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a silvery soft waxy metallic element of the alkali metal group; occurs abundantly in natural compounds (especially in salt water); burns with a yellow flame and reacts violently in water; occurs in sea water and in the mineral halite (rock salt) (同)Na, atomic number 11

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ソジウム,ナトリウム(金属元素;化学記号はNa)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/04 13:04:43」(JST)

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Tazobactam is a pharmaceutical drug that inhibits the action of bacterial β-lactamases, especially those belonging to the SHV-1 and TEM groups. It is commonly used as its sodium salt, tazobactam sodium.

Tazobactam is combined with the extended spectrum β-lactam antibiotic piperacillin in the drug piperacillin/tazobactam, one of the preferred antibiotic treatments for nosocomial pneumonia caused by Pseudomonas aeruginosa.^{[medical citation needed]} Tazobactam broadens the spectrum of piperacillin by making it effective against organisms that express β-lactamase and would normally degrade piperacillin.^[1]

Tazobactam is derived from the penicillin nucleus and is a penicillinic acid sulfone.

References

^ Yang Y, Rasmussen BA, Shlaes DM (1999). "Class A beta-lactamases—enzyme-inhibitor interactions and resistance". Pharmacol Ther. 83: 141–151.

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1. β-ラクタマーゼ阻害剤、カルバペネム系、およびモノバクタム系抗菌薬の併用 combination beta lactamase inhibitors carbapenems and monobactams
2. 基質特異性拡張型β-ラクタマーゼ extended spectrum beta lactamases
3. Suspected Staphylococcus aureus skin and soft tissue infections: Evaluation and management in neonates
4. 成人における確定診断を得られていない低血圧やショックの評価および初期アプローチ evaluation of and initial approach to the adult patient with undifferentiated hypotension and shock
5. βラクタム系抗生物質の長期注入投与 prolonged infusions of beta lactam antibiotics

English Journal

Rapid recovery from acute kidney injury in a patient with metformin-associated lactic acidosis and hypothermia.

Mustafa E, Lai L, Lien YH.
The American journal of medicine.Am J Med.2012 Feb;125(2):e1-2.
PMID 22269627

Protective effect of citropin 1.1 and tazobactam-piperacillin against oxidative damage and lethality in mice models of gram-negative sepsis.

Ghiselli R, Silvestri C, Cirioni O, Kamysz W, Orlando F, Calcinari A, Kamysz E, Casteletti S, Rimini M, Tocchini M, Giacometti A, Guerrieri M.SourceGeneral Surgery and Surgery Methodology Clinic, Università Politecnica delle Marche, and Analysis Laboratory, Ospedali Riuniti Umberto I-Lancisi-Salesi, Ancona, Italy.
The Journal of surgical research.J Surg Res.2011 Dec;171(2):726-33. Epub 2010 Apr 20.
BACKGROUND: Gram-negative sepsis ranks as the leading cause of death in intensive care units, and its incidence is increasing steadily and mortality rates has not changed much over recent decades.MATERIALS AND METHODS: We investigated the efficacy of the amphibian peptide, citropin 1.1 alone and in
PMID 20605608

Japanese Journal

Liver Abscess Caused by Multidrug-resistant Pseudomonas aeruginosa Treated with Colistin; A Case Report and Review of the Literature

, , , , , , , , , ,
Internal Medicine 52(12), 1407-1412, 2013
… Empirical treatment with piperacillin/tazobactam was started, and the patient initially recovered. … However, he developed a second case of sepsis caused by piperacillin/tazobactam-resistant P. … We changed the piperacillin/tazobactam to colistin and flomoxef and continued the two antibiotics for one month. …
NAID 130003365675

日本発・世界のくすり(31)日本生まれのペニシリン系薬TAZ/PIPC ゾシン静注用2.25・ゾシン静注用4.5 一般名:注射用タゾバクタムナトリウム・ピペラシリンナトリウム

大正富山医薬品株式会社
医療 63(7), 450-452, 2009-07
NAID 40016774927

Synthesis and .BETA.-lactamase inhibitory activity of 6-((1-heteroarylthioethyl-1,2,3-triazol4-yl)methylene)-penam sulfones.

, , , , , ,
The Journal of Antibiotics 47(9), 1030-1040, 1994
… The synthesis of β-lactamase inhibitory activity of a series of sodium 6-[(1-heteroarylthioethyl-1, 2, 3-triazol-4-yl)methylene]pemcillanate 1, 1-dioxides are described. … Their activity was compared with tazobactam and sulbactam. … The in vitro activity of the Z-isomers of the phenylthiadiazole derivatives (13a and 15a) was better than sulbactam against the tested β-lactamases and comparable to tazobactam especially against TEM-2 and cephalosporinase. …
NAID 130003410096

「タゾバクタム」

Tazobactam
Systematic (IUPAC) name
	(2S,3S,5R)-3-Methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid 4,4-dioxide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	B;
Legal status	Rx only;
Routes	Intravenous
Identifiers
CAS number	89786-04-9
ATC code	J01CG02
PubChem	CID 123630
DrugBank	DB01606
ChemSpider	110216
UNII	SE10G96M8W
KEGG	D00660
ChEMBL	CHEMBL404
Chemical data
Formula	C10H12N4O5S
Mol. mass	300.289 g/mol
	SMILES O=S2(=O)[C@]([C@@H](N1C(=O)C[C@H]12)C(=O)O)(Cn3nncc3)C;
	InChI InChI=1S/C10H12N4O5S/c1-10(5-13-3-2-11-12-13)8(9(16)17)14-6(15)4-7(14)20(10,18)19/h2-3,7-8H,4-5H2,1H3,(H,16,17)/t7-,8+,10+/m1/s1 ; Key:LPQZKKCYTLCDGQ-WEDXCCLWSA-N ;
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　　[★]

英: tazobactam
化: タゾバクタムナトリウム tazobactam sodium
商: ゾシン
関: ピペラシリン-タゾバクタム、ペニシリナーゼ、セファロスポリナーゼ、オキシイミノセファロスポリナーゼ

参考

http://www.labo-tech.co.jp/iyakuhin/koukinyaku_binran/num09/nm09_06.html

[1] Yang Y, Rasmussen BA, Shlaes DM (1999). "Class A beta-lactamases—enzyme-inhibitor interactions and resistance". Pharmacol Ther. 83: 141–151.

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案内

tazobactam sodium