English Journal

Rhenium and technetium tricarbonyl, {M(CO)3} (+) (M = Tc, Re), binding to mammalian metallothioneins: new insights into chemical and radiopharmaceutical implications.

Lecina J1, Palacios Ò, Atrian S, Capdevila M, Suades J.
Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry.J Biol Inorg Chem.2015 Apr;20(3):465-74. doi: 10.1007/s00775-014-1226-2. Epub 2014 Dec 16.
This paper deals with the binding of the four mammalian metallothioneins (MTs) to the organometallic metal fragment {fac-M(CO)3}(+) (M = (99)Tc, Re), which is highly promising for the preparation of second-generation radiopharmaceuticals. The study of the transmetallation reaction between zinc and r
PMID 25511253

Chemically and biologically harmless versus harmful ferritin/copper-metallothionein couples.

Carmona F1, Mendoza D, Kord S, Asperti M, Arosio P, Atrian S, Capdevila M, Dominguez-Vera JM.
Chemistry (Weinheim an der Bergstrasse, Germany).Chemistry.2015 Jan 7;21(2):808-13. doi: 10.1002/chem.201404660. Epub 2014 Nov 4.
The simultaneous measurement of the decrease of available Fe(II) ions and the increase of available Fe(III) ions allowed the analysis of the ferroxidase activity of two distinct apoferritins. Although recombinant human apoferritin (HuFtH) rapidly oxidizes Fe(II) to Fe(III) , this iron is not properl
PMID 25370199

Cantareus aspersus metallothionein metal binding abilities: the unspecific CaCd/CuMT isoform provides hints about the metal preference determinants in metallothioneins.

Pérez-Rafael S1, Monteiro F2, Dallinger R3, Atrian S2, Palacios O4, Capdevila M1.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Sep;1844(9):1694-707. doi: 10.1016/j.bbapap.2014.06.018. Epub 2014 Jun 28.
In Proteomics, gene/protein families including both specialized and non-specialized paralogs are an invaluable tool to study the evolution of structure/function relationships in proteins. Metallothioneins (MTs) of the pulmonate gastropod molluscs (snails) offer one of the best materials to study the
PMID 24982030