関: amisulpride、sultopride hydrochloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/08/20 14:13:48」(JST)

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Sultopride (Barnetil, Barnotil, Topral) is an atypical antipsychotic of the benzamide chemical class used in Europe, Japan, and Hong Kong for the treatment of schizophrenia.^[1]^[2]^[3] It was launched by Sanofi-Aventis in 1976.^[1] Sultopride acts as a selective D₂ and D₃ receptor antagonist.^[4] It has also been shown to have clinically-relevant affinity for the GHB receptor as well, a property it shares in common with amisulpride and sulpiride.^[5]

References

^ ^a ^b José Miguel Vela; Helmut Buschmann; Jörg Holenz; Antonio Párraga; Antoni Torrens (2007). Antidepressants, Antipsychotics, Anxiolytics: From Chemistry and Pharmacology to Clinical Application. Weinheim: Wiley-VCH. ISBN 3-527-31058-4. http://books.google.com/books?id=yXD4QA-Y_Z0C&lpg=PA537.
^ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0. http://books.google.com/?id=5GpcTQD_L2oC&lpg=PA1624&dq=sultopride&pg=PA983.
^ European Drug Index, 4th Edition. Boca Raton: CRC Press. 1998. ISBN 3-7692-2114-1. http://books.google.com/books?id=HiSdvzs2pPAC&lpg=PA136.
^ Burstein, E. S.; Ma, J; Wong, S; Gao, Y; Pham, E; Knapp, AE; Nash, NR; Olsson, R et al. (2005). "Intrinsic efficacy of antipsychotics at human D2, D3, and D4 dopamine receptors: identification of the clozapine metabolite N-desmethylclozapine as a D2/D3 partial agonist". The Journal of Pharmacology and Experimental Therapeutics 315 (3): 1278–87. doi:10.1124/jpet.105.092155. PMID 16135699.
^ Maitre M, Ratomponirina C, Gobaille S, Hodé Y, Hechler V (1994). "Displacement of [3H] gamma-hydroxybutyrate binding by benzamide neuroleptics and prochlorperazine but not by other antipsychotics". Eur J Pharmacol. 256 (2): 211–4. doi:10.1016/0014-2999(94)90248-8. PMID 7914168.

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English Journal

[The role of zolpidem in improving catatonic schizophrenia. Case report].

Hlal H1, Kettani N2, Berhili N2, Rammouz I2, Aalouane R2.
Presse médicale (Paris, France : 1983).Presse Med.2014 Sep;43(9):1018-20. doi: 10.1016/j.lpm.2013.11.023. Epub 2014 Apr 13.
PMID 24726030

Current status of atypical antipsychotics for the treatment of fibromyalgia.

Rico-Villademoros F1, Calandre EP2, Slim M2.
Drugs of today (Barcelona, Spain : 1998).Drugs Today (Barc).2014 Jun;50(6):435-44. doi: 10.1358/dot.2014.50.6.2127023.
The treatment of fibromyalgia requires pharmacological and nonpharmacological therapies. The pharmacological treatment of fibromyalgia is limited to a few drugs that have been demonstrated to be moderately effective in some but not all dimensions of the disease. Therefore, the search for new drugs t
PMID 24983591

Amisulpride treatment of somatoform disorders: not just chronic fatigue.

Goswami K1, Saddichha S, Chaturvedi SK.
American journal of therapeutics.Am J Ther.2014 Mar-Apr;21(2):e48-9. doi: 10.1097/MJT.0b013e3182383c78.
Amisulpride has been used to treat psychotic disorders and more recently even chronic fatigue. We describe 2 cases with somatoform disorders and who responded to low-dose amisulpride.
PMID 23011165

Japanese Journal

Selective determination of sultopride in human plasma using high-performance liquid chromatography with ultraviolet detection and particle beam mass spectrometry

JITSUFUCHI Narumi,KUDO Keiko,TOKUNAGA Hironori,IMAMURA Tohru
Journal of chromatography. B, Biomedical sciences and applications 690(1), 153-159, 1997-03-07
NAID 10024512176

Sensitive and selective determination of sultopride in human plasma using high-performance liquid chromatography with ultraviolet detection and particle beam mass spectrometry

JITSUFUCHI N.
J Chromatogr B 690, 153-159, 1997
NAID 80009575803

Differences in Effects of Sultopride and Sulpiride on Dopamine Turnover in Rat Brain

MORIUCHI Kazunari
Neurochem. Res. 20(1), 95-99, 1995
NAID 30012321722

Related Pictures

★リンクテーブル★

リンク元	「スルトプリド」「amisulpride」
拡張検索	「sultopride hydrochloride」

「スルトプリド」

Sultopride
Systematic (IUPAC) name
	N-[(1-ethylpyrrolidin-2-yl)methyl]-5-ethylsulfonyl-2-methoxy-benzamide
Clinical data
AHFS/Drugs.com	International Drug Names
Pregnancy cat.	?
Legal status	℞ Prescription only
Routes	Oral, IM
Pharmacokinetic data
Half-life	3–5 hours
Identifiers
CAS number	53583-79-2
ATC code	N05AL02
PubChem	CID 5357
ChemSpider	5164
UNII	AA0G3TW31W
KEGG	D08549
ChEMBL	CHEMBL277945
Chemical data
Formula	C17H26N2O4S
Mol. mass	354.46 g/mol
	SMILES O=S(=O)(c1cc(c(OC)cc1)C(=O)NCC2N(CC)CCC2)CC;
	InChI InChI=1S/C17H26N2O4S/c1-4-19-10-6-7-13(19)12-18-17(20)15-11-14(24(21,22)5-2)8-9-16(15)23-3/h8-9,11,13H,4-7,10,12H2,1-3H3,(H,18,20) ; Key:UNRHXEPDKXPRTM-UHFFFAOYSA-N ;
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