- 関
- megakaryocytopoiesis、thrombopoiesis、thrombopoietic
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/06/06 23:56:12」(JST)
[Wiki en表示]
Thrombopoiesis refers to the process of thrombocyte generation.[1][2] Thromobocytes are ligations of the cytoplasm from megakaryocytes. A single megakaryocyte can give rise to thousands of thrombocytes.
The term "thrombocytopoiesis" is sometimes used to emphasize the cellular nature.
Thrombopoietin stimulates megakaryopoiesis, the process of megakaryocyte maturation and differentiation. Thrombopoietin, upon release, binds to its receptor, c-mpl, found on megakaryocyte progenitor cells. Following binding, intracellular signalling leads to megakaryocyte growth, maturation, membrane stability, platelet granule formation and the demarcation of the cytoplasm into regions destined to fragment into mature platelets. These "proplatelet processes" further fragment into platelets. This last step of proplatelet process and platelet formation, in vitro, has been shown to be independent of thrombopoietin.
References
- ^ Thrombopoiesis at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ SCHULMAN I, PIERCE M, LUKENS A, CURRIMBHOY Z (July 1960). "Studies on thrombopoiesis. I. A factor in normal human plasma required for platelet production; chronic thrombocytopenia due to its deficiency". Blood 16: 943–57. PMID 14443744.
Myeloid physiology
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Hematopoiesis |
Myelopoiesis
(CFU-GEMM) |
CFU-GM |
- Granulopoiesis
- Myeloblast
- Promyelocyte
- Myelocyte
- Metamyelocyte
- Band cell
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MEP |
- Thrombopoiesis
- Megakaryoblast
- Promegakaryocyte
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- Erythropoiesis
- Proerythroblast
- Normoblast
- Reticulocyte
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General |
- Extramedullary hematopoiesis
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Hemostasis |
- Coagulation
- Clot retraction
- Platelet adhesiveness
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Other |
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UpToDate Contents
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English Journal
- Comparative analysis of human ex vivo-generated platelets vs megakaryocyte-generated platelets in mice: a cautionary tale.
- Wang Y1, Hayes V1, Jarocha D2, Sim X3, Harper DC4, Fuentes R1, Sullivan SK1, Gadue P3, Chou ST3, Torok-Storb BJ5, Marks MS6, French DL3, Poncz M3.
- Blood.Blood.2015 Jun 4;125(23):3627-36. doi: 10.1182/blood-2014-08-593053. Epub 2015 Apr 7.
- Thrombopoiesis is the process by which megakaryocytes release platelets that circulate as uniform small, disc-shaped anucleate cytoplasmic fragments with critical roles in hemostasis and related biology. The exact mechanism of thrombopoiesis and the maturation pathways of platelets released into the
- PMID 25852052
- Immature platelet fraction measurement is influenced by platelet size and is a useful parameter for discrimination of macrothrombocytopenia.
- Miyazaki K, Koike Y, Kunishima S, Ishii R, Danbara M, Horie R, Yatomi Y, Higashihara M.
- Hematology (Amsterdam, Netherlands).Hematology.2015 Jun 2. [Epub ahead of print]
- Background Reticulated platelets (RPs) as measured using flow cytometry are useful parameters of thrombopoiesis; however, difficulties remain with standardization between laboratories. On the other hand, immature platelet fraction (IPF) measurement, as determined using an automated hematology analyz
- PMID 26035037
- Loss of autophagy leads to failure in megakaryopoiesis, megakaryocyte differentiation, and thrombopoiesis in mice.
- Cao Y1, Cai J1, Zhang S1, Yuan N1, Li X1, Fang Y1, Song L1, Shang M1, Liu S1, Zhao W1, Hu S1, Wang J2.
- Experimental hematology.Exp Hematol.2015 Jun;43(6):488-94. doi: 10.1016/j.exphem.2015.01.001. Epub 2015 Jan 13.
- During hematopoiesis, megakaryopoiesis, megakaryocyte differentiation, and thrombopoiesis are regulated at multiple stages, which involve successive lineage commitment steps and proceed with polyploidization, maturation, and organized fragmentation of the cytoplasm, leading to the release of platele
- PMID 25591498
Japanese Journal
- Thrombopoietin-Producing Hepatocellular Carcinoma
- Mice lacking transcription factor NF-E2 provide in vivo validation of the proplatelet model of thrombocytopoiesis and show a platelet production defect that is intrinsic to megakaryocytes
★リンクテーブル★
[★]
- 英
- thrombocytopoiesis, thrombopoiesis
- 同
- 血小板産生、血小板新生、血小板形成、血小板造血
- 関
- 血小板キネティクス
[★]
- 英
- thrombopoiesis、thrombocytopoiesis、thrombopoietic
- 関
- 巨核球形成
[★]
- 関
- megakaryopoiesis、thrombocytopoiesis、thrombopoiesis
[★]
- 関
- thrombocytopoiesis、thrombopoiesis