チオプロペラジン
- 関
- thioproperazine mesilate
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/02/06 04:54:37」(JST)
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Thioproperazine
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Names |
IUPAC name
N,N-dimethyl-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine-2-sulfonamide
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Identifiers |
CAS Number
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316-81-4 Y |
ChEBI |
CHEBI:59120 Y |
ChEMBL |
ChEMBL609109 Y |
ChemSpider |
9058 Y |
DrugBank |
DB01622 Y |
Jmol interactive 3D |
Image |
KEGG |
D08585 Y |
PubChem |
9429 |
UNII |
YJ050AQ56X Y |
InChI
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InChI=1S/C22H30N4O2S2/c1-23(2)30(27,28)18-9-10-22-20(17-18)26(19-7-4-5-8-21(19)29-22)12-6-11-25-15-13-24(3)14-16-25/h4-5,7-10,17H,6,11-16H2,1-3H3 Y
Key: VZYCZNZBPPHOFY-UHFFFAOYSA-N Y
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InChI=1/C22H30N4O2S2/c1-23(2)30(27,28)18-9-10-22-20(17-18)26(19-7-4-5-8-21(19)29-22)12-6-11-25-15-13-24(3)14-16-25/h4-5,7-10,17H,6,11-16H2,1-3H3
Key: VZYCZNZBPPHOFY-UHFFFAOYAJ
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SMILES
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CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)S(=O)(=O)N©C
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Properties |
Chemical formula
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C22H30N4O2S2 |
Molar mass |
446.6292 g/mol |
Pharmacology |
ATC code |
N05AB08 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Y verify (what is YN ?) |
Infobox references |
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Thioproperazine is an antipsychotic.[citation needed]
Antipsychotics (neuroleptics) (N05A)
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Typical |
- Benzamides
- Levosulpiride
- Sulpiride
- Veralipride‡
- Butyrophenones
- Aceperone
- Azaperone
- Benperidol
- Bromperidol
- Droperidol
- Fluanisone
- Haloperidol#
- Lenperone
- Moperone
- Pipamperone
- Spiperone
- Timiperone
- Trifluperidol
- Diphenylbutylpiperidines
- Clopimozide
- Fluspirilene
- Penfluridol
- Pimozide
- Phenothiazines
- Acepromazine
- Acetophenazine
- Butaperazine
- Carphenazine
- Chloracizine
- Chlorproethazine
- Chlorpromazine
- Cyamemazine
- Dixyrazine
- Fluacizine
- Fluphenazine
- Levomepromazine/Methotrimeprazine
- Mesoridazine
- Perazine
- Periciazine
- Perphenazine
- Perphenazine 4-aminobutyrate
- Piperacetazine
- Pipotiazine
- Prochlorperazine
- Promazine
- Promethazine
- Propiomazine
- Sulforidazine
- Thiethylperazine
- Thiopropazate
- Thioproperazine
- Thioridazine
- Trifluoperazine
- Triflupromazine
- Thioxanthenes
- Chlorprothixene
- Clopenthixol
- Clothixamide
- Flupentixol
- Fluprothixene
- Piflutixol
- Teflutixol
- Thiothixene
- Zuclopenthixol
- Tricyclics
- Fluotracen
- Loxapine
- Trimipramine
- Others
- Butaclamol
- Prothipendyl
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Atypical |
- Benzamides
- Amisulpride
- Nemonapride
- Remoxipride‡
- Sultopride
- Tiapride
- Butyrophenones
- Cinuperone
- Melperone
- Setoperone
- Benzo(iso)oxazolepiperidines
- Iloperidone
- Ocaperidone§
- Paliperidone
- Risperidone#
- Benzo(iso)thiazolepiperazines
- Lurasidone
- Perospirone
- Revospirone§
- Tiospirone§
- Ziprasidone
- Diphenylbutylpiperazines
- Amperozide
- Phenylpiperazines
- Aripiprazole
- Aripiprazole lauroxil
- Bifeprunox§
- Brexpiprazole
- Cariprazine
- Tricyclics
- Amoxapine
- Asenapine
- Carpipramine
- Clocapramine
- Clorotepine
- Clotiapine
- Clozapine#
- Fluperlapine
- Gevotroline
- Metitepine
- Mosapramine
- Olanzapine
- Quetiapine
- Tenilapine
- Zotepine
- Others
- Blonanserin
- ITI-007†
- Molindone
- Pimavanserin
- RP5063†
- Sertindole
- Zicronapine§
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Others |
- Azacyclonol
- Cannabidiol
- Oxypertine
- Reserpine
- Tetrabenazine
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Index of psychology and psychiatry
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Description |
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Disorders |
- Mental and behavioral
- Mood
- Developmental
- pervasive
- dyslexia and specific
- Substance-related
- Emotional and behavioral disorders
- Symptoms and signs
- Evaluation and testing
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Treatment |
- Psychotherapy
- Drugs
- depression
- antipsychotics
- anxiety
- dementia
- hypnotics and sedatives
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English Journal
- [Phenothiazines are slowly oxidizable substrates of horseradish peroxidase].
