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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/12/03 12:42:11」(JST)

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Tacalcitol (1,24-dihydroxyvitamin D₃) is a synthetic vitamin D₃ analog.^[1]

Tacalcitol is marketed under several names, including Curatoderm and Bonalfa.

Mechanism

Tacalcitol reduces excessive cell turnover in the epidermis by interacting with vitamin D receptors on keratinocytes.

Uses

It is usually prescribed by a general practitioner or dermatologist for the treatment of psoriasis, chronic chapped lips and other severe dry skin conditions because of its ability to reduce excessive skin cell turnover. It is available as an ointment or lotion.

It has also been used for vitiligo^[2] and Hailey-Hailey disease.^[3]

References

^ Fukuoka M, Sakurai K, Ohta T, Kiyoki M, Katayama I (2001). "Tacalcitol, an active vitamin D3, induces nerve growth factor production in human epidermal keratinocytes". Skin Pharmacol. Appl. Skin Physiol. 14 (4): 226–33. doi:10.1159/000056351. PMID 11464105.
^ Leone G, Pacifico A, Iacovelli P, Paro Vidolin A, Picardo M (March 2006). "Tacalcitol and narrow-band phototherapy in patients with vitiligo". Clin. Exp. Dermatol. 31 (2): 200–5. doi:10.1111/j.1365-2230.2005.02037.x. PMID 16487090.
^ Aoki T, Hashimoto H, Koseki S, Hozumi Y, Kondo S (November 1998). "1alpha,24-dihydroxyvitamin D3 (tacalcitol) is effective against Hailey-Hailey disease both in vivo and in vitro". Br. J. Dermatol. 139 (5): 897–901. doi:10.1046/j.1365-2133.1998.02522.x. PMID 9892963.

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1. 乾癬の治療 treatment of psoriasis
2. 尋常性白斑 vitiligo
3. 角層下膿疱性皮膚症 subcorneal pustular dermatosis
4. Targeted phototherapy
5. 結節性痒疹 prurigo nodularis

English Journal

Tacalcitol: A useful adjunct to narrow band ultraviolet B phototherapy in psoriasis.

Aggarwal P1, Aggarwal K1, Jain VK1.
The Journal of dermatological treatment.J Dermatolog Treat.2016 Apr 7:1-6. [Epub ahead of print]
BACKGROUND: A combination of calcipotriol and narrow-band ultraviolet B (NBUVB) has been shown to have a superior efficacy as compared to NBUVB alone in psoriasis. Very few studies have been performed using the combination of NBUVB with tacalcitol, a comparatively newer Vitamin D analogue.OBJECTIVE:
PMID 27052200

Motor neuron-like NSC-34 cells as a new model for the study of vitamin D metabolism in the brain.

Almokhtar M1, Wikvall K1, Ubhayasekera SJ2, Bergquist J2, Norlin M3.
The Journal of steroid biochemistry and molecular biology.J Steroid Biochem Mol Biol.2016 Apr;158:178-88. doi: 10.1016/j.jsbmb.2015.12.010. Epub 2015 Dec 15.
Vitamin D3 is a pro-hormone, which is sequentially activated by 25- and 1α-hydroxylation to form 25-hydroxyvitamin D3 [25(OH)D3] and 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], respectively. Subsequent inactivation is performed by 24-hydroxylation. These reactions are carried out by a series of CYP
PMID 26704532

Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis.

Wang LF1, Tai CF2, Chien CY2, Chiang FY3, Chen JY4.
The Kaohsiung journal of medical sciences.Kaohsiung J Med Sci.2015 May;31(5):235-40. doi: 10.1016/j.kjms.2015.02.001. Epub 2015 Mar 6.
Vitamin D and its derivatives have modulatory effects in immunological and inflammatory responses. Such properties suggest that they might have an impact on chronic inflammatory airway diseases, including nasal polyposis. The aim of this study was to understand the role of vitamin D in chronic rhino
PMID 25910558

Japanese Journal

尋常性白斑に対する活性型ビタミン D3 外用と紫外線照射併用療法の有効性についての検討:―活性型ビタミン D3 外用に日光浴もしくはナローバンド UVB 照射を併用した患者群の比較―

