Proteins.Proteins.2015 Oct;83(10):1849-58. doi: 10.1002/prot.24869. Epub 2015 Aug 24.
CTDK-I is a yeast kinase complex that phosphorylates the C-terminal repeat domain (CTD) of RNA polymerase II (Pol II) to promote transcription elongation. CTDK-I contains the cyclin-dependent kinase Ctk1 (homologous to human CDK9/CDK12), the cyclin Ctk2 (human cyclin K), and the yeast-specific subun
Residual Conformational Entropies on the Sugar-Phosphate Backbone of Nucleic Acids: An Analysis of the Nucleosome Core DNA and the Ribosome.
Mak CH1, Sani LL1, Villa AN1.
The journal of physical chemistry. B.J Phys Chem B.2015 Aug 20;119(33):10434-47. doi: 10.1021/acs.jpcb.5b04839. Epub 2015 Aug 6.
A nucleic acid folds according to its free energy, but persistent residual conformational fluctuations remain along its sugar-phosphate backbone even after secondary and tertiary structures have been assembled, and these residual conformational entropies provide a rigorous lower bound for the foldin
Structure and Mechanism of Dimer-Monomer Transition of a Plant Poly(A)-Binding Protein upon RNA Interaction: Insights into Its Poly(A) Tail Assembly.
Domingues MN1, Sforça ML1, Soprano AS1, Lee J2, de Souza Tde A3, Cassago A4, Portugal RV4, de Mattos Zeri AC1, Murakami MT1, Sadanandom A2, de Oliveira PS1, Benedetti CE5.
Journal of molecular biology.J Mol Biol.2015 Jul 31;427(15):2491-506. doi: 10.1016/j.jmb.2015.05.017. Epub 2015 May 24.
Poly(A)-binding proteins (PABPs) play crucial roles in mRNA biogenesis, stability, transport and translational control in most eukaryotic cells. Although animal PABPs are well-studied proteins, the biological role, three-dimensional structure and RNA-binding mode of plant PABPs remain largely unchar
The latest Tweets from Shane Caldwell (@superhelical). Biochemist. Structural Biologist. Eukaryote. Seattle, WA ... consider: a protocols journal written like a recipe blog just like 1000 words about how nice the weather has been ...
The cap-helix domain forms a 42-turn [alpha] helix that exhibits a superhelical structure with a quarter turn, and the cap-ring domain at the end of the cap forms a U-shaped structure with helical elements at both ends (Fig.