, such as vascularization, and controlling inflammation. Together these results indicate that GMS-mediated drug delivery has a huge potent to battle for the hyperacute period in the postischemic brain.
- Acta biomaterialia.Acta Biomater.2014 Mar 4. pii: S1742-7061(14)00097-X. doi: 10.1016/j.actbio.2014.02.045. [Epub ahead of print]
- Gelatin microspheres (GMSs) are widely used as drug carriers owing to their excellent biocompatibilities and toxicologically safe degradation products. The drug release profile is easily tailored by controlling the crosslinking density and surface to volume ratio, i.e., size, of the GMS. In this stu
- PMID 24607857
Japanese Journal
- Single dose oral toxicity study of <i>Picrorhiza kurroa</i> rhizome extract in Wistar rats
- Fundamental Toxicological Sciences 3(1), 9-12, 2016
- NAID 130005120119
- A Simple and Rapid Method for Standard Preparation of Gas Phase Extract of Cigarette Smoke
- PLoS ONE 9(9), e107856, 2014-09-17
- NAID 120005496512
- A 4-week oral toxicity study of L-alanine in rats with a recovery period of 2 weeks
- Fundamental Toxicological Sciences 1(2), 63-72, 2014
- NAID 130005083336
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- Define toxicologically. toxicologically synonyms, toxicologically pronunciation, toxicologically translation, English dictionary definition of toxicologically. n. The study of the nature, effects, and detection of poisons and the treatment ...
- toxicologically, adverb toxicologist, noun Dictionary.com Unabridged Based on the Random House Dictionary, © Random House, Inc. 2016. Cite This Source Examples from the Web for toxicology Expand Contemporary Examples ...
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★リンクテーブル★
| リンク元 | 「中毒学的」「毒物学的」「toxicologic」 |
| 関連記事 | 「toxicological」 |
「中毒学的」
「毒物学的」
「toxicologic」
- adj.
- 毒物学的な、中毒学的な
「toxicological」
- adj.
- 中毒学的な、毒物学的な、中毒学の、毒物学の、毒性学の、毒科学の