Design of new drugs for the treatment of Alzheimer's disease based on tacrine structure.
de Aquino RA, Modolo LV, Alves RB, de Fatima A.SourceGrupo de Estudos em Quimica Organica e Biologica (GEQOB), Departamento de Quimica, ICEx, Universidade Federal de Minas Gerais, CEP 31270-901, Belo Horizonte, MG, Brazil. adefatima@qui.ufmg.br.
Current drug targets.Curr Drug Targets.2013 Mar 1;14(3):378-97.
Tacrine was the first drug approved by FDA for the treatment of Alzheimer's disease. However, its use was restricted in function of side effects observed in some patients. Investigations on the structural basis by which tacrine inhibits cholinesterases activity brought new perspectives for the desig
A review on cholinesterase inhibitors for Alzheimer's disease.
Anand P, Singh B.SourceDepartment of Chemistry, Punjabi University, Patiala, 147002, India.
Archives of pharmacal research.Arch Pharm Res.2013 Feb 24. [Epub ahead of print]
Alzheimer's disease (AD), a progressive neurodegenerative disorder, is characterized by the deficits in the cholinergic system and deposition of beta amyloid (Aβ) in the form of neurofibrillary tangles and amyloid plaques. Since the cholinergic system plays an important role in the regulation of le
Cholinergic involvement in the improving effects of Yoku-kan-san-ka-chimpi-hange (Yi-Gan-San-Jia-Chen-Pi-Ban-Xia) on the disruption of spatial cognition and the electroconvulsive shock-induced immobilization
Tetrahydroaminoacridine, a cholinesterase inhibitor, and D-cycloserine, a partial NMDA receptor-associated glycine site agonist, enhances acquisition of spatial navigation
… In this study, the kinetics of the inhibitory action of E2020 on AChE was examined in comparison with its derivatives (2A1050 and 2A1034) and the reference compound tetrahydroaminoacridine (THA) all of which have a similar action. …
Tetrahydroaminoacridine information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Tetrahydroaminoacridine Description of Tetrahydroaminoacridine ...
Tetrahydroaminoacridine - Health Forums ... A cholinesterase inhibitor that is used in the treatment of patients with Alzheimer's disease. Tetrahydroaminoacridine works by blocking an enzyme responsible for destroying a ...