Differentiation of Spiral Ganglion-Derived Neural Stem Cells into Functional Synaptogenetic Neurons.
Li X1, Aleardi A2, Wang J1, Zhou Y1, Andrade R2, Hu Z1.
Stem cells and development.Stem Cells Dev.2016 May 15;25(10):803-13. doi: 10.1089/scd.2015.0345. Epub 2016 May 2.
Spiral ganglion neurons (SGNs) are usually damaged in sensorineural hearing loss. SGN-derived neural stem cells (NSCs) have been identified and proposed to differentiate into neurons to replace damaged SGNs. However, it remains obscure whether SGN-NSC-derived neurons (ScNs) are electrophysiologicall
Acetylcholinesterase and agrin: different functions, similar expression patterns, multiple roles.
Mis K1, Matkovic U, Pirkmajer S, Sciancalepore M, Lorenzon P, Mars T, Grubic Z.
Chemico-biological interactions.Chem Biol Interact.2013 Mar 25;203(1):297-301. doi: 10.1016/j.cbi.2012.10.009. Epub 2012 Oct 29.
Acetylcholinesterase (AChE) and agrin play unique functional roles in the neuromuscular junction (NMJ). AChE is a cholinergic and agrin a synaptogenetic component. In spite of their different functions, they share several common features: their targeting is determined by alternative splicing; unlike
Destruction of the nigrostriatal dopaminergic pathway by the administration of 6-OHDA generates an animal model of Parkinson's disease. The main characteristic of this progressive neurological disorder is the loss of the dopaminergic neurons located in the substantia nigra pars compacta (SNc). Dopam
Localization of Brain-Derived Neurotrophic Factor and Neurotrophin-3RNA Transcripts in the Brain of Reeler, Weaver and pcd Mutant Mice
Lazaros C.TRIARHOU,Nati ROCAMORA,Jose M.PALACIOS,
Acta medica et biologica 46(3), 93-99, 1998-09
… Previous developmental studies in rat cerebellum point to a possible involvement of NT-3 in early migratory and synaptogenetic events and of BDNF as a maintenance factor at later stages. …