種村篤,高橋彩,上木裕理子,山中隆嗣,室田浩之,山口裕史,片山一朗
皮膚の科学 10(6), 485-493, 2011
尋常性白斑に対する治療法の1つとして近年活性型ビタミン D3 外用剤の白斑に対する有効性が報告される1~7)。今回の研究では，活性型ビタミン D3 外用を基本的な治療とし，紫外線療法の中で日常生活での日光浴を励行する群（A群）と近年の紫外線療法の中で最も頻用されているナローバンド UVB を併用療法として用いる群（B群）での治療効果を比較した。結果，平均面積変化率はA群で29％であったのに対しB群 …
NAID 130004546879

Successful treatment of disseminated superficial actinic porokeratosis with tacalcitol lotion

ABE Masatoshi,YOKOYAMA Yoko,ISHIKAWA Osamu
Journal of dermatology 37(10), 913-915, 2010-10-01
NAID 10027572447

活性型ビタミンD誘導体の創薬研究と実用的合成法

久保寺登
有機合成化学協会誌 68(9), 904-910, 2010-09-01
… Six active vitamin D derivatives (maxacalcitol, calcipotriol, tacalcitol, paricalcitol, doxercalciferol, and falecalcitriol) based on the findings during the third milestone are now commercially available and contributing to current clinical practice. …
NAID 10026870556

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Tacalcitol
Clinical data
Synonyms	(1α,24R)-1,24-Dihydroxyvitamin D3
AHFS/Drugs.com	International Drug Names
Routes of; administration	Topical
ATC code	D05AX04 (WHO);
Identifiers
	IUPAC name (1S,3R,5Z,7E,24R)-9,10-secocholesta-5,7,10-triene-1,3,24-triol;
CAS Number	57333-96-7 ;
PubChem CID	5283734;
IUPHAR/BPS	2780;
ChemSpider	4446823 ;
UNII	C2W72OJ5ZU;
ChEMBL	CHEMBL340361 ;
ECHA InfoCard	100.220.855
Chemical and physical data
Formula	C27H44O3
Molar mass	416.64
3D model (JSmol)	Interactive image;
	SMILES O[C@@H]1CC(\C(=C)[C@@H](O)C1)=C\C=C2/CCC[C@]3([C@H]2CC[C@@H]3[C@H](C)CC[C@@H](O)C(C)C)C ;
	InChI InChI=1S/C27H44O3/c1-17(2)25(29)13-8-18(3)23-11-12-24-20(7-6-14-27(23,24)5)9-10-21-15-22(28)16-26(30)19(21)4/h9-10,17-18,22-26,28-30H,4,6-8,11-16H2,1-3,5H3/b20-9+,21-10-/t18-,22-,23-,24+,25-,26+,27-/m1/s1 ; Key:BJYLYJCXYAMOFT-RSFVBTMBSA-N ;
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英: tacalcitol
商: ボンアルファ、アルファタカシル、ボンアルファハイ
関: 活性型ビタミンD3、その他の外皮用薬

[pmid11464105-1] Fukuoka M, Sakurai K, Ohta T, Kiyoki M, Katayama I (2001). "Tacalcitol, an active vitamin D3, induces nerve growth factor production in human epidermal keratinocytes". Skin Pharmacol. Appl. Skin Physiol. 14 (4): 226–33. doi:10.1159/000056351. PMID 11464105.

[pmid16487090-2] Leone G, Pacifico A, Iacovelli P, Paro Vidolin A, Picardo M (March 2006). "Tacalcitol and narrow-band phototherapy in patients with vitiligo". Clin. Exp. Dermatol. 31 (2): 200–5. doi:10.1111/j.1365-2230.2005.02037.x. PMID 16487090.

[pmid9892963-3] Aoki T, Hashimoto H, Koseki S, Hozumi Y, Kondo S (November 1998). "1alpha,24-dihydroxyvitamin D3 (tacalcitol) is effective against Hailey-Hailey disease both in vivo and in vitro". Br. J. Dermatol. 139 (5): 897–901. doi:10.1046/j.1365-2133.1998.02522.x. PMID 9892963.

v t e Vitamin D receptor modulators
VDR	Agonists: 7-Dehydrocholesterol 22-Oxacalcitriol 25-Hydroxyergocalciferol Alfacalcidol Calcifediol Calciferol Calcipotriol Calcitriol Cholecalciferol (vitamin D₃) Dihydrotachysterol Doxercalciferol EB-1089 Eldecalcitol Ercalcidiol Ercalcitriol Ergocalciferol (vitamin D₂) Lithocholic acid Paricalcitol Tacalcitol
See also Receptor/signaling modulators Nuclear receptor modulators

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