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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/19 19:08:39」(JST)

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Technetium (^99mTc) tetrofosmin is a drug used in nuclear medicine cardiac imaging. It is sold under the brand name Myoview (GE Healthcare). The radioisotope, technetium-99m, is chelated by two 1,2-bis[di-(2-ethoxyethyl)phosphino]ethane ligands which belong to the group of diphosphines and which are referred to as tetrofosmin.^[1]^[2]

Tc-99m tetrofosmin is rapidly taken up by myocardial tissue and reaches its maximum level in approximately 5 minutes. About 66% of the total injected dose is excreted within 48 hours after injection (40% urine, 26% feces). Tc-99m tetrofosmin is indicated for use in scintigraphic imaging of the myocardium under stress and rest conditions. It is used to determine areas of reversible ischemia and infarcted tissue in the heart. It is also indicated to detect changes in perfusion induced by pharmacologic stress (adenosine, lexiscan, dobutamine or persantine) in patients with coronary artery disease. Its third indication is to assess left ventricular function (ejection fraction) in patients thought to have heart disease. No contraindications are known for use of Tc-99m tetrofosmin, but care should be taken to constantly monitor the cardiac function in patients with known or suspected coronary artery disease. Patients should be encouraged to void their bladders as soon as the images are gathered, and as often as possible after the tests to decrease their radiation doses, since the majority of elimination is renal. The recommended dose of Tc-99m tetrofosmin is between 5 and 33 millicuries (185-1221 megabecquerels). For a two-dose stress/rest dosing, the typical dose is normally a 10 mCi dose, followed one to four hours later by a dose of 30 mCi. Imaging normally begins 15 minutes following injection.^[3]

References

^ Kelly, JD; Alan M. Forster AM; Higley B et al. (February 1993). "Technetium-99m-Tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging". Journal of Nuclear Medicine 34 (2): 222–227. PMID 8429340.
^ Elhendy, A; Schinkel AF et al. (December 2005). "Risk stratification of patients with angina pectoris by stress 99mTc-tetrofosmin myocardial perfusion imaging". Journal of Nuclear Medicine 46 (12): 2003–2008. PMID 16330563.
^ Myoview package insert. Arlington Heights, IL: GE Healthcare, 2006, Aug.

External links

Myoview Prescribing Information Page

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1. 冠動脈疾患の核イメージングによる心筋生存能の評価 assessment of myocardial viability by nuclear imaging in coronary heart disease
2. 非ST上昇型急性冠症候群が疑われる患者の評価のための緊急安静時放射性核種心筋血流
イメージング acute rest radionuclide myocardial perfusion imaging for the evaluation of suspected non st elevation acute coronary syndrome
3. 心筋環流製の基本特性 basic properties of myocardial perfusion agents
4. 治療を受けた非ST上昇型急性冠症候群患者の退院前の重症度分類における核種心筋血流
イメージング radionuclide myocardial perfusion imaging in predischarge risk stratification of medically treated patients with non st elevation acute coronary syndrome
5. 冠動脈疾患の診断および予後における運動負荷放射性核種心筋血流イメージング exercise radionuclide myocardial perfusion imaging in the diagnosis and prognosis of coronary heart disease

English Journal

Prognostic significance of 123I-mIBG SPECT myocardial imaging in heart failure: differences between patients with ischaemic and non-ischaemic heart failure.

Clements IP1, Kelkar AA2, Garcia EV3, Butler J4, Chen J3, Folks R3, Jacobson AF5.
European heart journal cardiovascular Imaging.Eur Heart J Cardiovasc Imaging.2016 Apr;17(4):384-90. doi: 10.1093/ehjci/jev295. Epub 2015 Nov 20.
AIMS: The purpose of this study was to examine the prognostic significance of uptake patterns on quantitative myocardial (123)I-mIBG and (99m)Tc-tetrofosmin SPECT imaging in heart failure (HF) subjects and to assess the differences between patients with ischaemic and non-ischaemic HF.METHODS AND RES
PMID 26588983

Detection of perfusion abnormalities in patients with permanent pacemakers on stress-rest 99mTc-tetrofosmin myocardial perfusion single-photon emission computed tomography: comparison between right ventricular apex and right ventricular outflow tract pacing.

