English Journal

Severe multiple sclerosis reactivation under fingolimod 3 months after natalizumab withdrawal.

Daelman L, Maitrot A, Maarouf A, Chaunu MP, Papeix C, Tourbah A.Author information Department of Neurology, CHU de Reims, Reims, France.AbstractWe report the case of a woman with multiple sclerosis who developed a severe neurological condition following natalizumab (NZB) withdrawal and soon after fingolimod (FTY) initiation. FTY was started 3.5 months after a two-year NZB treatment. Fifteen days later, she suffered partial repetitive seizures followed by a tonicoclonic seizure. This was associated with attention difficulties and an increased asthenia. Brain MRI follow-up disclosed large demyelinating active lesions in favour of disease reactivation. This case suggests that FTY introduction may occur less than three months after NZB withdrawal.
Multiple sclerosis (Houndmills, Basingstoke, England).Mult Scler.2012 Nov;18(11):1647-9. doi: 10.1177/1352458512458009. Epub 2012 Aug 20.
We report the case of a woman with multiple sclerosis who developed a severe neurological condition following natalizumab (NZB) withdrawal and soon after fingolimod (FTY) initiation. FTY was started 3.5 months after a two-year NZB treatment. Fifteen days later, she suffered partial repetitive seizur
PMID 22907938

Seizures and hyponatremia related to ethcathinone and methylone poisoning.

Boulanger-Gobeil C, St-Onge M, Laliberté M, Auger PL.Author information Université Laval, Quebec, QC, Canada.AbstractINTRODUCTION: We report a case of ethcathinone and methylone poisoning with severe clinical toxicity. This is to our knowledge the first case reported in the medical toxicology literature.
Journal of medical toxicology : official journal of the American College of Medical Toxicology.J Med Toxicol.2012 Mar;8(1):59-61. doi: 10.1007/s13181-011-0159-1.
INTRODUCTION: We report a case of ethcathinone and methylone poisoning with severe clinical toxicity. This is to our knowledge the first case reported in the medical toxicology literature.CASE REPORT: A 22-year-old woman was brought to the emergency department following several episodes of tonicoclo
PMID 21755421

[Pseudostatus epilepticus: a severe complication of psychogenic nonepileptic seizures (PNES) in children].

Spitz MA, Vercueil L, Dubois-Teklali F.Author information Explorations fonctionnelles du système nerveux, CHU de Grenoble, BP 217, 38043 Grenoble cedex 09, France. MASpitz@chu-grenoble.frAbstractPsychogenic nonepileptic seizures are clinical events that mimic epileptic seizures but are not associated with electroencephalographic discharges. These seizures are seldom reported in children in the literature and could be misinterpreted as generalized tonicoclonic seizures. We report the case of a child, already treated for epilepsy, who presented at 8 years of age with several psychogenic seizures leading to pseudostatus epilepticus. After several hospitalizations, the diagnosis of pseudostatus was established on the basis of clinical semiology, lack of EEG abnormalities during the seizures, and a positive provocation maneuver, which elicited and blocked the manifestations. The clinical spectrum of psychogenic seizures is wide and it is particularly difficult to differentiate psychogenic seizures from epileptic seizures, especially when occurring in children, some of whom are already treated for epilepsy. Well-described clinical features can suggest the diagnosis of psychogenic seizure. It is important and necessary to make the diagnosis as soon as possible in order to rapidly begin appropriate treatment including psychotherapy. In fact, the long-term prognosis in children is better than in the adult population. Associated risk factors, such as anxiety as reported in the present case, have to be sought. Recognizing psychogenic seizures will thus avoid their fixation in the child's personality and the risk of inappropriate and escalating treatments leading to iatrogenic complications.
Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie.Arch Pediatr.2012 Jan;19(1):47-50. doi: 10.1016/j.arcped.2011.10.005. Epub 2011 Nov 18.
Psychogenic nonepileptic seizures are clinical events that mimic epileptic seizures but are not associated with electroencephalographic discharges. These seizures are seldom reported in children in the literature and could be misinterpreted as generalized tonicoclonic seizures. We report the case of
PMID 22100416