tachyphylaxic

English Journal

Neurogenic relaxations caused by nicotine in isolated cat middle cerebral arteries.

Ayajiki K1, Okamura T, Toda N.
The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.1994 Aug;270(2):795-801.
In cat middle cerebral arterial strips denuded of the endothelium, nicotine produced a relaxation that was abolished by treatment with hexamethonium. The relaxation was partially inhibited by treatment with NG-nitro-L-arginine (L-NNA), a nitric oxide (NO) synthase inhibitor, and oxyhemoglobin, an NO
PMID 8071871

Watanabe T1, Duncan R, Lockey RF, Krzanowski JJ Jr.
Archives internationales de pharmacodynamie et de thérapie.Arch Int Pharmacodyn Ther.1988 Sep-Oct;295:204-10.
The phenomenon of histamine tachyphylaxis in vitro previously observed in the airway smooth muscle from adult dogs was investigated in airway smooth muscle from young dogs (age 72-96 days; mean: 91 days). Tachyphylaxis was demonstrated by repetitive exposure to 10(-4) M histamine (4th contractile re
PMID 3245736

Liversidge GG1, Wilson CG, Sternson WL, Kinter LB.
Journal of applied physiology (Bethesda, Md. : 1985).J Appl Physiol (1985).1988 Jan;64(1):377-83.
The dosage form (drop or spray) and site of administration (dorsal or ventral surface of the nostril) profoundly affect the distribution and clearance of a gamma-emitting 99mTc-labeled diethylenetriamine pentaacetic acid (99mTc-DTPA) solution in dogs. The slowest nasal clearance was observed for dor
PMID 3281929

脇田広美,鈴木永雄,宮本謙一
和漢医薬学雑誌 19(6), 238-245, 2002-12-20
… Scutellariae Radix and its main constituent, baicalin, concentration-dependently contracted the isolated rat aorta, and its contractile responses were tachyphylaxic. … Wogonin, another constituent in Scutellariae Radix, conversely concentration-dependently relaxed the contraction induced by phenylephrine in the isolated rat aorta, and the relaxation was not tachyphylaxic. …
NAID 110001846577

堀井大治郎,原祐司,花塚光男,西広吉
日本薬理学雑誌 87(4), 417-426, 1986
抗アレルギー薬MY-5116およびその主要活性代謝物であるMY-1250の心臓血管系に対する作用を，麻酔イヌを中心にDSCGと比較検討した．麻酔イヌおよび無麻酔・無拘束ラットでのMY-5116300 mg/kg経口投与では，血圧，心拍数に対し影響は認められなかった．麻酔イヌでの静脈内投与でMY-1250は3 μg/kg，DSCGは10 μg/kgから，用量依存性の血圧下降ならびに徐脈作用を発現し， …
NAID 130000759674

Novel Therapies for Heart Failure