Das KJ1, Patel CD, Sharma G, Naik N, Singh H.
Nuclear medicine communications.Nucl Med Commun.2016 Apr;37(4):406-11. doi: 10.1097/MNM.0000000000000472.
OBJECTIVE: The aim of the study was to compare the myocardial perfusion defects in patients with right ventricular outflow tract (RVOT) and right ventricular apex (RVA) pacing on stress-rest Tc-tetrofosmin myocardial perfusion single-photon emission computed tomography.PATIENTS AND METHODS: A total
PMID 26730654

Reversible mycordial perfusion defects in patients not suffering from obstructive epicardial coronary artery disease as assessed by coronary angiography: a review of the literature.

VAN DE Wiele C1, Rimbu A, Belhocine T, DE Spiegeleer B, Sathekge M, Maes A.
The quarterly journal of nuclear medicine and molecular imaging : official publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of...Q J Nucl Med Mol Imaging.2016 Mar 23. [Epub ahead of print]
In approximately 10-30% of patients presenting with angina complaints, normal or non- obstructive coronary arteries are found on angiography. In this review paper, available literature on the underlying pathophysiological substrate explaining these discrepancies is reviewed. Both histological studie
PMID 27007665

Japanese Journal

Combined Supine and Prone Myocardial Perfusion Single-Photon Emission Computed Tomography With a Cadmium Zinc Telluride Camera for Detection of Coronary Artery Disease

Nishiyama Yoshiko,Miyagawa Masao,Kawaguchi Naoto,Nakamura Masashi,Kido Tomoyuki,Kurata Akira,Kido Teruhito,Ogimoto Akiyoshi,Higaki Jitsuo,Mochizuki Teruhito
Circulation Journal, 2014
… Methods and Results: A total of 276 consecutive patients with suspected/known coronary artery disease (CAD) who underwent single-day 99mTc-tetrofosmin or 99mTc-sestamibi stress/rest CZT SPECT, were enrolled in the study. …
NAID 130003391083

Assessment of Left Ventricular Systolic and Diastolic Function Using ECG-Gated Technetium-99m Tetrofosmin Myocardial Perfusion SPECT:Comparison With Ultrasound Echocardiography

Mizunobu Mayumi,Sakai Jun,Sasao Hisataka,Murai Hiroshi,Fujiwara Hidetoshi
International Heart Journal 54(4), 212-215, 2013
… On the other hand, electrocardiography (ECG)-gated technetium (Tc) -99m tetrofosmin single-photon emission computed tomography (SPECT) has been reported to be a useful method for evaluation of LV function. … The objective of this study was to examine the usefulness of ECG-gated Tc-99m tetrofosmin SPECT in terms of estimation of cardiac diastolic function. …
NAID 130003364472

Comparison of Myocardial Perfusion Imaging Between the New High-Speed Gamma Camera and the Standard Anger Camera

Tanaka Hirokazu,Chikamori Taishiro,Hida Satoshi,Uchida Kenji,Igarashi Yuko,Yokoyama Tsuyoshi,Takahashi Masaki,Shiba Chie,Yoshimura Mana,Tokuuye Koichi,Yamashina Akira
Circulation Journal 77(4), 1009-1017, 2013
… Methods and Results: The study group consisted of 150 consecutive patients who underwent a 1-day stress-rest 99mTc-sestamibi or tetrofosmin imaging protocol. …
NAID 130002491255

「テトロホスミン」

Technetium (^99mTc) tetrofosmin
Clinical data
Routes of; administration	Intravenous
Pharmacokinetic data
Bioavailability	N/A
Identifiers
CAS Registry Number	127455-27-0 ; 127502-06-1 (tetrofosmin)
ATC code	V09GA02
Chemical data
Formula	C36H80O10P4Tc
Molecular mass	895.813 g/mol
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　　[★]

英: tetrofosmin
関: テトロフォスミン

「テトロフォスミン」

　　[★]

英: tetrofosmin
関: テトロホスミン

「99mTc-tetrofosmin」

　　[★]

関: Technetium-99m tetrofosmin, 99mTc-Tetrofosmin

[1] Kelly, JD; Alan M. Forster AM; Higley B et al. (February 1993). "Technetium-99m-Tetrofosmin as a new radiopharmaceutical for myocardial perfusion imaging". Journal of Nuclear Medicine 34 (2): 222–227. PMID 8429340.

[Elhendy-2] Elhendy, A; Schinkel AF et al. (December 2005). "Risk stratification of patients with angina pectoris by stress 99mTc-tetrofosmin myocardial perfusion imaging". Journal of Nuclear Medicine 46 (12): 2003–2008. PMID 16330563.

[3] Myoview package insert. Arlington Heights, IL: GE Healthcare, 2006, Aug.

リンク元	「テトロホスミン」「テトロフォスミン」
拡張検索	「99mTc-tetrofosmin」

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tetrofosmin