tindamax

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Tindamax

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Tinidazole

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/01/18 08:46:02」(JST)

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Tinidazole

Clinical data
Trade names	Fasigyn, Simplotan, Tindamax
AHFS/Drugs.com	Monograph
MedlinePlus	a604036
Pregnancy category	AU: B3 US: C (Risk not ruled out)
Routes of administration	Oral
ATC code	J01XD02 (WHO) P01AB02 (WHO) QP51AA02 (WHO)
Legal status
Legal status	AU: S4 (Prescription only) UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Protein binding	12%
Metabolism	Hepatic (CYP3A4)
Biological half-life	12–14 hours
Excretion	Urine (20–25%), faeces (12%)
Identifiers
IUPAC name 1-(2-ethylsulfonylethyl)-2-methyl-5-nitro-imidazole
CAS Number	19387-91-8 Y
PubChem CID	5479
DrugBank	DB00911 Y
ChemSpider	5279 Y
UNII	033KF7V46H
KEGG	D01426 Y
ChEMBL	CHEMBL1220 Y
NIAID ChemDB	007940
ECHA InfoCard	100.039.089
Chemical and physical data
Formula	C8H13N3O4S
Molar mass	247.273 g/mol
3D model (JSmol)	Interactive image
SMILES [O-][N+](=O)c1cnc(n1CCS(=O)(=O)CC)C
InChI InChI=1S/C8H13N3O4S/c1-3-16(14,15)5-4-10-7(2)9-6-8(10)11(12)13/h6H,3-5H2,1-2H3 Y Key:HJLSLZFTEKNLFI-UHFFFAOYSA-N Y
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Tinidazole is an anti-parasitic drug used against protozoan infections. It is widely known throughout Europe and the developing world as a treatment for a variety of amoebic and parasitic infections. It was developed in 1972 and is a prominent member of the nitroimidazole antibiotic class.

Tinidazole is marketed by Mission Pharmacal under the brand name Tindamax, by Pfizer under the names Fasigyn and Simplotan, and in some Asian countries as Sporinex.

Uses

A large body of clinical data exists to support use of tinidazole for infections from amoebae, giardia, and trichomonas, just like metronidazole. Tinidazole may be a therapeutic alternative in the setting of metronidazole tolerance. Tinidazole may also be used to treat a variety of other bacterial infections (e.g., as part of combination therapy for Helicobacter pylori eradication protocols).

Side effects

Drinking alcohol while taking tinidazole causes an unpleasant disulfiram-like reaction, which includes nausea, vomiting, headache, increased blood pressure, flushing, and shortness of breath.

Half-life

Elimination half-life is 13.2 ± 1.4 hours. Plasma half-life is 12 to 14 hours.

External links

• MedlinePlus Drug Information: Tinidazole
• Drug Bank Facts on Tinidazole

UpToDate Contents

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• 1. 細菌性膣炎 bacterial vaginosis
• 2. 抗原虫治療 antiprotozoal therapies
• 3. ジアルジア症の治療および予防 treatment and prevention of giardiasis
• 4. トリコモナス trichomoniasis
• 5. 赤痢アメーバによる腸菅アメーバ症 intestinal entamoeba histolytica amebiasis

English Journal

• Drug treatments for skin disease introduced in 2007.

• [No authors listed]
• Skin therapy letter.Skin Therapy Lett.2008 Mar;13(2):7-9.
• A comprehensive list of drug treatments for skin disease including: Adapalene Gel 0.3% (Differin(R)), Drospirenone/ Ethinyl Estradiol (Yaz(R)), Tretinoin 0.05% Gel (Anthralin(R)), Daptomycin for Injection (CUBICIN(R)), Retapamulin Ointment 1% (Altabax(R)), Tinidazole Tablets (Tindamax(R)), Ciclopiro
• PMID 18373042

• Spectroscopic analysis of the binding interaction between tinidazole and bovine serum albumin (BSA).

• Shi XY1, Cao H, Ren FL, Xu M.
• Chemistry & biodiversity.Chem Biodivers.2007 Dec;4(12):2780-90.
• PMID 18081088

• Tinidazole (Tindamax)--a new option for treatment of bacterial vaginosis.

• [No authors listed]
• The Medical letter on drugs and therapeutics.Med Lett Drugs Ther.2007 Sep 10;49(1269):73-4.
• PMID 17848905

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