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1. 小児における片頭痛の病態生理、臨床的特徴、および診断 pathophysiology clinical features and diagnosis of migraine in children
2. 腰椎穿刺：小児における適応、禁忌、手技、および合併症 lumbar puncture indications contraindications technique and complications in children
3. 成人における緊張型頭痛：予防的治療 tension type headache in adults preventive treatment
4. 薬物乱用頭痛：病因、臨床的特徴、および診断 medication overuse headache etiology clinical features and diagnosis
5. ミオクローヌスの分類および評価 classification and evaluation of myoclonus

English Journal

Enhanced GABAergic synaptic transmission at VLPAG neurons and potent modulation by oxycodone in a bone cancer pain model.

Takasu K1, Ogawa K, Nakamura A, Kanbara T, Ono H, Tomii T, Morioka Y, Hasegawa M, Shibasaki M, Mori T, Suzuki T, Sakaguchi G.
British journal of pharmacology.Br J Pharmacol.2015 Apr;172(8):2148-64. doi: 10.1111/bph.13039. Epub 2015 Feb 10.
BACKGROUND AND PURPOSE: We demonstrated previously that oxycodone has potent antinociceptive effects at supraspinal sites. In this study, we investigated changes in neuronal function and antinociceptive mechanisms of oxycodone at ventrolateral periaqueductal gray (VLPAG) neurons, which are a major s
PMID 25521524

The activation of supraspinal GPR40/FFA1 receptor signalling regulates the descending pain control system.

Nakamoto K1, Nishinaka T, Sato N, Aizawa F, Yamashita T, Mankura M, Koyama Y, Kasuya F, Tokuyama S.
British journal of pharmacology.Br J Pharmacol.2015 Mar;172(5):1250-62. doi: 10.1111/bph.13003. Epub 2015 Jan 12.
BACKGROUND AND PURPOSE: The ω-3 polyunsaturated fatty acids exert antinociceptive effects in inflammatory and neuropathic pain; however, the underlying mechanisms remain unclear. Docosahexaenoic acid-induced antinociception may be mediated by the orphan GPR40, now identified as the free fatty acid
PMID 25362997

Antinociceptive effect of intracerebroventricular administration of glycine transporter-2 inhibitor ALX1393 in rat models of inflammatory and neuropathic pain.

Takahashi Y1, Hara K2, Haranishi Y1, Terada T1, Obara G1, Sata T1.
Pharmacology, biochemistry, and behavior.Pharmacol Biochem Behav.2015 Mar;130:46-52. doi: 10.1016/j.pbb.2015.01.001. Epub 2015 Jan 9.
Glycinergic transmission has an important role in regulating nociception in the spinal cord. The glycine transporter-2 (GlyT2) is localized at presynaptic terminals of glycinergic neurons and eliminates glycine from the synaptic cleft to terminate glycinergic transmission. Systemic and intrathecal a
PMID 25579325

Kishioka Shiroh,Kiguchi Norikazu,Kobayashi Yuka,Saika Fumihiro
Journal of Pharmacological Sciences 125(2), 117-124, 2014
… Systemic administration of NIC elicits the release of endogenous opioids (endorphins, enkephalins, and dynorphins) in the supraspinal cord. … The endogenous opioid system participates in NIC-induced antinociception, but not HPA axis activation. … Moreover, NIC-induced antinociception is mediated by α4β2 and α7 nAChRs, while NIC-induced HPA axis activation is mediated by α4β2, not α7, suggesting that the effects of NIC on the endogenous opioid system are mediated by α7, not α4β2. …
NAID 130004438636

西中崇,松本健吾,中本賀寿夫 [他],安保明博,万倉三正,小山豊,徳山尚吾
YAKUGAKU ZASSHI 133(5), 493-499, 2013
… Here, we performed elucidation of mechanisms underlying DHA-induced antinociception. … Furthermore, the pretreatment of anti β-endorphin antiserum inhibited DHA-induced antinociception. … These findings suggest that DHA-induced antinociception via β-endorphin release may be mediated through GPR40 signaling in the supraspinal area. …
NAID 130003361941

<Originals>Gabapentin produces antinociceptive effects on the spinal cord with simultaneous activation of descending facilitation in spinal nerve-ligated rats

Yabuta Koichi,Takasugi Yoshihiro,Tabuchi Masaki,Mizuguchi Nobuyuki,Koga Yoshihisa,Higashino Hideaki,Nakao Shinichi
Acta Medica Kinki University 36(1), 7-14, 2011-06
… Although both spinal and supraspinal neuronal mechanisms participate in the antinociceptive effects of gabapentin, the supraspinal contribution to the effects of gabapentin at the spinal level remains unclear. … The results of this study indicate that gabapentin causes both apparent antinociception at the spinal level and simultaneousdescending facilitation in neuropathic pain conditions. …
NAID 120003291651