WordNet

the process of obtaining something from a mixture or compound by chemical or physical or mechanical means
the action of taking out something (especially using effort or force); "the dentist gave her a local anesthetic prior to the extraction"
the male reproductive cell; the male gamete; "a sperm is mostly a nucleus surrounded by little other cellular material" (同)sperm_cell, spermatozoon, spermatozoan
of or involving the testes; "testicular cancer"

PrepTutorEJDIC

〈U〉〈C〉引き出すこと,抜き取ること,摘出 / 〈C〉引き出されたもの,抜き取られたもの,抽出物,エキス;抜粋 / 〈U〉生まれ,皿統
〈C〉精子 / 〈U〉精液

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/12 19:21:34」(JST)

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Testicular sperm extraction (TESE) is the process of removing a small portion of tissue from the testicle under local anesthesia and extracting the few viable sperm cells present in that tissue for intracytoplasmic sperm injection (ICSI).^[1] The testicular sperm extraction process is recommended to men who cannot produce sperm by ejaculation due to azoospermia, such as that caused by primary testicular failure, congenital absence of the vas deferens or non-reconstructed vasectomy.

Intracytoplasmic sperm injection (ICSI) and testicular sperm extraction (TESE) have reduced the need for donor sperm.

Serum inhibin-B weakly indicates presence of sperm cells in the testes, raising chances for successfully achieving pregnancy through TESE, although the association is not very substantial, having a sensitivity of 0.65 (95% confidence interval [CI]: 0.56–0.74) and a specificity of 0.83 (CI: 0.64–0.93) for prediction the presence of sperm in the testes in non-obstructive azoospermia.^[2]

Seminal plasma proteins TEX101 and ECM1 were recently proposed for the differential diagnosis of azoospermia forms and subtypes, and for prediction of TESE outcome.^[3]

References

^ D.Graham, Sam; James Francis Glenn, Thomas E. Keane (2004). Glenn's urologic surgery. Lippincott Williams & Wilkins. pp. 472–482. ISBN 978-0-7817-4082-1. Cite uses deprecated parameters (help)
^ Toulis, K. A.; Iliadou, P. K.; Venetis, C. A.; Tsametis, C.; Tarlatzis, B. C.; Papadimas, I.; Goulis, D. G. (2010). "Inhibin B and anti-Mullerian hormone as markers of persistent spermatogenesis in men with non-obstructive azoospermia: a meta-analysis of diagnostic accuracy studies". Human Reproduction Update 16 (6): 713–724. doi:10.1093/humupd/dmq024. PMID 20601364. edit
^ Drabovich, A. P.; Dimitromanolakis, A.; Saraon, P.; Soosaipillai, A.; Batruch, I.; Mullen, B.; Diamandis, E.P. (2013). "Differential Diagnosis of Azoospermia with Proteomic Biomarkers ECM1 and TEX101 Quantified in Seminal Plasma". Science Translational Medicine 5 (212): 212ra160. doi:10.1126/scitranslmed.3006260. PMID 24259048.

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1. 男性不妊症の治療 treatment of male infertility
2. 死後生殖（PAR） posthumous assisted reproduction
3. 男性不妊症の評価 evaluation of male infertility
4. 卵細胞質内精子注入法 intracytoplasmic sperm injection
5. 成人男性における細胞傷害性薬物が性腺機能に及ぼす影響 effects of cytotoxic agents on gonadal function in adult men

English Journal

Azoospermia due to Spermatogenic Failure.

Berookhim BM, Schlegel PN.Author information Department of Urology, Weill Cornell Medical College, 525 East 68th Street, New York, NY 10065, USA; Urology Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.AbstractThis article summarizes the current literature regarding azoospermia caused by spermatogenic failure. The causes and genetic contributions to spermatogenic failure are reviewed. Medical therapies including use of hormonal manipulation, whether guided by a specific abnormality or empiric, to induce spermatogenesis are discussed. The role of surgical therapy, including a discussion of varicocelectomy in men with spermatogenic failure, as well as an in-depth review of surgical sperm retrieval with testicular sperm extraction and microdissection testicular sperm extraction, is provided. Finally, future directions of treatment for men with spermatogenic failure are discussed, namely, stem cell and gene therapy.
The Urologic clinics of North America.Urol Clin North Am.2014 Feb;41(1):97-113. doi: 10.1016/j.ucl.2013.08.004. Epub 2013 Sep 13.
This article summarizes the current literature regarding azoospermia caused by spermatogenic failure. The causes and genetic contributions to spermatogenic failure are reviewed. Medical therapies including use of hormonal manipulation, whether guided by a specific abnormality or empiric, to induce s
PMID 24286770

Should repeated TESE be performed following a failed TESE in men with Klinefelter Syndrome?