- Rogozhina TV, Rogozhin VV.
- Biomedit͡sinskai͡a khimii͡a.Biomed Khim.2011 Sep-Oct;57(5):544-53.
- Reactions of peroxidase oxidation of triftazine and thioproperazine have been investigated in the presence of horseradish peroxidase using steady state kinetic methods. It has been shown that phenothiazines are slowly oxidizable substrates for horseradish peroxidase. k(cat) and K(m) values have been
- PMID 22629605
- Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography.
- Tanaka E1, Nakamura T, Terada M, Shinozuka T, Hashimoto C, Kurihara K, Honda K.
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2007 Jul 1;854(1-2):116-20. Epub 2007 Apr 13.
- A high-performance liquid chromatographic method has been developed for the simultaneous analysis of the 12 phenothiazines (chlorpromazine, fluphenazine, levomepromazine, perazine, perphenazine, prochlorperazine, profenamine, promethazine, propericiazine, thioproperazine, thioridazine and trifluoper
- PMID 17459789
- Analysis of phenothiazines in human body fluids using disk solid-phase extraction and liquid chromatography.
- Marumo A1, Kumazawa T, Lee XP, Fujimaki K, Kuriki A, Hasegawa C, Sato K, Seno H, Suzuki O.
- Journal of AOAC International.J AOAC Int.2005 Nov-Dec;88(6):1655-60.
- Seven phenothiazine derivatives, perazine, perphenazine, prochlorperazine, propericiazine, thioproperazine, trifluoperazine, and flupentixol, have been found to be extractable from human plasma and urine samples using disk solid-phase extraction (SPE) with an Empore C18 cartridge. Human plasma and u
- PMID 16526447
Japanese Journal
- Simple and simultaneous determination for twelve phenothiazines in human serum by reversed-phase high-performance liquid chromatography
- Tanaka Einosuke,Nakamura Takako,Terada Masaru,Shinozuka Tatsuo,Hashimoto Chikako,Kurihara Katsuyoshi,Honda Katsuya,田中 榮之介
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 854(1), 116-120, 2007-07-01
- … A high-performance liquid chromatographic method has been developed for the simultaneous analysis of the 12 phenothiazines (chlorpromazine, fluphenazine, levomepromazine, perazine, perphenazine, prochlorperazine, profenamine, promethazine, propericiazine, thioproperazine, thioridazine and trifluoperazine) in human serum using HPLC/UV. …
- NAID 10025805017
- 表面電離検出ガスクロマトグラフィーによる血中フェノチアジン系薬物の高感度検出
- 服部 秀樹,山本 伸一,山田 高路,鈴木 修
- 1991-05-25
- … The sensitivity of GC-SID was highest with trimeprazine and levomepromazine and lowest with thiethylperazine and thioproperazine containing sulfur residues in their structurs. …
- NAID 120005313993
- 合成高分子化合物と医薬品との相互作用に関する研究(第2報) : スチレン無水マレイン酸共重合体とピラゾロン誘導体およびフェノチアジン誘導体との相互作用
- 島 和弘 [他],溝尻 顕爾,山本 隆一
- 藥學雜誌 90(4), 469-474, 1970-04-25
- … The degree of binding of SMA with antipyrine, aminopyrine, aminopropylone, chlorpromazine, promethazine, levomepromazine, propericiazine, prochlorperazine and thioproperazine was evaluated by the equilibrium distribution method. …
- NAID 110003654397
Related Links
- Consumer information about the medication THIOPROPERAZINE - ORAL , includes side effects, drug interactions, recommended dosages, and storage information. Read more about the prescription drug THIOPROPERAZINE ...
- Structure, properties, spectra, suppliers and links for: Thioproperazine. ... Predicted data is generated using the US Environmental Protection Agency’s EPISuite , for more information see their website. Log Octanol-Water Partition ...
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- 英
- thioproperazine、thioproperazine mesilate
- 関
- メシル酸チオプロペラジン
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- 関
- thioproperazine