English Journal
- A pitcher-and-catcher mechanism drives endogenous substrate isomerization by a dehydrogenase in kynurenine metabolism.
- Yang Y1, Davis I1, Ha U2, Wang Y1, Shin I1, Liu A3.
- The Journal of biological chemistry.J Biol Chem.2016 Nov 3. pii: jbc.M116.759712. [Epub ahead of print]
- Aldehyde dehydrogenase typically perform oxidation of aldehydes to their corresponding carboxylic acid while reducing NAD(P)+ to NAD(P)H via covalent catalysis mediated by an active-site cysteine residue. One member of this superfamily, the enzyme 2-aminomuconate-6-semialdehyde dehydrogenase (AMSDH)
- PMID 27810899
- Reversible, partial inactivation of plant betaine aldehyde dehydrogenase by betaine aldehyde: mechanism and possible physiological implications.
- Zárate-Romero A1, Murillo-Melo DS1, Mújica-Jiménez C1, Montiel C1, Muñoz-Clares RA2.
- The Biochemical journal.Biochem J.2016 Apr 1;473(7):873-85. doi: 10.1042/BJ20151084. Epub 2016 Jan 20.
- In plants, the last step in the biosynthesis of the osmoprotectant glycine betaine (GB) is the NAD(+)-dependent oxidation of betaine aldehyde (BAL) catalysed by some aldehyde dehydrogenase (ALDH) 10 enzymes that exhibit betaine aldehyde dehydrogenase (BADH) activity. Given the irreversibility of the
- PMID 26792760
- S-Ribosylhomocysteine analogs containing a [4-thio]ribose ring.
- Sobczak AJ1, Chbib C1, Wnuk SF2.
- Carbohydrate research.Carbohydr Res.2015 Oct 13;415:39-47. doi: 10.1016/j.carres.2015.07.005. Epub 2015 Jul 23.
- The [4-thio]-S-ribosylhomocysteine (SRH) analogs containing substitution of a sulfur atom for the endocyclic oxygen were synthesized by coupling of the 4-thioribose substrates with a thiolate generated from the protected homocysteine. Coupling of the protected 1-deoxy-5-O-mesyl-S-oxo-4-thio-D-ribofu
- PMID 26279525
Japanese Journal
- Identification of Metabolites of KE-298, a New Antirheumatic Drug, and Its Physiological Properties in Rats
- Biological & pharmaceutical bulletin 19(3), 424-429, 1996-03-15
- NAID 110003641187
- The reaction of the soybean cotyledon mitochondrial cyanide-resistant alternative oxidase with sulfhydryl reagents suggests that α-keto acid activation involves the formation of a thiohemiacetal.
- J. Biol. Chem. 271, 25019-25026, 1996
- NAID 80009288559
- Site-Directed Mutagenesis Shows That the Conserved Cysteine Residues of Histidinol Dehydrogenase Are Not Essential for Catalysis.
- The Journal of Biochemistry 114(6), 856-861, 1993
- NAID 130003417532
Related Links
- Aldehyde dehydrogenases typically contain an active-site cysteine, which is generally thought to serve two functions: (1) to form a thiohemiacetal that anchors the substrate and (2) to activate the C-1 carbon for hydride transfer. Two mechanisms are reasonable (Scheme 3.25).
- thiohemiacetal (plural thiohemiacetals) (chemistry) any compound, of general formula R 2 C (SR')OH, R 2 C (OR')SH or R 2 C (SR')SH, derived from a hemiacetal by replacing oxygen with sulfur
- THIOHEMIACETAL. Discover> THIOHEMIACETAL. 3DPX-004693X-RAY STRUCTURE OF THE C-TERMINAL ULP1... rlevymyers. SUMO HYDROLASE, UBIQUITIN-LIKE PROTEASE 1, SMT3 HYDROLASE DESUMOYLATING ENZYME, CYSTEINE PROTEASE, SUMO PROCESSING ENZYME, SMT3 PROCESSING ENZYME, NABH4, THIOHEMIACETAL, COVALENT PROTEASE ADDUCT, HYDROLASE. Discover 3D Prints.
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