WordNet

relating to or occurring in a term or fixed period of time; "terminal examinations"; "terminal payments"
a contact on an electrical device (such as a battery) at which electric current enters or leaves (同)pole
station where transport vehicles load or unload passengers or goods (同)terminus, depot
electronic equipment consisting of a device providing access to a computer; has a keyboard and display
being or situated at an end; "the endmost pillar"; "terminal buds on a branch"; "a terminal station"; "the terminal syllable"
causing or ending in or approaching death; "a terminal patient"; "terminal cancer"
of or relating to or situated at the ends of a delivery route; "freight pickup is a terminal service"; "terminal charges"
construct or form a web, as if by weaving (同)net
an intricate trap that entangles or ensnares its victim (同)entanglement
a fabric (especially a fabric in the process of being woven)
membrane connecting the toes of some aquatic birds and mammals
an intricate network suggesting something that was formed by weaving or interweaving; "the trees cast a delicate web of shadows over the lawn"

PrepTutorEJDIC

『終りの』,末端の / 毎期の,定期の;学期末の / 『死に至る』, / 末端 / (電池の)端子 / (町の中心に近い)空港バス発着場;(一般に,鉄道・バスの)終点,終着駅
(クモなどが紡ぎ出す)『巣』 / (クモの巣のような)網状組織;(張りめぐらした)仕掛け / (製織中の)織物 / (アヒルなど水鳥の)水かき / (輪転機の)巻取り紙
『私たちは(が)』,われわれは(が) / 《総称的に》『人は』,われわれは / 《論説・評論などで I の代りに用いて》私たちは,吾人(ごじん)は,筆者は / 《子供・病人などに対して,you の代りに養いて》あなたは / 《君主が公式の場でI の代りに用いて》余は
week / width / weight

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/01/05 19:55:28」(JST)

wiki en

The terminal web is a filamentous structure found at the apical surface of epithelial cells that possess microvilli. It is composed primarily of actin filaments stabilized by spectrin, which also anchors the terminal web to the apical cell membrane. The presence of myosin II and tropomyosin helps to explain the contractile ability of the terminal web. When contracted, the terminal web causes a decrease in diameter of the apex of the cell, causing the microvilli, which are anchored into the terminal web through their stiff actin fibers, to spread apart. This spreading apart of the microvilli aids cells in absorption.^[1]^[2]^[3]^[4]

References

^ Hirokawa N, Tilney LG, Fujiwara K, Heuser JE (1982). "Organization of actin, myosin, and intermediate filaments in the brush border of intestinal epithelial cells.". J Cell Biol. 94 (2): 425–43. doi:10.1083/jcb.94.2.425. PMC 2112874. PMID 7202010. link
^ Keller TC 3rd, Mooseker MS (1982). "Ca++-calmodulin-dependent phosphorylation of myosin, and its role in brush border contraction in vitro.". J Cell Biol. 95 (3): 943–59. doi:10.1083/jcb.95.3.943. PMC 2112925. PMID 6897550. link
^ Keller TC 3rd, Conzelman KA, Chasan R, Mooseker MS (1985). "Role of myosin in terminal web contraction in isolated intestinal epithelial brush borders.". J Cell Biol. 100 (5): 1647–55. doi:10.1083/jcb.100.5.1647. PMC 2113869. PMID 3988804. link
^ Ross, Michael H., and Wojciech Pawlina. "Chapter 5: Epithelial Tissue." Histology: a Text and Atlas : with Correlated Cell and Molecular Biology. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins Health, 2011. 110. Print.

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UpToDate Contents

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1. 心不全におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in heart failure
2. 成人における便失禁 fecal incontinence in adults
3. 進行癌における生存期間の推定 survival estimates in advanced cancer
4. ホスピス：治療理念および適切な利用 hospice philosophy of care and appropriate utilization
5. 終末期ケア：栄養および水分補給の停止 end of life care stopping nutrition and hydration

English Journal

Structural and biochemical characterisation of the KLHL3-WNK kinase interaction important in blood pressure regulation.

Schumacher FR, Sorrell FJ, Alessi DR, Bullock AN, Kurz T.AbstractWith no lysine (K) kinase-1 (WNK1) and WNK4 regulate blood pressure by controlling the activity of ion co-transporters in the kidney. Groundbreaking work has revealed that the ubiquitylation and hence levels of WNK isoforms are controlled by a Cullin-RING E3 ubiquitin ligase complex (CRL3KLHL3) that utilises Cullin3 (CUL3) and its substrate adaptor, kelch-like protein 3 (KLHL3). Loss of function mutations in either CUL3 or KLHL3 cause the hereditary high blood pressure disease Gordon's syndrome by stabilising WNK isoforms. KLHL3 binds to a highly conserved degron motif located within the C-terminal non-catalytic domain of WNK isoforms. This interaction is essential for ubiquitylation by CRL3KLHL3 and disease-causing mutations in WNK4 and KLHL3 exert their effects on blood pressure by disrupting this interaction. In the present study we report on the crystal structure of the KLHL3 kelch domain in complex with the WNK4 degron motif. This reveals an intricate web of interactions between conserved residues on the surface of the kelch domain β-propeller and the WNK4 degron motif. Importantly, many of the disease-causing mutations inhibit binding by disrupting critical interface contacts. We also present the structure of the WNK4 degron motif in complex with the kelch-like 2 (KLHL2) protein that has also been reported to bind WNK4. This confirms that KLHL2 interacts with WNK kinases in a similar manner to KLHL3, but strikingly different to how another kelch-like protein KEAP1 binds to its substrate NRF2. This study provides further insights into how kelch-like adaptor proteins recognise their substrates and provides a structural basis for how mutations in WNK4 and KLHL3 lead to hypertension.
The Biochemical journal.Biochem J.2014 Mar 18. [Epub ahead of print]
With no lysine (K) kinase-1 (WNK1) and WNK4 regulate blood pressure by controlling the activity of ion co-transporters in the kidney. Groundbreaking work has revealed that the ubiquitylation and hence levels of WNK isoforms are controlled by a Cullin-RING E3 ubiquitin ligase complex (CRL3KLHL3) that
PMID 24641320

The crystal structure of NS5A domain 1 from genotype 1a reveals new clues to the mechanism of action for dimeric HCV inhibitors.

