WordNet

a sedative and hypnotic drug; withdrawn from sale after discovered to cause severe birth defects because it inhibits angiogenesis

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サリドマイド(鎮静・睡眠薬)

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1. リウマチ性疾患の男性患者の性腺機能と催奇形性に抗炎症薬や免疫抑制剤が及ぼす影響effects of antiinflammatory and immunosuppressive drugs on gonadal function and teratogenicity in men with rheumatic diseases [show details]
…cycle of spermatogenesis before attempting conception. Thalidomide – Given the high rate of teratogenicity after maternal exposure to thalidomide and the presence of the drug in the semen of men who have …
2. 先天異常：原因birth defects causes [show details]
… for uterine cervix ripening and to induce labor . Some teratogens act within a narrow window. As an example, the teratogenic effect of thalidomide for limb defects is limited to 21 to 36 days postconception …
3. 難治性円板状ループスおよび亜急性皮膚ループスのマネージメントmanagement of refractory discoid lupus and subacute cutaneous lupus [show details]
…monitoring must occur with the use of thalidomide. The most well-known and most serious toxicity of thalidomide is teratogenicity . In the United States, thalidomide can only be prescribed through a Risk …
4. 皮膚サルコイドーシス：マネージメントcutaneous sarcoidosis management [show details]
… available for evaluation after three months of thalidomide, two had complete responses and eight had lesser degrees of improvement. Thalidomide is teratogenic. In the United States, patient and provider …
5. 硬化性粘液水腫scleromyxedema [show details]
… response to thalidomide is achieved, the lowest dose effective for maintaining improvement is used for maintenance therapy. Teratogenicity and peripheral neuropathy are side effects of thalidomide that can …

English Journal

Thalidomide embryopathy: Follow-up of cases born between 1959 and 2010.

Kowalski TW1,2, Sanseverino MT1,2,3, Schuler-Faccini L1,2,3, Vianna FS1,2,3,4.
Birth defects research. Part A, Clinical and molecular teratology.Birth Defects Res A Clin Mol Teratol.2015 Sep;103(9):794-803. doi: 10.1002/bdra.23376. Epub 2015 Jun 4.
BACKGROUND: Thalidomide is a known teratogen and it is estimated that more than ten thousand babies were affected by thalidomide embryopathy (TE), which is characterized mainly by limb defects, but can involve many organs and systems. Most people with TE were only evaluated at birth and it is not we
PMID 26043318

Multicenter investigation of lifestyle-related diseases and visceral disorders in thalidomide embryopathy at around 50 years of age.

Shiga T1, Shimbo T2, Yoshizawa A3.
Birth defects research. Part A, Clinical and molecular teratology.Birth Defects Res A Clin Mol Teratol.2015 Sep;103(9):787-93. doi: 10.1002/bdra.23363. Epub 2015 Jun 2.
BACKGROUND: In utero exposure to thalidomide causes a wide range of birth defects, including phocomelia, hearing loss and visceral disorders, known as thalidomide embryopathy (TE). Fifty years after the first report of TE, we conducted the first cross-sectional multicenter study to investigate the d
PMID 26033770

Transcriptomic changes in mouse embryonic stem cells exposed to thalidomide during spontaneous differentiation.

Gao X1, Sprando RL1, Yourick JJ1.
Data in brief.Data Brief.2015 Jun 3;4:199-202. doi: 10.1016/j.dib.2015.05.014. eCollection 2015.
Thalidomide is a potent developmental toxicant that induces a range of birth defects, notably severe limb malformations. To unravel the molecular mechanisms underpinning the teratogenic effects of thalidomide, we used microarrays to study transcriptomic changes induced by thalidomide in an in vitro
PMID 26217789

Japanese Journal

サリドマイド催奇性の原因因子の発見から創薬への展開

半田宏,伊藤拓水,安藤秀樹
Organ Biology 21(2), 134-140, 2014
… Half a century ago, the sedative thalidomide caused one of the worst notorious drug disasters in history, with more than 10,000 babies born with deformities. … Recently new thalidomide derivatives called immunomodulatory drugs (IMiDs) have been developed. … The mechanism by which IMiDs including thalidomide induce birth defects and therapeutic effects was a long-standing question. …
NAID 130004715794

サリドマイド胎芽病者の50年

栢森良二
The Japanese Journal of Rehabilitation Medicine 50(12), 957-961, 2013
… Thalidomide embryopathy resulted in babies born with deformities such as phocomelia after their mothers took only a few tablets of thalidomide drug during 36 to 56 days after their last menstrual periods. … There are two thalidomide embryopathy groups depending upon whether their hypoplasia is in the limbs or the auditory organs. … Fifty years after the thalidomide scandal, the drug is still in use. …
NAID 130003393543