English Journal

Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test.

Kawaura K, Miki R, Urashima Y, Honda S, Shehata AM, Soeda F, Shirasaki T, Takahama K.SourceDepartment of Environmental and Molecular Health Sciences, Kumamoto University, Kumamoto 862-0973, Japan.
European journal of pharmacology." abstractLink="yes" alsec="jour" alterm="Eur J Pharmacol.2011 Jan 25;651(1-3):106-8. Epub 2010 Nov 27.
Several antidepressants have been used to treat severe pain in clinics. Recently, we reported that the centrally acting non-narcotic antitussive (cough suppressant drug), tipepidine produces an antidepressant-like effect in the forced swimming test, although the mechanism of action appears to be qui
PMID 21114989

Honda S, Kawaura K, Soeda F, Shirasaki T, Takahama K.SourceDepartment of Environmental and Molecular Health Sciences, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan.
Behavioural brain research." abstractLink="yes" alsec="jour" alterm="Behav Brain Res.2011 Jan 1;216(1):308-12. Epub 2010 Aug 14.
Our previous study revealed that centrally acting non-narcotic antitussives inhibited G-protein-coupled inwardly rectifying K(+) (GIRK) channel currents in brain neurons, and that the tipepidine antitussives had a novel antidepressive-like effect on rats. Furthermore, the antitussives revealed multi
PMID 20713091

Japanese Journal

前島徹,大沢孝,小林征雄,野田和夫
Chemical & pharmaceutical bulletin 40(2), 488-492, 1992-02-25
… Water-soluble drugs such as nicotinamide or isoniazid produced spherical beads with a smooth surface, whereas slightly water-soluble drugs such as tipepidine hibenzate or bisbentiamine produced beads of irregular shape and rough surfaces. …
NAID 110003629793