WordNet
- abnormally rapid heartbeat (over 100 beats per minute)
PrepTutorEJDIC
- 心拍急速(心臓の異常に速い拍動) 頻拍 頻脈
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English Journal
- Both α1- and α2-adrenoceptors in the Insular Cortex Are Involved in the Cardiovascular Responses to Acute Restraint Stress in Rats.
- Alves FH1, Crestani CC2, Resstel LB1, Corrêa FM1.Author information 1Department of Pharmacology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, SP, Brazil.2Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences of Araraquara, Univ. Estudual Paulista - UNESP, Araraquara, SP, Brazil.AbstractThe insular cortex (IC) is a limbic structure involved in cardiovascular responses observed during aversive threats. However, the specific neurotransmitter mediating IC control of cardiovascular adjustments to stress is yet unknown. Therefore, in the present study we investigated the role of local IC adrenoceptors in the cardiovascular responses elicited by acute restraint stress in rats. Bilateral microinjection of different doses (0.3, 5, 10 and 15 nmol/100 nl) of the selective α1-adrenoceptor antagonist WB4101 into the IC reduced both the arterial pressure and heart rate increases elicited by restraint stress. However, local IC treatment with different doses (0.3, 5, 10 and 15 nmol/100 nl) of the selective α2-adrenoceptor antagonist RX821002 reduced restraint-evoked tachycardia without affecting the pressor response. The present findings are the first direct evidence showing the involvement of IC adrenoceptors in cardiovascular adjustments observed during aversive threats. Our findings indicate that IC noradrenergic neurotransmission acting through activation of both α1- and α2-adrenoceptors has a facilitatory influence on pressor response to acute restraint stress. Moreover, IC α1-adrenoceptors also play a facilitatory role on restraint-evoked tachycardiac response.
- PloS one.PLoS One.2014 Jan 3;9(1):e83900. doi: 10.1371/journal.pone.0083900. eCollection 2014.
- The insular cortex (IC) is a limbic structure involved in cardiovascular responses observed during aversive threats. However, the specific neurotransmitter mediating IC control of cardiovascular adjustments to stress is yet unknown. Therefore, in the present study we investigated the role of local I
- PMID 24404141
- Studies on two polyherbal formulations (ZPTO and ZTO) for comparison of their antidyslipidemic, antihypertensive and endothelial modulating activities.
- Aziz N, Mehmood MH, Gilani AH.Author information Natural Product Research Division, Department of Biological and Biomedical Sciences, The Aga Khan University Medical College, Karachi 74800, Pakistan. anwarhgilani@yahoo.com.AbstractBACKGROUND: Cardiovascular disorders (CVDs) are the leading cause of disease burden worldwide. Apart from available synthetic drugs used in CVDs, there are many herbal formulations including POL-10 (containing 10 herbs), which have been shown to be effective in animal studies but POL-10 was found to cause tachycardia in rodents as its side effect. This study was designed to modify the composition of POL-10 for better efficacy and/or safety profile in CVDs.
- BMC complementary and alternative medicine.BMC Complement Altern Med.2013 Dec 26;13:371. doi: 10.1186/1472-6882-13-371.
- BACKGROUND: Cardiovascular disorders (CVDs) are the leading cause of disease burden worldwide. Apart from available synthetic drugs used in CVDs, there are many herbal formulations including POL-10 (containing 10 herbs), which have been shown to be effective in animal studies but POL-10 was found to
- PMID 24370063
- Role of the bed nucleus of the stria terminalis in cardiovascular changes following chronic treatment with cocaine and testosterone: a role beyond drug seeking in addiction?
- Cruz FC, Alves FH, Leão RM, Planeta CS, Crestani CC.Author information Laboratory of Pharmacology, Department of Natural Active Principles and Toxicology, School of Pharmaceutical Sciences, Univ. Estadual Paulista - UNESP, Araraquara, SP 14801-902, Brazil; Behavioral Neuroscience Branch, Intramural Research Program, National Institute on Drug Abuse, US National Institutes of Health, Department of Health and Human Services, Baltimore, MD, USA.AbstractNeural plasticity has been observed in the bed nucleus of the stria terminalis (BNST) following exposure to both cocaine and androgenic-anabolic steroids. Here we investigated the involvement of the BNST on changes in cardiovascular function and baroreflex activity following either single or combined administration of cocaine and testosterone for 10 consecutive days in rats. Single administration of testosterone increased values of arterial pressure, evoked rest bradycardia and reduced baroreflex-mediated bradycardia. These effects of testosterone were not affected by BNST inactivation caused by local bilateral microinjections of the nonselective synaptic blocker CoCl2. The single administration of cocaine as well as the combined treatment with testosterone and cocaine increased both bradycardiac and tachycardiac responses of the baroreflex. Cocaine-evoked baroreflex changes were totally reversed after BNST inactivation. However, BNST inhibition in animals subjected to combined treatment with cocaine and testosterone reversed only the increase in reflex tachycardia, whereas facilitation of reflex bradycardia was not affected by local BNST treatment with CoCl2. In conclusion, the present study provides the first direct evidence that the BNST play a role in cardiovascular changes associated with drug abuse. Our findings suggest that alterations in cardiovascular function following subchronic exposure to cocaine are mediated by neural plasticity in the BNST. The single treatment with cocaine and the combined administration of testosterone and cocaine had similar effects on baroreflex activity, however the association with testosterone inhibited cocaine-induced changes in the BNST control of reflex bradycardia. Testosterone-induced cardiovascular changes seem to be independent of the BNST.
- Neuroscience.Neuroscience.2013 Dec 3;253:29-39. doi: 10.1016/j.neuroscience.2013.08.034. Epub 2013 Aug 29.
- Neural plasticity has been observed in the bed nucleus of the stria terminalis (BNST) following exposure to both cocaine and androgenic-anabolic steroids. Here we investigated the involvement of the BNST on changes in cardiovascular function and baroreflex activity following either single or combine
- PMID 23994153
Japanese Journal
- Central mechanisms of cardiovascular regulation during exercise: Integrative functions of the nucleus of the solitary tract
- Waki Hidefumi
- The Journal of Physical Fitness and Sports Medicine 1(2), 253-261, 2012
- … The signals to the RVLM activate sympathetic premotor neurons that, in turn, induce pressor and tachycardiac responses. …
- NAID 130001930865
- Bepridil induced ventricular fibrillation in a patient with tachycardia induced cardiomyopathy due to tachycardiac atrial fibrillation
- 飛梅 威,松本 万夫,エブル ゴルクック・スクリエ,上西 正洋,石田 仁志,堀田 ゆりか,原 幹,加藤 律史,西村 重敬,小宮山 伸之
- Shinzo 43(SUPPL.2), S2_58-S2_64, 2011
- NAID 130002585111
- 症例 下肢切断術の術中・術後の心房細動に使用した塩酸ランジオロールの薬物動態シミュレーション
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- forum Join the Word of the Day Mailing List For webmasters TheFreeDictionary Google Bing? Word / Article Starts with Ends with Text ... tach·y·car·di·ac (t k-kär d-k) adj. Of, relating to, or affected by tachycardia. tachycardiac [-kär ...
★リンクテーブル★
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- 英
- tachycardiac
- 関
- 頻脈性
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- 英
- tachycardiac
- 関
- 頻拍性
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- 関
- tachyarrhythmia
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