English Journal

Mycoepoxydiene induces apoptosis and inhibits TPA-induced invasion in human cholangiocarcinoma cells via blocking NF-κB pathway.

Li W1, Li M2, Su X3, Qin L2, Miao M2, Yu C2, Shen Y4, Luo Q5, Chen Q6.
Biochimie.Biochimie.2014 Jun;101:183-91. doi: 10.1016/j.biochi.2014.01.012. Epub 2014 Jan 29.
Human cholangiocarcinoma (CCA) is a chemoresistant bile duct carcinoma with a poor prognosis. Conventional chemotherapy and radiotherapy have not been reported to be effective in improving long-term survival. Mycoepoxydiene (MED), a polyketide isolated from the marine fungal strain Diaporthe sp. HLY
PMID 24486723

Suppression of allergic and inflammatory responses by essential oils derived from herbal plants and citrus fruits.

Mitoshi M1, Kuriyama I1, Nakayama H2, Miyazato H2, Sugimoto K2, Kobayashi Y3, Jippo T3, Kuramochi K4, Yoshida H1, Mizushina Y1.
International journal of molecular medicine.Int J Mol Med.2014 Jun;33(6):1643-51. doi: 10.3892/ijmm.2014.1720. Epub 2014 Mar 31.
The aim of the present study was to investigate the biological activity of 20 essential oils (EOs) derived from herbal plants and citrus fruits. The in vitro anti-allergic and anti-inflammatory activities of these oils were investigated, and the EO which was found to have the strongest activity of
PMID 24682420

The effects of dissociated glucocorticoids RU24858 and RU24782 on TPA-induced skin tumor promotion biomarkers in SENCAR mice.

Kowalczyk P1, Junco JJ, Kowalczyk MC, Sosnowska R, Tolstykh O, Walaszek Z, Hanausek M, Slaga TJ.
Molecular carcinogenesis.Mol Carcinog.2014 Jun;53(6):488-97. doi: 10.1002/mc.22002. Epub 2013 Jul 12.
Glucocorticoids (GCs) are very effective at preventing carcinogen- and tumor promoter-induced skin inflammation, hyperplasia, and mouse skin tumor formation. The effects of GCs are mediated by a well-known transcription factor, the glucocorticoid receptor (GR). GR acts via two different mechanisms:
PMID 23852815

Japanese Journal

Synthesis and structure–activity studies of simplified analogues of aplysiatoxin with antiproliferative activity like bryostatin-1

Irie Kazuhiro,Kikumori Masayuki,Kamachi Hiroaki,Tanaka Keisuke,Murakami Akira,Yanagita Ryo C.,Tokuda Harukuni,Suzuki Nobutaka,Nagai Hiroshi,Suenaga Kiyotake,Nakagawa Yu
Pure and Applied Chemistry 84(6), 1341-1351, 2012-00-00
… Moreover, it showed little tumor-promoting activity and even suppressed the tumor promotion by 12-O-tetradecanoylphorbol 13-acetate (TPA) in vivo and in vitro. …
NAID 120004247252

Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7,12-dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate

OKUDAIRA Noriyuki,GOTO Motohito,YANOBU TAKANASHI Rieko,TAMURA Masato,AN Akihiro,ABE Yukiko,KANO Shigeyuki,HAGIWARA Shotaro,ISHIZAKA Yukihito,OKAMURA Tadashi
Cancer science 102(11), 2000-2006, 2011-11-10
NAID 10030244955

No Involvement of Lysophosphatidic Acid Receptor-3 in Cell Migration of Mouse Lung Tumor Cells Stimulated by 12-O-Tetradecanoylphorbol-13-acetate

Okumura Mai,Kato Kohei,Fukui Rie [他],FUKUSHIMA Nobuyuki,TSUJIUCHI Toshifumi
Journal of toxicologic pathology 24(3), 183-186, 2011-09-01
… The tumor promoting agent 12-O-tetradecanoylphorbol-13-acetate (TPA) stimulates cell migration of several tumor cells. …
NAID 10030980454