チオ三リン酸エステル、チオ三リン酸
English Journal
- Enzymatic Synthesis of Modified Oligonucleotides by PEAR Using Phusion and KOD DNA Polymerases.
- Wang X1, Zhang J, Li Y, Chen G, Wang X.
- Nucleic acid therapeutics.Nucleic Acid Ther.2014 Dec 17. [Epub ahead of print]
- Antisense synthetic oligonucleotides have been developed as potential gene-targeted therapeutics. We previously reported polymerase-endonuclease amplification reaction (PEAR) for amplification of natural and 5'-O-(1-thiotriphosphate) (S)-modified oligonucleotides. Here, we extended the PEAR techniqu
- PMID 25517220
- Ectonucleotide pyrophosphatase/phosphodiesterase activity in Neuro-2a neuroblastoma cells: changes in expression associated with neuronal differentiation.
- Gómez-Villafuertes R1, Pintor J, Miras-Portugal MT, Gualix J.
- Journal of neurochemistry.J Neurochem.2014 Nov;131(3):290-302. doi: 10.1111/jnc.12794. Epub 2014 Jul 10.
- Neuro-2a (N2a) neuroblastoma cells display an ectoenzymatic hydrolytic activity capable of degrading diadenosine polyphosphates. The Apn A-cleaving activity has been analysed with the use of the fluorogenic compound BODIPY FL guanosine 5'-O-(3-thiotriphosphate) thioester. Hydrolysis of this dinucleo
- PMID 24947519
- Design, synthesis, and biological evaluation of (3R)-1,2,3,4-tetrahydro-7-hydroxy-N-[(1S)-1-[[(3R,4R)-4-(3-hydroxyphenyl)-3,4-dimethyl-1-piperidinyl]methyl]-2-methylpropyl]-3-isoquinolinecarboxamide (JDTic) analogues: in vitro pharmacology and ADME profile.
- Kormos CM1, Gichinga MG, Maitra R, Runyon SP, Thomas JB, Brieaddy LE, Mascarella SW, Navarro HA, Carroll FI.
- Journal of medicinal chemistry.J Med Chem.2014 Sep 11;57(17):7367-81. doi: 10.1021/jm5008177. Epub 2014 Aug 25.
- JDTic analogues 4-15 which have the hydroxyl groups replaced with other groups were synthesized and their in vitro efficacy at the μ, δ, and κ opioid receptors determined and compared to JDTic using [(35)S]GTPγS assays. Compounds 4, 5, 6, 13, 14, and 15 had Ke = 0.024, 0.01, 0.039, 0.02, 0.11, a
- PMID 25133923
Japanese Journal
- Contribution of Active and Inactive States of the Human 5-HT_<4d> Receptor to the Functional Activities of 5-HT_4-Receptor Agonists
- Mikami Tadayoshi,Sugimoto Hiromi,Naganeo Rie [他],OHMI Takashi,SAITO Toshiyuki,EDA Hiroyuki
- Journal of pharmacological sciences 107(3), 251-259, 2008-07-20
- … Additionally, the number of [3H]5-HT binding sites decreased in the presence of guanosine-5'-O-(3-thiotriphosphate) (GTPγS), but the number of [3H]GR113,808 sites did not change. …
- NAID 10024321238
- Roles of the HSP70-Subunit in a Eukaryotic Multi-Site-Specific Endonuclease, Endo. SceI : Autophosphorylation and Heat Stability
- , ,
- Bioscience, biotechnology, and biochemistry 68(12), 2557-2564, 2004-12-23
- … ATP, adenosine 5′-<I>O</I>-(3-thiotriphosphate) (ATP-γ-S), and ADP not only protected the endonucleolytic activity against heat inactivation in the presence of Ca<SUP>2+</SUP> …
- NAID 130000030886
- Melatonin Binding Sites in the Brain of European Sea Bass(Dicentrarchus labrax)(Endocrinology)
- Bayarri Maria Jose,Garcia-Allegue Rosa,Munoz-Cueto Jose Antonio [他],Madrid Juan Antonio,Tabata Mitsuo,Sanchez-Vazquez F. Javier,Iigo Masayuki
- Zoological science 21(4), 427-434, 2004-04-25
- … Characteristics, day-night changes, guanosine 5'-O-(3-thiotriphosphate) (GTP-γS) modulation, and localization of melatonin binding sites in the brain of a marine teleost, European sea bass Decentrarchus labrax, were studied by radioreceptor assay using 2-[^<125>I]iodomelatonin as a radioligand. …
- NAID 110006282414
Related Links
- Sigma-Aldrich offers Sigma-Adenosine 5′-[γ-thio]triphosphate tetralithium salt for your research needs. Find product specific information, including CAS, MSDS, protocols and references.
- Sigma-Aldrich offers Sigma-Guanosine 5′-[γ-thio]triphosphate tetralithium salt for your research needs. Find product specific information, including CAS, MSDS, protocols and references.
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