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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/05/01 21:03:27」(JST)

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IUPAC definition

Property of a material (or substance) that induces and/or promotes
the formation of a thrombus.^[1]

Thrombogenicity refers to the tendency of a material in contact with the blood to produce a thrombus, or clot. It not only refers to fixed thrombi but also to emboli, thrombi which have become detached and travel through the bloodstream. Thrombogenicity can also encompass events such as the activation of immune pathways and the complement system. All materials are considered to be thrombogenic^{[citation needed]} with the exception of the normal state of endothelial cells which line blood vessels.^[2] Certain medical implants appear non-thrombogenic due to high flow rates of blood past the implant, but in reality all are thrombogenic to a degree. Various surface treatments are available to minimize these thrombogenic effects.

A thrombogenic implant will eventually be covered by a fibrous capsule, the thickness of this capsule can be considered one measure of thrombogenicity, and if extreme can lead to the failure of the implant.

References

^ "Terminology for biorelated polymers and applications (IUPAC Recommendations 2012)". Pure and Applied Chemistry 84 (2): 377–410. 2012. doi:10.1351/PAC-REC-10-12-04.
^ López JA, Chen J (2009). "Pathophysiology of venous thrombosis". Thromb Res 123 (Suppl 4): S30–4. doi:10.1016/S0049-3848(09)70140-9. PMID 19303501.

UpToDate Contents

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1. 冠動脈疾患患者における脂質低下薬の利益の機序 mechanisms of benefit of lipid lowering drugs in patients with coronary heart disease
2. 遺伝性血栓性素因を有する女性のための避妊カウンセリング contraceptive counseling for women with inherited thrombophilias
3. フィブラート系薬剤による脂質低下 lipid lowering with fibric acid derivatives
4. 外科的弁置換術における人工弁の選択 choice of prosthetic heart valve for surgical replacement
5. 人工心臓弁のある患者における抗血栓療法 antithrombotic therapy in patients with prosthetic heart valves

English Journal

Biocompatible and target specific hydrophobically modified glycol chitosan nanoparticles.

Yin W1, Li W2, Rubenstein DA3, Meng Y2.
Biointerphases.Biointerphases.2016 Dec 28;11(4):04B301. doi: 10.1116/1.4948265.
Cardiovascular disease is the leading cause of death in the United States. Atherosclerosis is a major cause for cardiovascular diseases. Drugs that treat atherosclerosis usually act nonspecifically. To enhance drug delivery specificity, the authors developed a hydrophobically modified glycol chitosa
PMID 27126597

Blood compatibility assessment of polymers used in drug eluting stent coatings.

Szott LM1, Irvin CA1, Trollsas M2, Hossainy S2, Ratner BD3.
Biointerphases.Biointerphases.2016 Jun 15;11(2):029806. doi: 10.1116/1.4944586.
Differences in thrombosis rates have been observed clinically between different drug eluting stents. Such differences have been attributed to numerous factors, including stent design, injury created by the catheter delivery system, coating application technologies, and the degree of thrombogenicity
PMID 27083991

Indices of dietary fat quality during midpregnancy is associated with gestational diabetes.

Barbieiri P1, Nunes JC2, Torres AG3, Nishimura RY1, Zuccolotto DC1, Crivellenti LC1, Franco LJ4, Sartorelli DS5.
Nutrition (Burbank, Los Angeles County, Calif.).Nutrition.2016 Jun;32(6):656-61. doi: 10.1016/j.nut.2015.12.002. Epub 2015 Dec 18.
OBJECTIVE: To investigate the relationship between gestational diabetes mellitus (GDM) and the usual intake of fatty acids and indices of dietary fat quality [the atherogenicity (AI) and thrombogenicity indices (TI), and the ratios of hypo-and hypercholesterolemic (hH), ∑n-3/∑n-6, and polyunsatu
PMID 26876000

Japanese Journal

Human Coronary Thrombus Formation Is Associated With Degree of Plaque Disruption and Expression of Tissue Factor and Hexokinase II

Okuyama Nozomi,Matsuda Shuntaro,Yamashita Atsushi,Moriguchi-Goto Sayaka,Sameshima Naoki,Iwakiri Takashi,Matsuura Yunosuke,Sato Yuichiro,Asada Yujiro
Circulation Journal advpub(0), 2015
… Background:Atherosclerotic plaque thrombogenicity is a critical factor that affects thrombus formation and the onset of acute myocardial infarction (AMI). … Inhibiting glycolysis enhanced TF expression in the macrophages partly via hypoxia inducible factor-1α.Conclusions:The degree of plaque disruption and expression of TF and HK-II appear to be important vascular factors for AMI onset, and polarized macrophages make a distinct contribution to thrombogenicity and glucose metabolism. …
NAID 130005097268

Efficacy and Limitations of Transarterial Acrylic Glue Embolization for Intracranial Dural Arteriovenous Fistulas

MIYAMOTO Naoko,NAITO Isao,SHIMIZU Tatsuya,YOSHIMOTO Yuhei
Neurologia medico-chirurgica advpub(0), 2015
… The benefits of glue embolization compared to Onyx embolization are high thrombogenicity, and relatively low risks of cranial nerve palsies and of excessive migration into the draining veins of high flow fistula. …
NAID 130004922310

Efficacy and Limitations of Transarterial Acrylic Glue Embolization for Intracranial Dural Arteriovenous Fistulas

MIYAMOTO Naoko,NAITO Isao,SHIMIZU Tatsuya,YOSHIMOTO Yuhei
Neurologia medico-chirurgica 55(2), 163-172, 2015
… The benefits of glue embolization compared to Onyx embolization are high thrombogenicity, and relatively low risks of cranial nerve palsies and of excessive migration into the draining veins of high flow fistula. …
NAID 130004922273