Haliloglu AH, Tangal S, Gulpinar O, Onal K, Pabuccu R.Author information Department of Urology, Ufuk University School of Medicine, Ankara, Turkey.AbstractThe main goal of this study was to evaluate the success rate of repeated Testicular Sperm Extraction (TESE) in Klinefelter Syndrome (KS). Eighteen patients with the diagnosis of KS who had undergone micro TESE previously were re-evaluated between May 2007 and May 2012. Testes were measured and testicular volume was calculated by orchidometer and by scrotal ultrasonography in all patients All patients underwent repeated micro TESE. Serum follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone levels and testicular volume of the patients with and without successful sperm retrieval were compared statistically. A p value of less than 0.05 was considered statistically significant. The mean age of the patients was 30.3 years. The mean testicular volume was 2.08 and 2.1 mL for right and left testes respectively. The comparisons of serum FSH, LH, testosterone levels and testicular volume between patients with and without successful sperm retrieval did not show any significant difference. Three of the 18 patients who underwent repeated micro TESE, had successful sperm retrieval and repeated TESE failed in 15 patients. Three patients with successful sperm retrieval underwent intracytoplasmic sperm injection using retrieved testicular spermatozoa. Two embryos for each patient which were determined as healthy were transferred to the wives of the patients. Pregnancy occured in one of them and a healthy female infant was born. We conclude that consideration and hope must be given for a repeated micro TESE in patients with KS, even with a minimal chance of success.
Andrology.Andrology.2014 Jan;2(1):42-4. doi: 10.1111/j.2047-2927.2013.00157.x. Epub 2013 Nov 28.
The main goal of this study was to evaluate the success rate of repeated Testicular Sperm Extraction (TESE) in Klinefelter Syndrome (KS). Eighteen patients with the diagnosis of KS who had undergone micro TESE previously were re-evaluated between May 2007 and May 2012. Testes were measured and testi
PMID 24288254

Outcome of microdissection TESE compared with conventional TESE in non-obstructive azoospermia: a systematic review.

Deruyver Y, Vanderschueren D, Van der Aa F.Author information Department of Urology, UZ Leuven, Leuven, Belgium.AbstractRetrieval of spermatozoa is unfortunately still only successful in a subset of patients suffering from non-obstructive azoospermia (NOA) by conventional testicular sperm extraction (TESE). Microdissection TESE may have some theoretical benefits over conventional TESE, but uncertainty exists about its superiority. The objective of this systematic review was therefore to compare the efficacy and safety of microTESE with conventional TESE in men with NOA. The systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. Literature was searched for studies comparing outcome of conventional TESE with microdissection TESE. Primary outcome was sperm retrieval rate (SRR). Secondary outcomes were clinical predictors of sperm retrieval as well as complication rate. Of 62 articles, a total of seven studies were included in the final analysis. Overall SRR was significantly higher in the microTESE group in comparison with conventional TESE in five of these studies. Overall sperm retrieval ranged from 16.7 to 45% in the conventional TESE vs. 42.9 to 63% in the microTESE group. A sub-analysis of the SRR according to testicular histology was available in four of the selected articles. MicroTESE in men with Sertoli cell only syndrome and hypospermatogenesis carried a small but significant more favourable outcome according to, respectively, two and one of the studies. Correlation of serum follicle stimulating hormone and testicular volume with positive outcome was variable. Fewer complications were observed on ultrasound examination after microTESE procedure. Clinical randomized studies comparing microTESE with conventional TESE in NOA are still lacking to date. Pseudo-randomized prospective data, however, show more favourable sperm retrieval in NOA for microTESE, especially in histological patterns of patchy spermatogenesis such as Sertoli cell only syndrome. However, in patients with uniform histological patterns such as maturation arrest outcome of microTESE seems less favourable.
Andrology.Andrology.2014 Jan;2(1):20-4. doi: 10.1111/j.2047-2927.2013.00148.x. Epub 2013 Nov 6.
Retrieval of spermatozoa is unfortunately still only successful in a subset of patients suffering from non-obstructive azoospermia (NOA) by conventional testicular sperm extraction (TESE). Microdissection TESE may have some theoretical benefits over conventional TESE, but uncertainty exists about it
PMID 24193894

Japanese Journal

ムンプス精巣炎罹患後に造精機能障害を来たした7症例の臨床的検討

竹島徹平,湯村寧,岩崎晧 [他],野口和美
泌尿器科紀要 = Acta urologica Japonica 61(6), 227-233, 2015-06
… The present illness, testicular volume and semen analysis of 7 of these patients were retrospectively investigated. … In the patients not conceiving successfully, testicular sperm extraction (TESE) and assisted reproductive technique (ART) are thought to be effective ways to achieve pregnancy. …
NAID 120005621961

Testicular sperm extraction and varicocelectomy for severe male infertility (Mini-Symposium : Reconsideration of the possibility of ICSI : For further improvements of the clinical performance)

Iijima Masashi,Namiki Mikio
Journal of mammalian ova research = 日本卵子学会誌 32(1), 11-17, 2015-04
NAID 40020537003

リングY染色体と考えられた染色体異常を有する無精子症患者の1例

黒田晋之介,湯村寧,浜之上はるか,保田賢吾,山中弘行,三條博之,竹島徹平,小林将貴,加藤喜健,岩崎晧,野口和美
泌尿器科紀要 = Acta urologica Japonica 60(11), 583-586, 2014-11
… The patient gave up having a child because these results indicated that no sperm would be collected even if Testicular Sperm Extraction (TESE) were performed. …
NAID 120005521617

Related Pictures

★リンクテーブル★

リンク元	「精巣内精子採取術」「TESE」「精巣内精子採取」
拡張検索	「microdisection-testicular sperm extraction」
関連記事	「extraction」「testicular」