Lambert SM1, Langley DR, Garnett JA, Angell R, Hedgethorne K, Meanwell NA, Matthews SJ.Author information 1Department of Biological Sciences, Centre for Structural Biology, Imperial College London, South Kensington, London, SW7 2AZ, UK.AbstractNew direct acting antivirals (DAAs) such as daclatasvir (DCV; BMS-790052), which target NS5A function with picomolar potency, are showing promise in clinical trials. The exact nature of how these compounds have an inhibitory effect on HCV is unknown; however, major resistance mutations appear in the N-terminal region of NS5A that include the amphipathic helix and domain 1. The dimeric symmetry of these compounds suggests that they act on a dimer of NS5A, which is also consistent with the presence of dimers in crystals of NS5A domain 1 from genotype 1b. Genotype 1a HCV is less potently affected by these compounds and resistance mutations have a greater effect than in the 1b genotypes. We have obtained crystals of domain 1 of the important 1a NS5A homologue and intriguingly, our X-ray crystal structure reveals two new dimeric forms of this domain. Furthermore, the high solvent content (75%) makes it ideal for ligand-soaking. Daclatasvir (DCV) shows 2-fold symmetry suggesting NS5A dimers may be of physiological importance and serve as potential binding sites for DCV. These dimers also allow for new conformations of a NS5A expansive network which could explain its operation on the membranous web. Additionally, sulfates bound in the crystal structure may provide evidence for the previously proposed RNA binding groove, or explain regulation of NS5A domain 2 and 3 function and phosphorylation by domain 1.
Protein science : a publication of the Protein Society.Protein Sci.2014 Mar 18. doi: 10.1002/pro.2456. [Epub ahead of print]
New direct acting antivirals (DAAs) such as daclatasvir (DCV; BMS-790052), which target NS5A function with picomolar potency, are showing promise in clinical trials. The exact nature of how these compounds have an inhibitory effect on HCV is unknown; however, major resistance mutations appear in the
PMID 24639329

Usefulness of N-terminal pro-B-type natriuretic peptide in patients admitted to the intensive care unit: a multicenter prospective observational study.

Rhee CK, Lim SY, Koh SO, Choi WI, Lee YJ, Chon GR, Kim JH, Kim JY, Lim J, Park S, Kim HC, Lee JH, Lee JH, Park J, Koh Y, Suh GY, Kim SC1; Validation of Simplified acute physiology score3 in Korean Intensive care unit (VSKI) study group & the Korean study group on respiratory failure (KOSREF).Author information 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Seoul St, Mary's Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seoul, Seocho-Gu 137-701, South Korea. cmcksc@catholic.ac.kr.AbstractBACKGROUND: The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill patients.
BMC anesthesiology.BMC Anesthesiol.2014 Mar 10;14(1):16. doi: 10.1186/1471-2253-14-16.
BACKGROUND: The role of N-terminal pro-B-type natriuretic peptide (NT-pro-BNP) as a prognostic factor in patients admitted to the intensive care unit (ICU) is not yet fully established. We aimed to determine whether NT-pro-BNP is predictive of ICU mortality in a multicenter cohort of critically ill
PMID 24612820

Japanese Journal

内蔵Webカメラを用いたVDT作業者の姿勢モニタリング (知覚情報研究会・人間生活を支援する観測･支援･評価技術)

守屋優,戸田健,劉欣欣
電気学会研究会資料. PI = The papers of Technical Meeting on "Perception Information", IEE Japan, 2014(56-80・82-93), 13-16, 2014-09-01
NAID 40020225410

防犯性に優れた高機能インターフォンシステムの開発

森健太郎,片山英昭
日本高専学会誌 : journal of the Japan Association for College of Technology 19(3), 39-46, 2014-07-31
… フォンシステムである.本システムは4つの機能から構成されている.1つ目の機能では雲台付Webカメラによる自動人物追跡を行い,2つ目の機能ではWebカメラの映像を元に不審者の自動検知を行い,3つ目の機能では外部情報端末との音声通話を行い,4つ目の機能では情報端末からアクセスできるWebカメラからの画像をまとめた画像一覧ページの提供を行う.完成したシステムで動作確認実 …
NAID 110009838932

利用者認証ネットワークにおけるNATの検出および通信の遮断

末永光弘,田中久治,大谷誠,堀良彰,岡崎泰久,渡辺健次
情報処理学会研究報告. IOT, [インターネットと運用技術] 2014-IOT-25(6), 1-6, 2014-05-15
… タのような NAT 機能をもつ機器を経由すると,認証者と実際の利用者が違う場合がある.そこで,本研究では,Java アプレットを用いてユーザ端末の実際の IP アドレスを取得することで NAT を検出する手法を考案し,Web ブラウザを用いて認証を行うシステムに実装した.また,Java アプレットが動作しないユーザ端末に対しては,パケットの TTL 値を検証することで NAT を検出する方法を実装した.これにより,認証時に NAT …
NAID 110009772686